Results 91 to 100 of about 146 (109)

G3BP2 facilitates abnormal activation of fibroblast-like synoviocytes through p53 signaling pathway in rheumatoid arthritis

International Immunopharmacology
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and joint destruction. While GTPase-activating protein SH3 domain-binding protein 2 (G3BP2) plays important roles in tumors and other diseases, its function in RA remains unclear.
Yilong Fang, Zhongyao Hu
exaly   +3 more sources

RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2

Oncogene, 2022
RIO Kinase 1 (RIOK1) is involved in various pathologies, including cancer. However, the role of RIOK1 in radioresistance of colorectal cancer (CRC) remains largely unknown. In this study, we reported that RIOK1 was overexpressed in rectal cancer tissue with weaker tumor regression after neoadjuvant chemoradiotherapy (neoCRT).
Yaqi Chen, Sha Zhou, Kairui Wan, Long Yu, Chongchong Zhao, Haiteng Deng, Qingjian Ou, Jiayi Qin, Junbo Hu, Zhenlin Hou   +9 more
openaire   +2 more sources

Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer

Oncogene, 2017
The androgen receptor (AR) has a central role in prostate cancer progression, particularly treatment-resistance disease including castration-resistant prostate cancer. Loss of the p53 tumor suppressor, a nuclear transcription factor, is also known to contribute to prostate malignancy. Here we report that p53 is translocated to the cytoplasm by androgen-
D Ashikari, K Takayama, T Tanaka, Y Suzuki, D Obinata, T Fujimura, T Urano, S Takahashi, S Inoue   +8 more
openaire   +2 more sources

Targeting G3BP2 Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment Via ELF1-MCL1 Axis

Blood, 2023
Venetoclax-based combination therapies have emerged as promising treatments for elderly acute myeloid leukemia (AML) patients. However, venetoclax resistance renders the treatment ineffective, mainly due to the upregulation of MCL1. Thus, new venetoclax-based combination therapy is under development to circumvent venetoclax resistance ...
Zhixiang Chen, Yuanhua Cai, Xiaolin Lai, Xuechun Wang, Xiongbin Yan, Yaping Wang, Fuquan Tu, Wanting Wu, Yang Li, Lili Pan, Yi Zheng, Jinggang Li, Xiaofan Li, Shaoyuan Wang   +13 more
openaire   +1 more source

Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide

Biochemical and Biophysical Research Communications, 2015
The crystal structure of the NTF2-like domain of the human Ras GTPase SH3 Binding Protein (G3BP), isoform 2, was determined at a resolution of 2.75 Å in complex with a peptide containing a FGDF sequence motif. The overall structure of the protein is highly similar to the homodimeric N-terminal domains of the G3BP1 and Rasputin proteins.
openaire   +2 more sources

α-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling

Oncogene, 2019
Identification of molecular alterations driving breast cancer progression is critical for the development of effective therapy. In this study, we show that the level of α-parvin is elevated in triple-negative breast cancer cells. The depletion of α-parvin from triple-negative breast cancer cells effectively inhibits breast cancer cell growth, migration,
Ying, Sun, Yanyan, Ding, Chen, Guo, Chengmin, Liu, Ping, Ma, Shuang, Ma, Zhe, Wang, Jie, Liu, Tao, Qian, Luyao, Ma, Yi, Deng, Chuanyue, Wu   +11 more
openaire   +2 more sources

Exosomal microRNA-363 mediates the destructive effect of M1 macrophages on chondrocytes by repressing G3BP2

Experimental Cell Research
M1 polarization of synovial macrophages contributes to cartilage degeneration and osteoarthritis (OA) development. However, limited knowledge is available about how M1 macrophages affect the biological properties of chondrocytes. This study aimed to explore the role of exosomal microRNAs (miRs) released from M1 macrophages in modulating the ...
Wenteng Si, Hongchao Wei, Wenzhong Chen, Bin Chen, Yu Zhou, Huaguo Zhang   +5 more
openaire   +2 more sources

TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

Oncogene, 2018
Prostate cancer growth is promoted by the gene regulatory action of androgen receptor (AR) and its downstream signals. The aberrant dysfunction of tumor suppressor p53 has an important role in the prognosis of cancer. We previously found that androgen treatments translocate p53 to the cytoplasm.
Ken-ichi Takayama, Takashi Suzuki, Tomoaki Tanaka, Tetsuya Fujimura, Satoru Takahashi, Tomohiko Urano, Kazuhiro Ikeda, Satoshi Inoue   +7 more
openaire   +2 more sources

RanBP2-dependent SUMOylation of G3BP2 inhibits formation, and promotes disassembly, of stress granules

Molecular Biology of the Cell
Stress granules and processing bodies (P-bodies) are dynamic cytoplasmic ribonucleoprotein (RNP) condensates that coordinate translation inhibition, mRNA storage, and decay during cellular stress. Emerging evidence suggests that SUMOylation contributes to the regulation of these RNP granules in human cells, though the underlying mechanisms remain ...
Yifan E. Wang, Javid Guliyev, Sean S.J. Ihn, Gaelen Moore, Fermisk Saleh, Hyun O. Lee, Alexander F. Palazzo   +6 more
openaire   +1 more source

Down-regulation of miR-515-5p contributes to the development of rhabdomyosarcoma through G3BP2

2019
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma found in children and young adults. By screening for potential tumor suppressive microRNAs in two RMS cell lines, we found that miR-515-5p exibited tumor suppressive functions: it is downregulated in a large fraction of RMS biopsies; its overexpression inhibited tumor growth in nude mice and
openaire   +2 more sources