G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction
Genes and Diseases, 2022 GTPase-activating SH3 domain-binding protein 2 (G3BP2) is a mediator that responds to environmental stresses through stress granule formation and is involved in the progression of chronic diseases.
Yaokai Chen, Guixue Wang, Tianhan Li
exaly +5 more sources
Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1 [PDF]
Molecular Oncology, 2022 Mounting evidence suggests that cancer stemness and immunosuppression are related, but the underlying mechanisms behind these are not clear. We previously reported that the stress granule‐associated protein G3BP2 is involved in the regulation of tumor ...
Yanhong Zhang, Changli Yue
exaly +4 more sources
MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2 [PDF]
Frontiers in Genetics, 2021 Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR.
Yanhui He
exaly +5 more sources
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer [PDF]
Molecular Cancer, 2021 Background Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2.
Haichang Li +2 more
exaly +4 more sources
MoleculesG3BP2 is an important RNA-binding protein that belongs to the mammalian Ras-GAP SH3 domain-binding protein (G3BP) family. Its structure enables it to bind to RNA or proteins, regulate nuclear–cytoplasmic shuttling, and participate in various functions ...
Deng Qi
exaly +6 more sources
G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice [PDF]
PeerJ, 2022 Background Spermatogenesis is a complex process that includes mitosis, meiosis, and spermiogenesis. During spermatogenesis, genetic factors play a vital role inthe formation of properly functioning sperm.
Damin Yun +5 more
doaj +5 more sources
Pharmacological Research, 2022 Ras-GAP SH3 domain binding proteins (G3BPs) are a family of RNA-binding proteins that include G3BP1 and G3BP2 in mammals. The protein structure of G3BP2 allows it to bind with RNA or protein and regulate the nucleoplasmic shuttle, therefore participating in a variety of biological functions such as cell growth, differentiation and migration, and RNA ...
Jingjing Wan
exaly +3 more sources
USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC
Cell Death and Disease, 2023 GTPase-activating protein-binding protein 2 (G3BP2) is a key stress granule-associated RNA-binding protein responsible for the formation of stress granules (SGs).
Nan Wang +9 more
doaj +3 more sources
PKCα binds G3BP2 and regulates stress granule formation following cellular stress. [PDF]
PLoS ONE, 2012 Protein kinase C (PKC) isoforms regulate a number of processes crucial for the fate of a cell. In this study we identify previously unrecognized interaction partners of PKCα and a novel role for PKCα in the regulation of stress granule formation during ...
Tamae Kobayashi +4 more
doaj +6 more sources
Stress granule-associated protein G3BP2 regulates breast tumor initiation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Malignant breast tumors consist of supporting stromal cells and epithelial cancerous cells. The cancer cell population is fueled by a reservoir of tumor-initiating cells, and these cells can give rise to the bulk of the tumor.
, Kamila Naxerova, Lance Munn
exaly +3 more sources