Results 71 to 80 of about 1,908 (177)
Analysis of the PKCα variant co-precipitated with G3BP2.
, 2013 Lysates from SK-N-BE(2)C neuroblastoma cells were incubated with either PKCα antibody (A) or G3BP2 antibody (B) and precipitated materials were separated by SDS-PAGE.
Sofia Winslow (325750) +4 more
core +1 more source
Signal Transduction and Targeted Therapy, 2023 Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction (MI) heart failure (HF). Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively reversed infarction-
Jingjing Wan +14 more
doaj +1 more source
USP10 in Neurological Disorders: Mechanistic Insights and Emerging Therapeutic Strategies
Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.USP10 is a deubiquitinating enzyme that affects neurological diseases through multiple mechanisms, including the accumulation of toxic proteins, autophagy, and immune responses. In this review, we discuss the structure and characteristics of USP10 and summarize the role of USP10 in neurological disorders.
Celemuge +5 more
wiley +1 more source
, 2018 Supplementary Figure S2. USP10 regulates androgen-dependent signals and G3BP2 protein level in VCaP cells.
Satoru Takahashi (32871) +4 more
core +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
SARS-CoV-2 infection does not trigger SG formation in Vero E6 cells.
, 2023 Vero E6 cells stably expressing TMPRSS2 were infected with SARS-CoV-2 Omicron BA.1 and Wuhan (D614G) variants at MOI 5. After 6, 8 and 16 hpi cells were fixed and stained with antibodies against dsRNA as an infection marker, and eIF3 and G3BP2 as SG ...
Jelle G. Schipper (16866034) +7 more
core +1 more source
Health Science Reports, Volume 9, Issue 1, January 2026.ABSTRACT Background and Aims Ulcerative colitis (UC), a chronic inflammatory bowel disease, causes persistent mucosal inflammation and epithelial dysfunction. Basal progenitor cells (BPCs), critical for intestinal regeneration and mucosal repair, exhibit altered behavior in UC.
Xiaopeng Chen +9 more
wiley +1 more source
Artificial intelligence for risk assessment and outcome prediction in malignant haematology
British Journal of Haematology, Volume 208, Issue 1, Page 25-38, January 2026.Machine learning models allow for dynamic and scalable risk stratification and outcome prediction. Different modalities of data such as electronic health records, patient genetics or laboratory results can be used as input. ML models autonomously select features weighing their prognostic value. Methods of model explainability in feature selection allow
Jan‐Niklas Eckardt +3 more
wiley +1 more source
PKCα, G3BP2, PABPC1 and IGF2BP3 co-localize in stress granules.
, 2013 (A) SK-N-BE(2)C cells were either incubated at 37°C or heat shocked at 44°C for 1 h and endogenous G3BP2, IGF2BP3, and PABPC1 were visualized by immunofluorescence.
Sofia Winslow (325750) +4 more
core +1 more source