Results 21 to 30 of about 43,794 (228)

Computational Study of Potential Galectin-3 Inhibitors in the Treatment of COVID-19

Biomedicines, 2021
Galectin-3 is a carbohydrate-binding protein and the most studied member of the galectin family. It regulates several functions throughout the body, among which are inflammation and post-injury remodelling.
Maral Aminpour, Marco Cannariato, Angelica Zucco, Elisabetta Di Gregorio, Simone Israel, Annalisa Perioli, Davide Tucci, Francesca Rossi, Sara Pionato, Silvia Marino, Marco A. Deriu, Kiran K. Velpula, Jack A. Tuszynski   +12 more
doaj   +1 more source

Characterization of Galectin Fusion Proteins with Glycoprotein Affinity Columns and Binding Assays

Molecules, 2023
Galectins are β-galactosyl-binding proteins that fulfill essential physiological functions. In the biotechnological field, galectins are versatile tools, such as in the development of biomaterial coatings or the early-stage diagnosis of cancer diseases ...
Carina Dey, Philip Palm, Lothar Elling
doaj   +1 more source

The two endocytic pathways mediated by the carbohydrate recognition domain and regulated by the collagen-like domain of galectin-3 in vascular endothelial cells. [PDF]

PLoS ONE, 2012
Galectin-3 plays an important role in endothelial morphogenesis and angiogenesis. We investigated the endocytosis of galectin-3 in human vascular endothelial cells and showed that galectin-3 could associate with and internalized into the cells in a ...
Xiaoge Gao, Dan Liu, Yuying Fan, Xinzhi Li, Huiting Xue, Yingyun Ma, Yifa Zhou, Guihua Tai   +7 more
doaj   +1 more source

Binding Characteristics of Galectin-3 Fusion Proteins [PDF]

Glycobiology, 2017
Galectin-3 modulates cell adhesion and signaling events by specific binding and cross-linking galactoside containing carbohydrate ligands. Proteolytic cleavage by metalloproteinases yields in vivo N-terminally truncated galectin-3 still bearing the carbohydrate recognition domain.
Sophia, Böcker, Lothar, Elling
openaire   +2 more sources

Galectin-3 Is a Natural Binding Ligand of MCAM (CD146, MUC18) in Melanoma Cells and Their Interaction Promotes Melanoma Progression

Biomolecules, 2022
Melanoma cell adhesion molecule (MCAM, CD146, MUC18) is a heavily glycosylated transmembrane protein and a marker of melanoma metastasis. It is expressed in advanced primary melanoma and metastasis but rarely in benign naevi or normal melanocytes.
Yaoyu Pang, Ellen Maxwell, Paulina Sindrewicz-Goral, Andrew Shapanis, Shun Li, Mark Morgan, Lu-Gang Yu   +6 more
doaj   +1 more source

TNBC-derived Gal3BP/Gal3 complex induces immunosuppression through CD45 receptor

OncoImmunology, 2023
A preliminary study investigating immunotherapy strategies for aggressive triple negative breast cancer (TNBC) revealed an overexpression of genes involved in the release of extracellular vesicles (EVs).
Annat Raiter, Julia Lipovetsky, Asaf Stenbac, Ido Lubin, Rinat Yerushalmi   +4 more
doaj   +1 more source

A Synthetic Tetramer of Galectin-1 and Galectin-3 Amplifies Pro-apoptotic Signaling by Integrating the Activity of Both Galectins

Frontiers in Chemistry, 2020
Galectin-1 (G1) and galectin-3 (G3) are carbohydrate-binding proteins that can signal apoptosis in T cells. We recently reported that a synthetic tetramer with two G1 and two G3 domains (“G1/G3 Zipper”) induces Jurkat T cell death more potently than G1 ...
Shaheen A. Farhadi, Margaret M. Fettis, Renjie Liu, Gregory A. Hudalla   +3 more
doaj   +1 more source

Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation

Nature Communications, 2022
The carbohydrate binding protein galectin-3 has been linked to diabetes and cancer. Here, authors show that galectin-3 is a sensor of LPS, an important modulator of the mTORC1 signaling, and a critical regulator of glucose metabolism.
Xing Chen, Chunyu Yu, Xinhua Liu, Beibei Liu, Xiaodi Wu, Jiajing Wu, Dong Yan, Lulu Han, Zifan Tang, Xinyi Yuan, Jianqiu Wang, Yue Wang, Shumeng Liu, Lin Shan, Yongfeng Shang   +14 more
doaj   +1 more source

Galectin-3 promotes secretion of proteases that decrease epithelium integrity in human colon cancer cells

Cell Death and Disease, 2023
Galectin-3 is a galactoside-binding protein that is commonly overexpressed in many epithelial cancers. It is increasingly recognized as a multi-functional, multi-mode promoter in cancer development, progression, and metastasis.
Shun Li, David Mark Pritchard, Lu-Gang Yu   +2 more
doaj   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source