Results 61 to 70 of about 8,950,905 (317)

Increased tumor-associated mast cells facilitate thyroid cancer progression by inhibiting CD8+ T cell function through galectin-9

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2023
As an important component of solid tumors, mast cells show specific phenotypes in various tumor microenvironments. However, the precise mechanism of mast cell accumulation and the phenotypic features of thyroid cancer (TC) remain largely unknown.
Yanli Hou, Qiang Wang, Liuliu Su, Ying Zhu, Yun Xiao, Fei Feng   +5 more
semanticscholar   +1 more source

Therapeutic potential of Galectin‐9 in human disease

Medicinal Research Reviews, 2011
In recent years, an important role has emerged for the glycan‐binding protein Galectin‐9 (Gal‐9) in health and disease. In normal physiology, Gal‐9 seems to be a pivotal modulator of T‐cell immunity by inducing apoptosis in specific T‐cell subpopulations. Because these T‐cell populations are associated with autoimmunity, inflammatory disease, and graft
Wiersma, Valerie R., de Bruyn, Marco, Helfrich, Wijnand, Bremer, Edwin   +3 more
openaire   +3 more sources

Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death

Journal of Biological Chemistry, 2022
Antibodies that target immune checkpoint proteins such as programmed cell death protein 1, programmed death ligand 1, and cytotoxic T-lymphocyte-associated antigen 4 in human cancers have achieved impressive clinical success; however, a significant proportion of patients fail to respond to these treatments.
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Weiya Xia, Boning Liu, Yu-Yi Chu, Laura Bover, Long Vien, Mien-Chie Hung   +9 more
openaire   +2 more sources

Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements

Biomolecules, 2021
Galectins are one of the critical players in the tumor microenvironment–tumor crosstalk and the regulation of local immunity. Galectin-9 has been in the limelight in tumor immunology.
Matyas Meggyes, David U Nagy, Timea Balassa, Krisztina Godony, Agnes Peterfalvi, Laszlo Szereday, Beata Polgar   +6 more
doaj   +1 more source

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair [PDF]

, 2011
Members of the galectin family of endogenous lectins are potent adhesion/growth-regulatory effectors. Their multi-functionality opens possibilities for their use in bioapplications. We studied whether human galectins induce the conversion of human dermal
Lacina, Lukas, André, Sabine, Kaltner, Herbert, Karel Smetana, Jr., Gabius, Hans-Joachim, Peter Gal, Szabo, Pavol, Eva Sykova, Gal, Peter, Zima, Tomas, Sabine André, Tomas Zima, Smetana, Karel, Pavol Szabo, Barbora Dvořánková, Dvorankova, Barbora, Hans-Joachim Gabius, Jana Uhrova, Sykova, Eva, Lukas Lacina, Uhrova, Jana, Herbert Kaltner   +21 more
core   +1 more source

Role of galectin-9 in the development of gestational diabetes mellitus. [PDF]

Sci Rep
Galectin-9 (Gal-9) is highly expressed in trophoblasts in placenta. Interaction between Gal-9 and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) is important for the differentiation of tissue resident natural killer (trNK) cells in placenta and maintenance of normal pregnancy.
Albuayjan HHH, Watanabe M, Sugawara R, Katsuyama E, Mise K, Oi Y, Kanno A, Yang B, Tahara T, Nojima I, Nakatsuka A, Eguchi J, Maki J, Eto E, Hayata K, Masuyama H, Wada J.   +16 more
europepmc   +4 more sources

Carbohydrate-recognition domains of galectin-9 are involved in intermolecular interaction with galectin-9 itself and other members of the galectin family [PDF]

Glycobiology, 2007
Galectin-9 (Gal-9) is a tandem-repeat-type member of the galectin family associated with diverse biological processes, such as apoptosis, cell aggregation, and eosinophil chemoattraction. Although the detailed sugar-binding specificity of Gal-9 has been elucidated, molecular mechanisms that underlie these functions remain to be investigated. During the
Nobumitsu, Miyanishi, Nozomu, Nishi, Hiroko, Abe, Yumiko, Kashio, Rika, Shinonaga, Shin-ichi, Nakakita, Wataru, Sumiyoshi, Akira, Yamauchi, Takanori, Nakamura, Mitsuomi, Hirashima, Jun, Hirabayashi   +10 more
openaire   +2 more sources

A novel monoclonal antibody for detection of galectin-9 in tissue sections: application to human tissues infected by oncogenic viruses

Infectious Agents and Cancer, 2012
Background Galectin-9 is a mammalian lectin which possesses immunosuppressive properties. Excessive production of galectin-9 has been reported in two types of human virus-associated diseases chronic hepatitis C and nasopharyngeal carcinoma associated to ...
Barjon Clément, Niki Toshiro, Vérillaud Benjamin, Opolon Paule, Bedossa Pierre, Hirashima Mitsuomi, Blanchin Stéphanie, Wassef Michel, Rosen Hugo R, Jimenez Anne-Sophie, Wei Ming, Busson Pierre   +11 more
doaj   +1 more source

Galectin-9 ameliorates fulminant liver injury

Molecular Medicine Reports, 2017
Fulminant hepatitis is a severe liver disease resulting in hepatocyte necrosis. Galectin‑9 (Gal‑9) is a tandem‑repeat‑type galectin that has been evaluated as a potential therapeutic agent for various diseases that regulate the host immune system. Concanavalin A (ConA) injection into mice results in serious, immune‑mediated liver injury similar to ...
Tadokoro, Tomoko, Morishita, Asahiro, Sakamoto, Teppei, Fujihara, Shintaro, Fujita, Koji, Mimura, Shima, Oura, Kyoko, Nomura, Takako, Tani, Joji, Yoneyama, Hirohito, Iwama, Hisakazu, Himoto, Takashi, Niki, Toshiro, Hirashima, Mitsuomi, Masaki, Tsutomu   +14 more
openaire   +3 more sources

Clinical Significance of Serum Galectin-9 and Soluble CD155 Levels in Patients with Systemic Sclerosis

Journal of Immunology Research, 2018
Signaling through coinhibitory receptors downregulates the immune response to prevent excessive immune activation and maintain optimal immunity and tolerance.
Mami Chihara, Miki Kurita, Yuki Yoshihara, Akihiko Asahina, Koichi Yanaba   +4 more
doaj   +1 more source