Results 41 to 50 of about 1,908 (177)

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response

open access: yesiScience, 2022
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is essential for viral replication, making it a promising target for antiviral drug and vaccine development.
Syed Nabeel-Shah   +15 more
doaj   +1 more source

cbVG-dependent SG inhibition is both G3BP1 and G3BP2 dependent.

open access: yes, 2023
(A) Western blot analysis validating A549 G3BP1 KO, G3BP2 KO, and G3BP1/2 dKO. (B) Expression of RSV G gene mRNA relative to the HKI 24 hpi with RSV cbVG-high infection at MOI 1.5 TCID50/cell in A549 control, G3BP1 KO, G3BP2 KO, and G3BP1/2 dKO.
Carolina B. López (12837411)   +3 more
core   +1 more source

Long-Term Transcriptomic Effects of Prebiotics and Synbiotics Delivered In Ovo in Broiler Chickens. [PDF]

open access: yesPLoS ONE, 2016
In ovo delivery of prebiotics and synbiotics in chickens allows for the development of intestinal microflora prior to hatching, which boosts their robustness.
Anna Slawinska   +4 more
doaj   +1 more source

Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules

open access: yesBiomedicines, 2022
Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste   +5 more
doaj   +1 more source

DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling

open access: yesCell Reports, 2023
Summary: Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback.
Ke Zhang   +14 more
doaj   +1 more source

Stress Granule Components G3BP1 and G3BP2 Play a Proviral Role Early in Chikungunya Virus Replication [PDF]

open access: yesJournal of Virology, 2015
ABSTRACT Stress granules (SGs) are protein-mRNA aggregates that are formed in response to environmental stresses, resulting in translational inhibition. SGs are generally believed to play an antiviral role and are manipulated by many viruses, including various alphaviruses. GTPase-activating protein (SH3 domain)-binding protein 1 (G3BP1) is a
Scholte, F.E.M.   +6 more
openaire   +4 more sources

Additional file 1 of MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer

open access: yes, 2021
Additional file 1: Supplementary Figure S1. Human NSCLC patients show elevated both G3BP1 and G3BP2 expression. The whole protein extracts from the additional 10 human NSCLC tumor were subjected to western blot analysis with anti-G3BP1 and G3BP2 ...
Jianjie Ma (11434236)   +16 more
core   +1 more source

G3BP2 valgusünteesi reguleeriv mõju IFITM1 mRNA-le

open access: yes, 2022
Bakalaureuse töö eesmärgiks oli hinnata RNA-seonduvate valkude (G3BP2 ja Caprin-1) mõju valgusünteesile kasutades selleks rakuvaba HEK293FT in vitro translatsioonisüsteemi, mis oli kodeeritud reporter IFITM1 mRNA-ga.
Lass, Minna-Maria
core  

Host Factors Associated with the Sindbis Virus RNA-Dependent RNA Polymerase: Role for G3BP1 and G3BP2 in Virus Replication [PDF]

open access: yesJournal of Virology, 2010
ABSTRACT Sindbis virus (SINV) is the prototype member of the Alphavirus genus, whose members cause severe human diseases for which there is no specific treatment. To ascertain host factors important in the replication of the SINV RNA genome, we generated a SINV expressing nsP4, the viral RNA-dependent RNA ...
Ileana M, Cristea   +8 more
openaire   +2 more sources

Interaction of PKCα with G3BP2, IGF2BP3 and PABPC1.

open access: yes, 2013
(A) PKCα and G3BP2 were immunoprecipitated from SK-N-BE(2)C cell lysates that had been treated with RNase or a RNase inhibitor. Immunoprecipitates were thereafter subjected to Western blot with indicated antibodies. (B) SK-N-BE(2)C cells were transfected
Sofia Winslow (325750)   +4 more
core   +1 more source

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