Results 21 to 30 of about 5,954 (200)

Nuclear Localization of G3BP6 Is Essential for the Flowering Transition in Arabidopsis

Biomolecules, 2023
The Ras GTPase-activating protein SH3 domain-binding protein (G3BP) belongs to the highly conserved family of RNA-binding proteins, which has been well-investigated in humans and animals.
Yuzhu Wang, Zhiyong Li, Xiaoju Liang, Yeling Zhou, Jiansheng Liang   +4 more
doaj   +1 more source

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]

Open Biology, 2016
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte, Lifeng Liu, Marc D. Panas, Bastian Thaa, Nicole Dickson, Benjamin Götte, Adnane Achour, Gerald M. McInerney   +7 more
doaj   +1 more source

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection [PDF]

, 2012
Dynamic, mRNA-containing stress granules (SGs) form in the cytoplasm of cells under environmental stresses, including viral infection. Many viruses appear to employ mechanisms to disrupt the formation of SGs on their mRNAs, suggesting that they represent
Eng, Kai Er, Karlsson Hedestam, Gunilla B., Lulla, Aleksei, McInerney, Gerald M., Merits, Andres, Panas, Marc D., Varjak, Margus   +6 more
core   +4 more sources

Identification of small molecule inhibitors of G3BP-driven stress granule formation

Journal of Cell Biology, 2023
ABSTRACTStress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the paralogs G3BP1 and G3BP2. G3BP1/2 proteins bind mRNAs and thereby promote the condensation of mRNPs into stress granules. Stress granules have been implicated in several disease states, including cancer and neurodegeneration ...
Brian D. Freibaum, James Messing, Haruko Nakamura, Ugur Yurtsever, Jinjun Wu, Hong Joo Kim, Jeff Hixon, Rene Marc Lemieux, Jay Duffner, Walter Huynh, Kathy Wong, Michael White, Christina Lee, Rachel E. Meyers, Roy Parker, J. Paul Taylor   +15 more
openaire   +3 more sources

Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain

Frontiers in Cellular and Infection Microbiology, 2022
Ras-GTPase-activating SH3 domain-binding-proteins 1 (G3BP1) and 2 (G3BP2) are multifunctional RNA-binding proteins involved in stress granule nucleation, previously identified as essential cofactors of Old World alphaviruses.
Aymeric Neyret, Eric Bernard, Olivier Aïqui-Reboul-Paviet, William Bakhache, Patrick Eldin, Laurent Chaloin, Laurence Briant   +6 more
doaj   +1 more source

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells [PDF]

Journal of Visualized Experiments, 2014
SGs can be visualized in cells by immunostaining of specific protein components or polyA+ mRNAs. SGs are highly dynamic and the study of their assembly and fate is important to understand the cellular response to stress. The deficiency in key factors of SGs like G3BP (RasGAP SH3 domain Binding Protein) leads to developmental defects in mice and ...
Martin, S., Chebli, K., Tazi, J.
openaire   +3 more sources

RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodegeneration and Offers New Biomarker-Driven Individualized Treatment Options for (FUS-)ALS. [PDF]

Adv Sci (Weinh)
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Naumann M, Wierschin TM, Kretschmer S, Dash BP, Held A, Salzinger A, Peikert K, Karlek A, Glaß H, Großmann D, Günther R, Petri S, Rödiger A, Brenner D, Pan-Montojo F, Aronica E, Kipp M, Zimyanin V, Sterneckert J, Grehl T, Seebacher ND, Böckers TM, Catanese A, Wainger BJ, Oeckl P, Lee-Kirsch MA, Hermann A.   +26 more
europepmc   +2 more sources

Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]

, 2012
Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Aschenbrenner, Frank, Bug, Gesine, Henschler, Reinhard, Hofmann, Wolf-Karsten, Kampfmann, Manuela, Komor, Martina, Ruthardt, Martin, Rüster, Brigitte Inge, Schwarz, Kerstin   +8 more
core   +1 more source

Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation

Cell Reports, 2023
Summary: Stress granules (SGs) constitute a signaling hub that plays a critical role in type I interferon responses. Here, we report that growth arrest and DNA damage-inducible beta (Gadd45β) act as a positive regulator of SG-mediated interferon ...
W.A. Gayan Chathuranga, Chamilani Nikapitiya, Jae-Hoon Kim, Kiramage Chathuranga, Asela Weerawardhana, Niranjan Dodantenna, Doo-Jin Kim, Haryoung Poo, Jae U. Jung, Chul-Ho Lee, Jong-Soo Lee   +10 more
doaj   +1 more source