Beyond Stress Granules: G3BP1 and G3BP2 Redundantly Suppress SARS-CoV-2 Infection [PDF]
VirusesThe global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed unprecedented challenges to public health and economic stability.
Duo Xu +8 more
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Peptide Transporter 1‐Mediated Dipeptide Transport Promotes Hepatocellular Carcinoma Metastasis by Activating MAP4K4/G3BP2 Signaling Axis [PDF]
Advanced ScienceCancer metastasis is the leading cause of mortality in patients with hepatocellular carcinoma (HCC). To meet the rapid malignant growth and transformation, tumor cells dramatically increase the consumption of nutrients, such as amino acids.
Feifeng Song, Qiyue Wang, Weijiao Fan
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G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction
Genes and Diseases, 2022 GTPase-activating SH3 domain-binding protein 2 (G3BP2) is a mediator that responds to environmental stresses through stress granule formation and is involved in the progression of chronic diseases.
Tianhan Li, Zhengjun Hou, Shiwei Yang
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USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC
Cell Death and Disease, 2023 GTPase-activating protein-binding protein 2 (G3BP2) is a key stress granule-associated RNA-binding protein responsible for the formation of stress granules (SGs).
Nan Wang, Zhenhao Li, Xuekui Liu
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Research Progress on the Biological Function, Disease-Driving Mechanism and Clinical Targeting Strategies of G3BP2 [PDF]
MoleculesG3BP2 is an important RNA-binding protein that belongs to the mammalian Ras-GAP SH3 domain-binding protein (G3BP) family. Its structure enables it to bind to RNA or proteins, regulate nuclear–cytoplasmic shuttling, and participate in various functions ...
Yao Chen +6 more
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Vaccines, 2022 The nucleocapsid (N) protein contributes to key steps of the SARS-CoV-2 life cycle, including packaging of the virus genome and modulating interactions with cytoplasmic components.
Heng Li, Lei Guo, Haijing Shi
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G3BP2-K76 acetylation promotes tumor immunoescape by stabilizing PD-L1 expression in colorectal cancer [PDF]
Cell Communication and SignalingBackground Colorectal cancer (CRC) often evades immune surveillance, leading to poor responses to PD-1/PD-L1 blockade immunotherapy. The underlying mechanisms regulating PD-L1 expression remain incompletely understood.
Haiqing Jie +12 more
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MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer [PDF]
Molecular Cancer, 2021 Background Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2.
Haichang Li, Pei-Hui Lin, Xinyu Zhou
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Long Non-Coding RNA Encoded by Infectious Bronchitis Virus Facilitates Viral Replication via Direct Interaction with G3BP2 and Expression Regulation of a Novel Host MicroRNA [PDF]
Veterinary SciencesLong non-coding RNAs (lncRNAs) encoded by viruses play crucial roles in viral infection, pathogenesis processes, the interaction between viruses and hosts, and immune escape.
Mingjing Zhang +5 more
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LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation [PDF]
mSphereCoxsackievirus B5 (CVB5) is a primary causative agent of hand, foot, and mouth disease (HFMD), and some cases are also associated with severe complications through invasion of the central nervous system, resulting in death.
Jiayu Zhang +11 more
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