Results 31 to 40 of about 146 (109)

Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules

Biomedicines, 2022
Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste, Thomas Vercruysse, Steven Boeynaems, Philip Van Damme, Dirk Daelemans, Ludo Van Den Bosch   +5 more
doaj   +1 more source

Long-Term Transcriptomic Effects of Prebiotics and Synbiotics Delivered In Ovo in Broiler Chickens. [PDF]

PLoS ONE, 2016
In ovo delivery of prebiotics and synbiotics in chickens allows for the development of intestinal microflora prior to hatching, which boosts their robustness.
Anna Slawinska, Arkadiusz Plowiec, Maria Siwek, Marcin Jaroszewski, Marek Bednarczyk   +4 more
doaj   +1 more source

DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling

Cell Reports, 2023
Summary: Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback.
Ke Zhang, Miaodan Huang, Ang Li, Jing Wen, Lingli Yan, Yunhao Li, Liman Guo, Kumaran Satyanarayanan Senthil, Yangyang Zhou, Guobing Chen, Yong Liu, Xiaofei Zhang, Xiaoli Yao, Dajiang Qin, Huanxing Su   +14 more
doaj   +1 more source

Stress Granule Components G3BP1 and G3BP2 Play a Proviral Role Early in Chikungunya Virus Replication [PDF]

Journal of Virology, 2015
ABSTRACT Stress granules (SGs) are protein-mRNA aggregates that are formed in response to environmental stresses, resulting in translational inhibition. SGs are generally believed to play an antiviral role and are manipulated by many viruses, including various alphaviruses. GTPase-activating protein (SH3 domain)-binding protein 1 (G3BP1) is a
Scholte, F.E.M., Tas, A., Albulescu, I.C., Zusinaite, E., Merits, A., Snijder, E.J., Hemert, M.J. van   +6 more
openaire   +4 more sources

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway [PDF]

Nature Cell Biology, 2015
Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast tumours, the presence of dense clusters of collagen fibrils indicates increased matrix stiffness and correlates with poor survival. It is unclear how mechanical inputs are transduced into transcriptional outputs to drive tumour progression.
Wei, Spencer C, Fattet, Laurent, Tsai, Jeff H, Guo, Yurong, Pai, Vincent H, Majeski, Hannah E, Chen, Albert C, Sah, Robert L, Taylor, Susan S, Engler, Adam J, Yang, Jing   +10 more
openaire   +5 more sources

Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

Nature Communications, 2023
Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for their activity
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel S. Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajaczkowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernández-Moya, Michael A. Kiebler, Balakumar Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy   +25 more
doaj   +1 more source

Host Factors Associated with the Sindbis Virus RNA-Dependent RNA Polymerase: Role for G3BP1 and G3BP2 in Virus Replication [PDF]

Journal of Virology, 2010
ABSTRACT Sindbis virus (SINV) is the prototype member of the Alphavirus genus, whose members cause severe human diseases for which there is no specific treatment. To ascertain host factors important in the replication of the SINV RNA genome, we generated a SINV expressing nsP4, the viral RNA-dependent RNA ...
Ileana M, Cristea, Heather, Rozjabek, Kelly R, Molloy, Sophiya, Karki, Laura L, White, Charles M, Rice, Michael P, Rout, Brian T, Chait, Margaret R, MacDonald   +8 more
openaire   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Long Non-Coding RNA Encoded by Infectious Bronchitis Virus Facilitates Viral Replication via Direct Interaction with G3BP2 and Expression Regulation of a Novel Host MicroRNA

Veterinary Sciences
Long non-coding RNAs (lncRNAs) encoded by viruses play crucial roles in viral infection, pathogenesis processes, the interaction between viruses and hosts, and immune escape.
Mingjing Zhang, Zhichao Cai, Hongliu An, Rong He, Songbai Zhang, Shouguo Fang   +5 more
doaj   +1 more source

An Analysis of G3BP2 in Non-Small Cell Lung Cancer

Cancers
Background/Objectives: Cancer cells are subjected to various stress conditions and have stress adaptability strategies to survive. Various types of stresses lead to the aggregation of cytoplasmic RNA granules known as stress granules (SGs), seen in normal and tumor cells, and aid in cell survival by avoiding cell apoptosis. G3BP stress granule assembly
Leela S. S. Bandi, Leah Timon, Elena O’Toole, Diarmuid O’Connor, Kristen Andersen, Bashir M. Mohamed, Siobhan Nicholson, Gerard J. Fitzmaurice, Ronan Ryan, Vincent Young, Sinead Cuffe, Stephen P. Finn, Steven G. Gray   +12 more
openaire   +1 more source