Results 41 to 50 of about 146 (109)
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, Volume 13, Issue 43, 3 August 2026.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells
Frontiers in Microbiology, 2022 Stress granule formation is induced by numerous environmental stressors, including sodium arsenite treatment and viral infection. Accordingly, stress granules can inhibit viral propagation and function as part of the antiviral host response to numerous ...
Dongbum Kim +11 more
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.Yy Abstract Background Cancer‐associated fibroblasts (CAFs) are key components of the breast cancer tumor microenvironment and mediate communication with tumor cells through extracellular vesicles carrying microRNAs (miRNAs). These miRNAs may influence breast cancer progression by regulating oncogenic and tumor‐suppressive pathways.
Matine Hajarian‐Rezazadeh +4 more
wiley +1 more source
Cell Reports, 2019 Summary: Triple-negative breast cancers (TNBCs) display great diversity in cisplatin sensitivity that cannot be explained solely by cancer-associated DNA repair defects.
Anne Margriet Heijink +7 more
doaj +1 more source
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry
Nature Structural & Molecular BiologyMolecular glue degraders (MGDs) are small-molecule compounds that divert E3 ligases to degrade nonnatural substrates called neosubstrates. Clinically effective MGDs bind cereblon (CRBN), a substrate receptor of the Cullin 4-RING E3 ubiquitin ligase (CRL4CRBN), and recruit neosubstrates to an MGD-induced neosurface on the CRBN CULT domain through ...
Stefano Annunziato +36 more
openaire +3 more sources
IOP Conference Series: Earth and Environmental Science, 2021 Abstract Progress in medical science has shown that cardiovascular pathogenesis is a complex disease with multiple underlying factors. Stress factors such as oxidative stress and oscillatory shear stress (OSS) play a crucial role in the occurrence and development of atherosclerosis as the major cause of cardiovascular diseases (CVD ...
M Safitri +4 more
openaire +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Interferon‐induced transmembrane (IFITM) function in cancer is set by four contextual coordinates, not by family membership. Acute interferon input drives major histocompatibility complex class I (MHC‐I)‐linked immunogenicity; chronic input drives programmed death‐ligand 1 (PD‐L1)‐coupled resistance.
Zhe Liu +4 more
wiley +1 more source
Molecular Cancer, 2018 Background Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B in bladder cancer (BC) remain unknown.
Hongwei Liu +7 more
doaj +1 more source
Nuclear dysfunction in aging and neurodegeneration
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract Neurodegenerative diseases are characterized by a loss of neuronal function and structure, often in a region‐specific manner. Multiple factors contribute to neuronal dysfunction and death, including pathogenic protein buildup, protein mislocalization, and inflammation. Despite extensive research, the common mechanisms driving neurodegeneration
Abbigael Aday +7 more
wiley +1 more source
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells
Cell Death and Disease, 2023 Long noncoding RNAs (lncRNAs) play pivotal roles in tumor development. To identify dysregulated lncRNAs in gastric cancer (GC), we analyzed genome-wide trimethylation of histone H3 lysine 4 (H3K4me3) to screen for transcriptionally active lncRNA genes in
Hiroshi Kitajima +22 more
doaj +1 more source