Results 21 to 30 of about 1,908 (177)

Circular RNA circMagi1 regulates the host immune response in respiratory Pseudomonas aeruginosa infection through G3BP2 [PDF]

mBio
Pseudomonas aeruginosa is a major pathogen responsible for hospital-acquired infections, and it is characterized by possessing easy colonization ability, being difficult to clear, and exhibiting pandrug resistance.
Miao Tang, Yongxin Zhang, Rou Xie, Tong Wu, Peng Sun, Yongxiao Luo, Ruihuan Wang, Teng Ma, Yang Yasmine Yang, Yige Zhang, Chaoyu Zou, Xueli Hu, Jing Shirley Li, Huan Liu, Zhuochong Liu, Qianhua Zhang, Yu Tang, Hongliang Li, Yilin Liu, Yang Yang, Jing Li, Ce Bian, Yongjiang Tang, Xikun Zhou   +23 more
doaj   +2 more sources

Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells [PDF]

The EMBO Journal
Upregulation of insulin mRNA translation upon hyperglycemia in pancreatic islet β-cells involves several RNA-binding proteins. Here, we found that G3BP1, a stress granule marker downregulated in islets of subjects with type 2 diabetes, binds to insulin ...
Esteban Quezada, Klaus-Peter Knoch, Jovana Vasiljevic, Annika Seiler, Akshaye Pal, Abishek Gunasekaran, Carla Münster, Daniela Friedland, Eyke Schöniger, Anke Sönmez, Pascal Roch, Carolin Wegbrod, Katharina Ganß, Nicole Kipke, Simon Alberti, Rita Nano, Lorenzo Piemonti, Daniela Aust, Jürgen Weitz, Marius Distler, Michele Solimena   +20 more
doaj   +2 more sources

BAALC‐AS1/G3BP2/c‐Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma [PDF]

Cancer Communications, 2021
Background Long non‐coding RNAs (lncRNAs) have been found to be involved in the development of many cancers. In this study, we aimed to identify the molecular mechanisms of lncRNA BAALC antisense RNA 1 (BAALC‐AS1) in regulating the malignancy of ...
Hongyue Zhang, Yan Wang, Weimin Zhang, Qingnan Wu, Jiawen Fan, Qimin Zhan   +5 more
doaj   +3 more sources

Cross-kingdom miRNA delivery by Panax notoginseng-derived extracellular–like nanoparticles vesicles restores neuronal function after ischemic injury [PDF]

Journal of Nanobiotechnology
Blood-brain barrier (BBB) impermeability remains a major obstacle to the effective treatment of neurological disorders, particularly ischemic stroke. Here, we revealed that plant-derived extracellular vesicle-like nanoparticles (PEVs) offer a promising ...
Yuanyuan Yu, Na Tan, Zhifeng Xu, Zhijian Tan, Tao Wang, Huimin Liu, Le Xu, Dan Lu, Yamei Tang, Hongcheng Mai   +9 more
doaj   +2 more sources

Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis

Molecular Cancer, 2018
Background Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B in bladder cancer (BC) remain unknown.
Hongwei Liu, Junming Bi, Wei Dong, Meihua Yang, Juanyi Shi, Ning Jiang, Tianxin Lin, Jian Huang   +7 more
doaj   +2 more sources

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics [PDF]

Nature Communications
Molecular glue degraders (MGDs) are small molecules that co-opt the ubiquitin-proteasome system to induce degradation of target proteins, including those considered undruggable.
Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine Price, Anand Mayasundari, Lei Yang, Anastasia H. Bednarz, Sophie Machata, Tobias Graef, Denis Bartoschek, Vadim Demichev, Uli Ohmayer, Jun Yang, Henrik Daub, Zoran Rankovic   +20 more
doaj   +2 more sources

Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide

Biochemical and Biophysical Research Communications, 2015
The crystal structure of the NTF2-like domain of the human Ras GTPase SH3 Binding Protein (G3BP), isoform 2, was determined at a resolution of 2.75 Å in complex with a peptide containing a FGDF sequence motif. The overall structure of the protein is highly similar to the homodimeric N-terminal domains of the G3BP1 and Rasputin proteins.
Kristensen, Ole
openaire   +3 more sources

G3BP1 and G3BP2 regulate translation of interferon-stimulated genes: IFITM1, IFITM2 and IFITM3 in the cancer cell line MCF7

Molecular and Cellular Biochemistry, 2019
G3BPs are members of an RNA-binding protein family and their aberrant expression is common in various cancers and there is growing evidence that G3BPs possess antiviral activities and are targeted by various viruses. G3BPs have also been implicated in both stabilization and degradation of specific mRNAs as well as translational control of mRNA targets.
Umber Alam, Derek Kennedy
openaire   +4 more sources

An Analysis of G3BP2 in Non-Small Cell Lung Cancer. [PDF]

Cancers (Basel)
Background/Objectives: Cancer cells are subjected to various stress conditions and have stress adaptability strategies to survive. Various types of stresses lead to the aggregation of cytoplasmic RNA granules known as stress granules (SGs), seen in normal and tumor cells, and aid in cell survival by avoiding cell apoptosis. G3BP stress granule assembly
Bandi LSS, Timon L, O'Toole E, O'Connor D, Andersen K, Mohamed BM, Nicholson S, Fitzmaurice GJ, Ryan R, Young V, Cuffe S, Finn SP, Gray SG.   +12 more
europepmc   +2 more sources

TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation [PDF]

Scientific Reports
Stress granules (SGs) are dense aggregates of RNA and proteins that form in response to various cellular stresses. Virus-induced SGs, known as antiviral SGs (avSGs), play a crucial role in regulating retinoic acid-inducible gene I-like receptors (RLRs ...
Koji Onomoto, Monami Sakai, Miyu Watanabe, Akira Fukao, Yurika Sakamura, Mai Miyao, Takumi Tomohiro, Akio Yamashita, Toshinobu Fujiwara, Tomoko Takahashi, Kumiko Ui-Tei, Mitsutoshi Yoneyama   +11 more
doaj   +2 more sources