Results 71 to 80 of about 146 (109)

Artificial intelligence for risk assessment and outcome prediction in malignant haematology

British Journal of Haematology, Volume 208, Issue 1, Page 25-38, January 2026.
Machine learning models allow for dynamic and scalable risk stratification and outcome prediction. Different modalities of data such as electronic health records, patient genetics or laboratory results can be used as input. ML models autonomously select features weighing their prognostic value. Methods of model explainability in feature selection allow
Jan‐Niklas Eckardt, Wencke Walter, Jan Moritz Middeke, Torsten Haferlach   +3 more
wiley   +1 more source

Molecular surface mimicry enables CRBN to target G3BP2 for degradation

Molecular glue degraders (MGDs) are small molecule compounds that repurpose the ubiquitin-proteasome system to induce degradation of challenging therapeutic targets. Clinically effective MGDs bind cereblon (CRBN), a substrate receptor of the Cullin-4/RING E3 ubiquitin ligase (CRL4CRBN), and impose a gain-of-function activity to recruit, ubiquitinate ...
Stefano Annunziato, Chao Quan, Etienne J. Donckele, Ilaria Lamberto, Richard D. Bunker, Mary Zlotosch, Laura Schwander, Anastasia Murthy, Lars Wiedmer, Camille Staehly, Michelle Matysik, Samuel Gilberto, Despina Kapsitidou, Daric Wible, Gian Marco De Donatis, Peter Trenh, Rohitha SriRamaratnam, Vaik Strande, Reinaldo Almeida, Lena Dolgikh, Bradley DeMarco, Jennifer Tsai, Amine Sadok, Vladislav Zarayskiy, Magnus Walter, Ralph Tiedt, Kevin J. Lumb, Debora Bonenfant, Bernhard Fasching, John C. Castle, Sharon A. Townson, Pablo Gainza, Georg Petzold   +32 more
openaire   +1 more source

Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells

The EMBO Journal
Upregulation of insulin mRNA translation upon hyperglycemia in pancreatic islet β-cells involves several RNA-binding proteins. Here, we found that G3BP1, a stress granule marker downregulated in islets of subjects with type 2 diabetes, binds to insulin ...
Esteban Quezada, Klaus-Peter Knoch, Jovana Vasiljevic, Annika Seiler, Akshaye Pal, Abishek Gunasekaran, Carla Münster, Daniela Friedland, Eyke Schöniger, Anke Sönmez, Pascal Roch, Carolin Wegbrod, Katharina Ganß, Nicole Kipke, Simon Alberti, Rita Nano, Lorenzo Piemonti, Daniela Aust, Jürgen Weitz, Marius Distler, Michele Solimena   +20 more
doaj   +1 more source

Circular RNA circMagi1 regulates the host immune response in respiratory Pseudomonas aeruginosa infection through G3BP2

mBio
Pseudomonas aeruginosa is a major pathogen responsible for hospital-acquired infections, and it is characterized by possessing easy colonization ability, being difficult to clear, and exhibiting pandrug resistance.
Miao Tang, Yongxin Zhang, Rou Xie, Tong Wu, Peng Sun, Yongxiao Luo, Ruihuan Wang, Teng Ma, Yang Yasmine Yang, Yige Zhang, Chaoyu Zou, Xueli Hu, Jing Shirley Li, Huan Liu, Zhuochong Liu, Qianhua Zhang, Yu Tang, Hongliang Li, Yilin Liu, Yang Yang, Jing Li, Ce Bian, Yongjiang Tang, Xikun Zhou   +23 more
doaj   +1 more source

G3BP1 and G3BP2 regulate translation of interferon-stimulated genes: IFITM1, IFITM2 and IFITM3 in the cancer cell line MCF7

Molecular and Cellular Biochemistry, 2019
G3BPs are members of an RNA-binding protein family and their aberrant expression is common in various cancers and there is growing evidence that G3BPs possess antiviral activities and are targeted by various viruses. G3BPs have also been implicated in both stabilization and degradation of specific mRNAs as well as translational control of mRNA targets.
Umber Alam, Derek Kennedy
openaire   +3 more sources

Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy

Neurobiology of Disease, 2006
The biology underlying epileptic brain activity in humans is not well understood and likely depends on changes in gene expression. We performed a microarray transcriptome profiling of 12 anterolateral temporal cortical samples originating from five ...
Dominique Arion, Michael Sabatini, Travis Unger, Jesús Pastor, Lidia Alonso-Nanclares, Inmaculada Ballesteros-Yáñez, Rafael García Sola, Alberto Muñoz, Károly Mirnics, Javier DeFelipe   +9 more
doaj   +1 more source

hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility

Cell Reports
Summary: Although the composition and assembly of stress granules (SGs) are well understood, the molecular mechanisms underlying SG disassembly remain unclear. Here, we identify that heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) is associated
Xiaoli Wang, Xu Fan, Jin Zhang, Fengli Wang, Jingshou Chen, Yujiao Wen, Lingjuan Wang, Tao Li, Huaibiao Li, Heng Gu, Youzhi Zhang, Shuiqiao Yuan   +11 more
doaj   +1 more source

Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules

Viruses, 2015
We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection.
Jonathan D. Dougherty, Wei-Chih Tsai, Richard E. Lloyd   +2 more
doaj   +1 more source

Networks of pre-diagnostic circulating RNA in testicular germ cell tumour

Scientific Reports
Testicular germ cell tumour (TGCT) is a malignancy with known inherited risk factors, affecting young men. We have previously identified several hundred differentially abundant circulating RNAs in pre-diagnostic serum from TGCT cases compared to healthy ...
Joshua Burton, Trine B. Rounge, Trine B. Haugen, Marcin W. Wojewodzic   +3 more
doaj   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source