Results 21 to 30 of about 146 (109)

LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation

MSphere
Coxsackievirus B5 (CVB5) is a primary causative agent of hand, foot, and mouth disease (HFMD), and some cases are also associated with severe complications through invasion of the central nervous system, resulting in death.
Heng Yang, Wei Chen, Tim Mahony
exaly   +3 more sources

G3BP2-K76 acetylation promotes tumor immunoescape by stabilizing PD-L1 expression in colorectal cancer

Cell Communication and Signaling
Background Colorectal cancer (CRC) often evades immune surveillance, leading to poor responses to PD-1/PD-L1 blockade immunotherapy. The underlying mechanisms regulating PD-L1 expression remain incompletely understood.
Haiqing Jie, Xuanhua Yang, Yujie Hou, Wenfeng Liang, Wenxin Li, Ze Li, Dongxu Lei, Hao Xie, Tanxing Cai, Zhiping Chen, Yang Li, Huashan Liu, Liang Kang   +12 more
doaj   +2 more sources

EPS8L2 drives colorectal cancer cell proliferation and migration via YBX1-dependent activation of G3BP2 transcription

Cell Death and Disease
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by molecular heterogeneity and limited therapeutic options. Here, we identified EPS8L2 as a novel driver of colorectal tumorigenesis.
Yimeng Duan, Peixian Li, Yanmei Yang, Guanghua Wu, Hao Xing, Hong Chen, Liangbo Zhao, Lei Liu, Xiao Sun, Shuiling Jin, Luyun He, Benyu Liu   +11 more
doaj   +3 more sources

EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA

Journal of Orthopaedic Surgery and Research, 2022
Background As a skeletal malignancy, osteosarcoma has high incidence among primary malignant bone tumors. With increasing researches on molecules which mediate cancer progression, molecular mechanism has gradually become the pivot of osteosarcoma ...
Ou Shuang, Jianmin Zhou, Zijun Cai, Longteng Liao, Yuehua Wang, Wenyu Wang, Meng Xu   +6 more
doaj   +1 more source

Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2 [PDF]

Journal of Cell Science, 2012
Wnt signaling is initiated upon binding of Wnts to Frizzleds and their co-receptors LRP5/6. The signal is then propagated to several downstream effectors, mediated by the phosphoprotein scaffold, Dishevelled. We report a novel role for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation.
Bikkavilli, Rama Kamesh, Malbon, Craig C.   +1 more
openaire   +2 more sources

Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway

Breast Cancer Research, 2023
Background Chemoresistance involves metastasis and aggressiveness of breast cancer (BC). Chemotherapy-elicited exosomes have been reported to be associated with drug resistance and pro-metastatic capacity of BC cells.
Wenjie Xia, Wuzhen Chen, Chao Ni, Xuli Meng, Jun Wu, Qiong Yang, Hongchao Tang, Hongjun Yuan, Shan Fang   +8 more
doaj   +1 more source

Identification of a non-canonical G3BP-binding sequence in a Mayaro virus nsP3 hypervariable domain

Frontiers in Cellular and Infection Microbiology, 2022
Ras-GTPase-activating SH3 domain-binding-proteins 1 (G3BP1) and 2 (G3BP2) are multifunctional RNA-binding proteins involved in stress granule nucleation, previously identified as essential cofactors of Old World alphaviruses.
Aymeric Neyret, Eric Bernard, Olivier Aïqui-Reboul-Paviet, William Bakhache, Patrick Eldin, Laurent Chaloin, Laurence Briant   +6 more
doaj   +1 more source

Genes related to N6-methyladenosine in the diagnosis and prognosis of idiopathic pulmonary fibrosis

Frontiers in Genetics, 2023
Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive pulmonary fibrotic disease with unknown etiology and poor outcomes. It severely affects the quality of life.
Jingcheng Zhang, Ying Zhang, Ziyuan Wang, Jiachao Zhao, Zhenyu Li, Keju Wang, Lin Tian, Baojin Yao, Qibiao Wu, Qibiao Wu, Qibiao Wu, Tan Wang, Jing Wang, Jing Wang   +13 more
doaj   +1 more source

Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer [PDF]

Molecular Cancer Research, 2018
Abstract Ubiquitin-specific protease 10 (USP10) is known to deubiquitylate its target proteins, mainly to enhance their stabilities. USP10 maintains p53 protein levels and controls epigenetic changes induced by the androgen receptor (AR). GTPase-activating protein-binding protein 2 (G3BP2), an androgen-responsive gene, is known as the
Ken-Ichi, Takayama, Takashi, Suzuki, Tetsuya, Fujimura, Satoru, Takahashi, Satoshi, Inoue   +4 more
openaire   +2 more sources

SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response

iScience, 2022
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is essential for viral replication, making it a promising target for antiviral drug and vaccine development.
Syed Nabeel-Shah, Hyunmin Lee, Nujhat Ahmed, Giovanni L. Burke, Shaghayegh Farhangmehr, Kanwal Ashraf, Shuye Pu, Ulrich Braunschweig, Guoqing Zhong, Hong Wei, Hua Tang, Jianyi Yang, Edyta Marcon, Benjamin J. Blencowe, Zhaolei Zhang, Jack F. Greenblatt   +15 more
doaj   +1 more source