Results 11 to 20 of about 43,794 (228)

Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis. [PDF]

Proc Natl Acad Sci U S A, 2022
The major challenges in pancreatic ductal adenocarcinoma (PDAC) management are local or distant metastasis and limited targeted therapeutics to prevent it. To identify a druggable target in tumor secretome and to explore its therapeutic intervention, we performed a liquid chromatography–tandem mass spectrometry (LC-MS/MS)–based proteomic analysis of ...
Choi YS, Kim MJ, Choi EA, Kim S, Lee EJ, Park MJ, Kim MJ, Kim YW, Ahn HS, Jung JY, Jang G, Kim Y, Kim H, Kim K, Kim JY, Hong SM, Kim SC, Chang S.   +17 more
europepmc   +5 more sources

Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection. [PDF]

Int J Mol Sci, 2016
Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined.
Liu KT, Liu YH, Chen YH, Lin CY, Huang CH, Yen MC, Kuo PL.   +6 more
europepmc   +5 more sources

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction. [PDF]

J Clin Med, 2019
Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding ...
Gagno G, Padoan L, Stenner E, Beleù A, Ziberna F, Hiche C, Paldino A, Barbati G, Biolo G, Fiotti N, Not T, Beltrami AP, Sinagra G, Aleksova A.   +13 more
europepmc   +5 more sources

Galectin 3 and its binding protein in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 2003
AbstractObjectiveTo characterize the expression pattern and role of galectin 3 and galectin 3 binding protein (G3BP) in rheumatoid arthritis (RA), in comparison with galectin 1, and to explore whether soluble galectin 3 and G3BP, investigated in serum, synovial fluid, or cell culture supernatant, are associated with disease.MethodsSynovial tissues from
Shiro, Ohshima, Stefan, Kuchen, Christian A, Seemayer, Diego, Kyburz, Astrid, Hirt, Stephanie, Klinzing, Beat A, Michel, Renate E, Gay, Fu-Tong, Liu, Steffen, Gay, Michel, Neidhart   +10 more
openaire   +4 more sources

Galectin 3-binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein. [PDF]

J Biol Chem, 2020
Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretases.
Seki T, Kanagawa M, Kobayashi K, Kowa H, Yahata N, Maruyama K, Iwata N, Inoue H, Toda T.   +8 more
europepmc   +4 more sources

Galectin-3-binding protein and future venous thromboembolism. [PDF]

Res Pract Thromb Haemost
Hansen ES, Edvardsen MS, Aukrust P, Ueland T, Hansen JB, Brækkan SK, Morelli VM.   +6 more
europepmc   +3 more sources

Galectins, antibodies to them and galectin-3 binding protein in systemic lupus erythematosus

Научно-практическая ревматология
The study of galectins is provoked by the search for new biomarkers of activity, clinical manifestations, and disease outcomes of systemic lupus erythematosus (SLE). The presented literature review summarizes the data on the most well-known galectins-1, -
L. V. Kondratyeva, T. V. Popkova, E. L. Nasonov   +2 more
doaj   +2 more sources

Galectin-3 Binding Protein Secreted by Breast Cancer Cells Inhibits Monocyte-Derived Fibrocyte Differentiation. [PDF]

J Immunol, 2015
Abstract To metastasize, tumor cells often need to migrate through a layer of collagen-containing scar tissue which encapsulates the tumor. A key component of scar tissue and fibrosing diseases is the monocyte-derived fibrocyte, a collagen-secreting profibrotic cell.
White MJ, Roife D, Gomer RH.
europepmc   +4 more sources

Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]

, 2018
Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core   +11 more sources

Placental galectin-3 is reduced in early-onset preeclampsia

Frontiers in Physiology, 2022
Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells ...
Manju Kandel, Manju Kandel, Stephen Tong, Stephen Tong, Susan P Walker, Susan P Walker, Ping Cannon, Ping Cannon, Tuong-Vi Nguyen, Tuong-Vi Nguyen, Teresa M. MacDonald, Teresa M. MacDonald, Natalie J. Hannan, Natalie J. Hannan, Tu’uhevaha J. Kaitu’u-Lino, Tu’uhevaha J. Kaitu’u-Lino, Lucy A Bartho, Lucy A Bartho   +17 more
doaj   +1 more source