Results 51 to 60 of about 8,950,905 (317)

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity

iScience, 2019
Summary: Endogenous extracellular Galectins constitute a novel mechanism of membrane protein organization at the cell surface. Although Galectins are also highly expressed intracellularly, their cytosolic functions are poorly understood.
Laia Querol Cano, Oya Tagit, Yusuf Dolen, Anne van Duffelen, Shannon Dieltjes, Sonja I. Buschow, Toshiro Niki, Mitsuomi Hirashima, Ben Joosten, Koen van den Dries, Alessandra Cambi, Carl G. Figdor, Annemiek B. van Spriel   +12 more
doaj   +1 more source

Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity

International Journal on Biological Sciences, 2023
Although current cancer immunotherapies that target PD-1/PD-L1 immune checkpoint to reinvigorate exhausted T cells have achieved impressive clinical outcomes, only a small proportion of patients respond. New therapeutic targets are therefore needed to be
Shuang-yan Zheng, Jiaming Song, Dongli Linghu, Riyao Yang, Bo-ning Liu, Zhen Xue, Qihui Chen, Chengjie Liu, D. Zhong, M. Hung, Linlin Sun   +10 more
semanticscholar   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]

, 2002
The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Holíkova, Zuzana, Kaltner, Herbert, Motlik, Jan, Gabius, Hans-Joachim, Plzák, Jan, Smetana, Karel, Hercogová, Jana, Dvorankova, Barbora   +7 more
core   +1 more source

Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells

bioRxiv, 2023
Intracellular vesicle transport is essential for cellular homeostasis and is partially mediated by SNARE proteins. Endosomal trafficking to the plasma membrane ensures cytokine secretion in dendritic cells (DCs) and the initiation of immune responses ...
Rui Santalla Méndez, Andrea Rodgers Furones, René Classens, Manon Haverdil, Marta Canela Capdevila, A. van Duffelen, C. G. Spruijt, M. Vermeulen, M. Ter Beest, A. V. van Spriel, L. Q. Cano   +10 more
semanticscholar   +1 more source

Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer [PDF]

, 2005
Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers.
Szöke, Tamas, Furak, Jozsef, André, Sabine, Kayser, Klaus, Horvath, Akos, Baumhäkel, Jan-Dirk, Gabius, Hans-Joachim, Trojan, Imre, Szluha, Kornelia, Tiszlavicz, Laszlo   +9 more
core   +1 more source

Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis [PDF]

, 2021
Galectin-9 is a member of the galectin family of proteins, which were first identified to specifically bind to carbohydrates containing β-galactosides. Galectin-9 is conserved through evolution and recent evidence demonstrated its involvement in innate ...
Sumbayev, Vadim V., Schlichtner, Stephanie, Gibbs, Bernhard F, Yasinska, Inna M., Fasler-Kan, Elizaveta, Gibbs, Bernhard F., Aliu, Nijas, Berger, Steffen M., Meyer, N. Helge, Helge Meyer, N.   +9 more
core   +1 more source

Galectin-9 in autoimmune hepatitis

Medicine, 2019
Abstract Autoimmune hepatitis (AIH) is a disorder of unknown etiology in which immune-mediated liver damage progresses to cirrhosis or hepatocellular carcinoma (HCC). The mainstay therapy for AIH is steroids and other immunosuppressive treatments.
Matsuoka, Naoki, Kozuru, Hideko, Koga, Tomohiro, Abiru, Seigo, Yamasaki, Kazumi, Komori, Atsumasa, Fujita, Yuya, Tenmoku, Junpei, Asano, Tomoyuki, Sato, Shuzo, Suzuki, Eiji, Furuya, Makiko, Kobayashi, Hiroko, Watanabe, Hiroshi, Naganuma, Atsushi, Yoshizawa, Kaname, Shimada, Masaaki, Ario, Keisuke, Yamashita, Haruhiro, Kohno, Hiroshi, Kaneyoshi, Toshihiko, Nakamura, Minoru, Furukawa, Hiroshi, Takahashi, Atsushi, Kawakami, Atsushi, Ohira, Hiromasa, Yatsuhashi, Hiroshi, Migita, Kiyoshi   +27 more
openaire   +2 more sources

Galectin-9 inhibits cell proliferation and induces apoptosis in Jurkat and KE-37 acute lymphoblastic leukemia cell lines via caspase-3 activation

Research in Pharmaceutical Sciences, 2021
Background and purpose: Acute lymphoblastic leukemia (ALL) is a type of cancer of blood and bone marrow characterized by abnormal proliferation of lymphoid progenitor cells. Galectin-9 is a tandem-repeat type galectin expressed in various tumor cells. It
Narges Zargar Balajam, Mahdi Shabani, Mahmoud Aghaei   +2 more
doaj   +1 more source