G3BP2, a stress granule assembly factor, is dispensable for spermatogenesis in mice [PDF]
PeerJ, 2022 Background Spermatogenesis is a complex process that includes mitosis, meiosis, and spermiogenesis. During spermatogenesis, genetic factors play a vital role inthe formation of properly functioning sperm.
Damin Yun +5 more
doaj +6 more sources
PKCα binds G3BP2 and regulates stress granule formation following cellular stress. [PDF]
PLoS ONE, 2012 Protein kinase C (PKC) isoforms regulate a number of processes crucial for the fate of a cell. In this study we identify previously unrecognized interaction partners of PKCα and a novel role for PKCα in the regulation of stress granule formation during ...
Tamae Kobayashi +4 more
doaj +8 more sources
G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. [PDF]
PLoS Pathogens, 2014 Viral RNA-host protein interactions are critical for replication of flaviviruses, a genus of positive-strand RNA viruses comprising major vector-borne human pathogens including dengue viruses (DENV). We examined three conserved host RNA-binding proteins (
Katell Bidet +2 more
doaj +5 more sources
EPS8L2 drives colorectal cancer cell proliferation and migration via YBX1-dependent activation of G3BP2 transcription [PDF]
Cell Death and DiseaseColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by molecular heterogeneity and limited therapeutic options. Here, we identified EPS8L2 as a novel driver of colorectal tumorigenesis.
Yimeng Duan +11 more
doaj +4 more sources
ROBO1 enhanced esophageal carcinoma cell radioresistance through accelerating G3BP2-mediated eIF3A degradation [PDF]
Cell Death and DiseaseRadiotherapy, as a vital means of esophageal cancer treatment, has benefited countless cancer patients, but owing to the occurrence of radio-resistance, its therapeutic efficiency has been dramatically mitigated.
Chunmei Zhai +3 more
doaj +4 more sources
Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1 [PDF]
Molecular Oncology, 2022 Mounting evidence suggests that cancer stemness and immunosuppression are related, but the underlying mechanisms behind these are not clear. We previously reported that the stress granule‐associated protein G3BP2 is involved in the regulation of tumor ...
Yanhong Zhang +2 more
exaly +4 more sources
Breast Cancer Research, 2023 Background Chemoresistance involves metastasis and aggressiveness of breast cancer (BC). Chemotherapy-elicited exosomes have been reported to be associated with drug resistance and pro-metastatic capacity of BC cells.
Wenjie Xia +8 more
doaj +2 more sources
Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer [PDF]
Molecular Cancer Research, 2018 Abstract Ubiquitin-specific protease 10 (USP10) is known to deubiquitylate its target proteins, mainly to enhance their stabilities. USP10 maintains p53 protein levels and controls epigenetic changes induced by the androgen receptor (AR). GTPase-activating protein-binding protein 2 (G3BP2), an androgen-responsive gene, is known as the
Ken-Ichi, Takayama +4 more
openaire +3 more sources
MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2 [PDF]
Frontiers in Genetics, 2021 Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR.
Haijun Zhao, Yanhui He
doaj +3 more sources
Scientific Reports, 2023 Circular RNAs (circRNAs) play key roles in colorectal cancer (CRC) progression, but little is known about the biological functions of hsa_circRNA_001676 in CRC. Therefore, we explored the potential role of hsa_circRNA_001676 in CRC development.
Qin Hao +7 more
doaj +3 more sources