Results 21 to 30 of about 4,644 (183)

Rasputin, more promiscuous than ever: a review of G3BP

The International Journal of Developmental Biology, 2004
In this review, we highlight what G3BP's domain structure initially suggested; that G3BPs are "scaffolding" proteins linking signal transduction to RNA metabolism. Whilst it is most attractive to hypothesise about G3BP's role in signalling to mRNA metabolism, it is not known whether all G3BP functions impinge on their RNA-binding activities, so any ...
Irvine, K., Stirling, R., Hume, D., Kennedy, D.   +3 more
openaire   +7 more sources

Chikungunya Virus nsP3 Blocks Stress Granule Assembly by Recruitment of G3BP into Cytoplasmic Foci [PDF]

Journal of Virology, 2012
ABSTRACT Chikungunya virus nonstructural protein nsP3 has an essential but unknown role in alphavirus replication and interacts with Ras-GAP SH3 domain-binding protein (G3BP). Here we describe the first known function of nsP3, to inhibit stress granule assembly by recruiting G3BP into cytoplasmic foci.
Fros, J.J., Domeradzka, N.E., Baggen, J., Geertsema, C., Flipse, J., Vlak, J.M., Pijlman, G.P.   +6 more
openaire   +4 more sources

Analyzing the G3BP-like gene family of Arabidopsis thaliana in early turnip mosaic virus infection [PDF]

Scientific Reports, 2021
The Arabidopsis thaliana genome encodes several genes that are known or predicted to participate in the formation of stress granules (SG). One family of genes encodes for Ras GTPase-activating protein–binding protein (G3BP)-like proteins.
Hendrik Reuper, Khalid Amari, Björn Krenz   +2 more
doaj   +2 more sources

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models [PDF]

Advanced Science
Stress granules (SGs) fulfill a pivotal role in host defense mechanisms, by sequestering both mRNA and protein via the process of liquid–liquid phase separation (LLPS).
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
doaj   +2 more sources

The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART [PDF]

Molecular Cancer Research, 2011
Abstract The regulation of mRNA stability plays an important role in the control of gene expression during cell motility and invasion. We previously reported that GTPase-activating protein [Src homology 3 (SH3) domain] binding protein (G3BP), a marker of cytoplasmic stress granules that are formed in stressed cells and regulate mRNA ...
Keisuke, Taniuchi, Isao, Nishimori, Michael A, Hollingsworth   +2 more
openaire   +3 more sources

The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [PDF]

Journal of Virology
Stress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay.
Ayisha A. Lavender, Oreoluwa Solanke, Hsin-Yao Tang, Hannah E. Peck, Daryll Vanover, Philip J. Santangelo, Margo A. Brinton   +6 more
doaj   +2 more sources

Regulation of physiological and pathological condensates by molecular chaperones. [PDF]

FEBS J
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Akaree N, Secco V, Levy-Adam F, Younis A, Carra S, Shalgi R.   +5 more
europepmc   +2 more sources

The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network

Cell Reports
Summary: Liquid-liquid phase separation (LLPS) mediated by G3BP1/2 proteins and non-translating mRNAs mediates stress granule (SG) assembly. We investigated the phylogenetic evolution of G3BP orthologs from unicellular yeast to mammals and identified ...
Zhiying Yao, Yi Liu, Qi Chen, Xiaoxin Chen, Zhenshuo Zhu, Sha Song, Xianjue Ma, Peiguo Yang   +7 more
doaj   +2 more sources

Intracellular CD24 Inhibits Cell Invasion by Posttranscriptional Regulation of BART through Interaction with G3BP

Cancer Research, 2011
Abstract We report a novel function for the CD24 molecule in pancreatic cancer cells. Intracellular CD24 is associated with stress granules that contain specific mRNAs and RNA-binding proteins that regulate mRNA stability and translation.
Keisuke, Taniuchi, Isao, Nishimori, Michael A, Hollingsworth   +2 more
openaire   +3 more sources

G3BPs in Plant Stress [PDF]

Frontiers in Plant Science, 2021
The sessile nature of plants enforces highly adaptable strategies to adapt to different environmental stresses. Plants respond to these stresses by a massive reprogramming of mRNA metabolism. Balancing of mRNA fates, including translation, sequestration, and decay is essential for plants to not only coordinate growth and development but also to combat ...
Aala A. Abulfaraj, Heribert Hirt, Heribert Hirt, Naganand Rayapuram   +3 more
openaire   +4 more sources