Results 1 to 10 of about 32,677 (98)

Interrogation of glioma immune microenvironment identifies a non-canonical role for microglial Galectin-9 in tumor cell adhesion and phagocytosis [PDF]

Frontiers in Immunology
Glioma-associated microglia/macrophages (GAMs) have traditionally been described as immunosuppressive. However, within their highly heterogeneous repertoire, pro-phagocytic and cytotoxic subsets with anti-tumoral properties exist.
Pravesh Gupta, Silvana Valdebenito-Silva, Gayatri Kumar, Prashanth Chakrapani, Shivangi Oberai, Shivangi Oberai, Minghao Dang, Hiroshi Katayama, Linghua Wang, Linghua Wang, Linghua Wang, Linghua Wang, Eliseo A. Eugenin, Krishna P. Bhat   +13 more
doaj   +2 more sources

Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion [PDF]

Nature Communications
Galectins play vital roles in cellular processes such as adhesion, communication, and survival, yet the mechanisms underlying their unconventional secretion remain poorly understood.
Wenting Zhang, Cuicui Ji, Xianghua Li, Tianlong He, Wei Jiang, Yukun Liu, Meiling Wu, Yunpeng Zhao, Xuechai Chen, Xiaoli Wang, Jian Li, Haolin Zhang, Juan Wang   +12 more
doaj   +2 more sources

Tim-3/galectin-9 regulates Th1/Th2 cell balance in lipopolysaccharide-induced human lymphocytes [PDF]

Jichu yixue yu linchuang, 2023
Objective To investigate the mechanism of Tim-3/galectin-9 in T helper type 1/2 (Th1/Th2) cell imbalance in lipopolysaccharide(LPS)-induced human lymphocytes.
SUN Xiaoli, ZHANG Jinjin, SONG Fengying, HUANG Yongli, CHEN Lili, XING Yanchao
doaj   +1 more source

The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis

Heliyon, 2023
Background: This study aimed to compare the salivary galectin-3 and galectin-9 levels in periodontitis, gingivitis, and periodontally healthy patients. Methods: This study included 75 non-smokers who were systemically healthy.
Zerrin Barut, Ahmet Mert Nalbantoğlu, Hilal Korkmaz, Zeynep Demir, Mükerrem Hatipoğlu, Aysun Özkan, Şule Bulut   +6 more
doaj   +1 more source

Galectin-9 expression clinically associated with mature dendritic cells infiltration and T cell immune response in colorectal cancer

BMC Cancer, 2022
Background Galectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune microenvironment. However, the immunomodulatory effect of galectin-9 in colorectal cancer (CRC) remains
Yang Wang, Ruizhi Zheng, Yanhui Zhang, Yuhong Guo, Zhenzhen Hui, Peijing Wang, Yan Sun   +6 more
doaj   +1 more source

Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway. [PDF]

PLoS ONE, 2016
Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers.
Yang Wang, Jintang Sun, Chao Ma, Wenjuan Gao, Bingfeng Song, Hao Xue, Weiliang Chen, Xi Chen, Yun Zhang, Qianqian Shao, Qingjie Wang, Lei Zhao, Jia Liu, Xiuwen Wang, Huayang Wang, Yun Zhang, Meixiang Yang, Xun Qu   +17 more
doaj   +1 more source

Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?

Frontiers in Oncology, 2022
The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi, Yuanwei Shi, Danting Tang, Danting Tang, Xiaoqi Li, Xiaoqi Li, Xiaoli Xie, Yufu Ye, Yufu Ye, Lijuan Wang, Lijuan Wang   +10 more
doaj   +1 more source

Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3. [PDF]

PLoS ONE, 2013
Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells.
Masahiro Moritoki, Takeshi Kadowaki, Toshiro Niki, Daisuke Nakano, Genichiro Soma, Hirohito Mori, Hideki Kobara, Tsutomu Masaki, Masakazu Kohno, Mitsuomi Hirashima   +9 more
doaj   +1 more source

Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells

Journal of Biomedical Science, 2020
Background Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role in fibrosis.
Yu-An Hsu, Ching-Yao Chang, Joung-Liang Lan, Ju-Pi Li, Hui-Ju Lin, Chih-Sheng Chen, Lei Wan, Fu-Tong Liu   +7 more
doaj   +1 more source

Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]

PLoS ONE, 2015
Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt, Victor L Thijssen, Johannes Vrolijk, Cornelis D de Kroon, Arko Gorter, Ekaterina S Jordanova   +5 more
doaj   +1 more source