Results 31 to 40 of about 1,908 (177)

Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry. [PDF]

Nat Struct Mol Biol
Molecular glue degraders (MGDs) are small-molecule compounds that divert E3 ligases to degrade nonnatural substrates called neosubstrates. Clinically effective MGDs bind cereblon (CRBN), a substrate receptor of the Cullin 4-RING E3 ubiquitin ligase (CRL4CRBN), and recruit neosubstrates to an MGD-induced neosurface on the CRBN CULT domain through ...
Annunziato S, Quan C, Donckele EJ, Lamberto I, Bunker RD, Zlotosch M, Schwander L, Murthy A, Wiedmer L, Staehly C, Matysik M, Gilberto S, Kapsitidou D, Wible D, De Donatis GM, Trenh P, SriRamaratnam R, Strande V, Lieberherr R, Lyon D, Steiner D, Silva J, Almeida R, Dolgikh E, DeMarco B, Tsai J, Sadok A, Zarayskiy V, Walter M, Tiedt R, Lumb KJ, Bonenfant D, Fasching B, Castle JC, Townson SA, Gainza P, Petzold G.   +36 more
europepmc   +4 more sources

Hyperglycemia facilitates EV71 replication: Insights into miR-206-mediated regulation of G3BP2 promoting EV71 IRES activity

Theranostics
Background: Neurotropic virus infections actively manipulate host cell metabolism to enhance virus neurovirulence. Although hyperglycemia is common during severe infections, its specific role remains unclear. This study investigates the impact of hyperglycemia on the neurovirulence of enterovirus 71 (EV71), a neurovirulent virus relying on internal ...
Lai, Rai-Hua, Chow, Yen-Hung, Lin, Yi-Wen, Chung, Nai-Hsiang, Nien, Shu-Wei, Juang, Jyh-Lyh   +5 more
openaire   +3 more sources

EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA

Journal of Orthopaedic Surgery and Research, 2022
Background As a skeletal malignancy, osteosarcoma has high incidence among primary malignant bone tumors. With increasing researches on molecules which mediate cancer progression, molecular mechanism has gradually become the pivot of osteosarcoma ...
Ou Shuang, Jianmin Zhou, Zijun Cai, Longteng Liao, Yuehua Wang, Wenyu Wang, Meng Xu   +6 more
doaj   +1 more source

Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2 [PDF]

Journal of Cell Science, 2012
Wnt signaling is initiated upon binding of Wnts to Frizzleds and their co-receptors LRP5/6. The signal is then propagated to several downstream effectors, mediated by the phosphoprotein scaffold, Dishevelled. We report a novel role for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation.
Bikkavilli, Rama Kamesh, Malbon, Craig C.   +1 more
openaire   +2 more sources

G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner [PDF]

Acta Pharmacologica Sinica
Xianjun Yu, Yi Qin, Yu Xian-Jun
exaly   +2 more sources

Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain

Frontiers in Cellular and Infection Microbiology, 2022
Ras-GTPase-activating SH3 domain-binding-proteins 1 (G3BP1) and 2 (G3BP2) are multifunctional RNA-binding proteins involved in stress granule nucleation, previously identified as essential cofactors of Old World alphaviruses.
Aymeric Neyret, Eric Bernard, Olivier Aïqui-Reboul-Paviet, William Bakhache, Patrick Eldin, Laurent Chaloin, Laurence Briant   +6 more
doaj   +1 more source

Genes related to N6-methyladenosine in the diagnosis and prognosis of idiopathic pulmonary fibrosis

Frontiers in Genetics, 2023
Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary fibrotic disease with unknown etiology and poor outcomes. It severely affects the quality of life.
Jingcheng Zhang, Ying Zhang, Ziyuan Wang, Jiachao Zhao, Zhenyu Li, Keju Wang, Lin Tian, Baojin Yao, Qibiao Wu, Qibiao Wu, Qibiao Wu, Tan Wang, Jing Wang, Jing Wang   +13 more
doaj   +1 more source

Image_2_MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2.TIF

, 2021
Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR.
Haijun Zhao (207007), Yanhui He (433908)
core   +1 more source

Image_1_MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2.TIF

, 2021
Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR.
Haijun Zhao (207007), Yanhui He (433908)
core   +1 more source

Additional file 3 of MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer

, 2021
Additional file 3: Supplementary Figure S3. rhMG53 treatment suppresses SG formation and enhances G3BP2 nuclear translocation in multiple NSCLC cells. SGs were induced by ATO treatment. (A) A549 cells were treated with control (top panels), rhMG53 (10 μg/
Jianjie Ma (11434236), Haichang Li (608267), Pei-Hui Lin (556722), Pranav Gupta (5524016), Dong-Hua Yang (223092), Zhe-Sheng Chen (223107), Serena Li Zhao (11434227), Zhongguang Li (11434230), Robert E. Merritt (11434233), Xiangguang Li (1651876), Renzhi Han (276195), Jing Lu (120666), Tao Tan (204136), Shengcai Wei (8056781), Timothy M. Pawlik (7345382), Xinyu Zhou (736229), Li Xu (108702)   +16 more
core   +1 more source