Results 51 to 60 of about 1,908 (177)
, 2021 Additional file 2: Supplementary Figure S2. Knockout of MG53 results in elevated stress granule formation in mg53-/- lung. (A) The whole protein extracts from wild type and mg53-/- lung were subjected to western blot analysis with anti-MG53 and G3BP2 ...
Jianjie Ma (11434236) +16 more
core +1 more source
Fear extinction is regulated by the activity of long noncoding RNAs at the synapse
Nature Communications, 2023 Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for their activity
Wei-Siang Liau +25 more
doaj +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
IOP Conference Series: Earth and Environmental Science, 2021 Abstract Progress in medical science has shown that cardiovascular pathogenesis is a complex disease with multiple underlying factors. Stress factors such as oxidative stress and oscillatory shear stress (OSS) play a crucial role in the occurrence and development of atherosclerosis as the major cause of cardiovascular diseases (CVD ...
M Safitri +4 more
openaire +1 more source
Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells
Frontiers in Microbiology, 2022 Stress granule formation is induced by numerous environmental stressors, including sodium arsenite treatment and viral infection. Accordingly, stress granules can inhibit viral propagation and function as part of the antiviral host response to numerous ...
Dongbum Kim +11 more
doaj +1 more source
The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer
Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli +1 more
wiley +1 more source
Cell Reports, 2019 Summary: Triple-negative breast cancers (TNBCs) display great diversity in cisplatin sensitivity that cannot be explained solely by cancer-associated DNA repair defects.
Anne Margriet Heijink +7 more
doaj +1 more source
Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 6, June 2026.Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang +7 more
wiley +1 more source
TM4SF1-AS1 inhibits apoptosis by promoting stress granule formation in cancer cells
Cell Death and Disease, 2023 Long noncoding RNAs (lncRNAs) play pivotal roles in tumor development. To identify dysregulated lncRNAs in gastric cancer (GC), we analyzed genome-wide trimethylation of histone H3 lysine 4 (H3K4me3) to screen for transcriptionally active lncRNA genes in
Hiroshi Kitajima +22 more
doaj +1 more source