Results 41 to 50 of about 4,258,326 (225)

Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]

, 1998
Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Korabiowska, M., Brinck, U., Bosbach, R., Gabius, Hans-Joachim   +3 more
core   +1 more source

Galectin-9: A Suppressor of Atherosclerosis?

Frontiers in Immunology, 2020
It is no longer controversial that atherosclerosis is a vascular wall chronic inflammatory disease mediated by cells of innate and adaptive immunity. Galectin-9 (Gal-9) seems to be a crucial regulator of T-cell immunity by inducing apoptosis in specific ...
Jian Yu, Ruirui Zhu, Kunwu Yu, Yue Wang, Yan Ding, Yucheng Zhong, Qiutang Zeng   +6 more
doaj   +1 more source

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. [PDF]

PLoS ONE, 2010
Approximately 200 million people throughout the world are infected with hepatitis C virus (HCV). One of the most striking features of HCV infection is its high propensity to establish persistence (approximately 70-80%) and progressive liver injury ...
John A Mengshol, Lucy Golden-Mason, Tomohiro Arikawa, Maxwell Smith, Toshiro Niki, Ryan McWilliams, Jessica A Randall, Rachel McMahan, Michael A Zimmerman, Manu Rangachari, Evgenia Dobrinskikh, Pierre Busson, Stephen J Polyak, Mitsuomi Hirashima, Hugo R Rosen   +14 more
doaj   +1 more source

Data_Sheet_1_The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer.docx

, 2019
Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease.
Svetlana S. Sakhnevych (6559877), Yuri A. Ushkaryov (6943436), Elizaveta Fasler-Kan (6559880), Ana Maria Teuscher Abeleira (6943415), Steffen M. Berger (6943430), Bernhard F. Gibbs (6943433), Ouafa Benlaouer (6943418), Luca Varani (279935), Ludmila Pavlova (6943409), Isabel Gonçalves Silva (6943421), Marco Bardelli (5807642), Inna M. Yasinska (6943406), Vadim V. Sumbayev (6943442), Rohanah Hussain (2161648), Marianne Mosimann (6943424), Elena Klenova (6943439), Anette Teo Hansen Selnø (6943412), Giuliano Siligardi (684292), Dietmar Cholewa (6943427)   +18 more
core   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells

Hematology
The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, the regulation of Tim-3/Galectin-9 on CD4 T cell subsets in multiple myeloma (MM) remains unclear. The aim of this study was to
Rui Zhang, Shuang Chen, Tingting Luo, Sha Guo, Jianhua Qu   +4 more
doaj   +1 more source

Reduced expression of galectin-1 and galectin-9 by leucocytes in asthma patients

, 2012
Supported in part by EU–Mexico FONCICYT-C002-2009-1 ALA/127249, SAF-2008–02635 and SAF-2011–25834 from the Spanish Ministry of Science and Innovation, INDISNET (Redes Moleculares y Celulares en Enfermedades Inflamatorias) S2011/BMD-2332, MEICA (Molecular
Fuente, Hortensia de la, Lamana Domínguez, Amalia, Sanchez-Cuellar, Silvia, Giron, Rosa, Vara, Alicia, Cruz Adalia, Aranzazu, Ancochea, Julio, Cibrian, Danay, Sanchez-Madrid, Francisco   +8 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Cell Death and Disease, 2021
Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck ...
Hanyue Chang, Qiaoshi Xu, Jiayi Li, Mingyu Li, Zhiyuan Zhang, Hailong Ma, Xi Yang   +6 more
doaj   +1 more source

Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma [PDF]

PeerJ, 2020
Background Galectins (Gal) are a family of protein that bind to the β-galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis.
Fei Kong, Meishan Jin, Donghui Cao, Zhifang Jia, Yawen Liu, Jing Jiang   +5 more
doaj   +2 more sources