Results 81 to 90 of about 146 (109)

Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

eLife
Cells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar, Sulochan Malla, Vlastimil Martinek, Matthew John Payea, Christopher Tai-Yi Lee, Jessica Martin, Aditya Jignesh Khandeshi, Jennifer L Martindale, Cedric Belair, Manolis Maragkakis   +9 more
doaj   +1 more source

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

Nature Communications
Molecular glue degraders (MGDs) are small molecules that co-opt the ubiquitin-proteasome system to induce degradation of target proteins, including those considered undruggable.
Martin Steger, Gisele Nishiguchi, Qiong Wu, Bjoern Schwalb, Bachuki Shashikadze, Kevin McGowan, Marisa Actis, Anup Aggarwal, Zhe Shi, Jeanine Price, Anand Mayasundari, Lei Yang, Anastasia H. Bednarz, Sophie Machata, Tobias Graef, Denis Bartoschek, Vadim Demichev, Uli Ohmayer, Jun Yang, Henrik Daub, Zoran Rankovic   +20 more
doaj   +1 more source

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Nature Communications
Considerable progress has been made in understanding the molecular host-virus battlefield during SARS-CoV-2 infection. Nevertheless, the assembly and egress of newly formed virions are less understood.
Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun   +13 more
doaj   +1 more source

Cross-kingdom miRNA delivery by Panax notoginseng-derived extracellular–like nanoparticles vesicles restores neuronal function after ischemic injury

Journal of Nanobiotechnology
Blood-brain barrier (BBB) impermeability remains a major obstacle to the effective treatment of neurological disorders, particularly ischemic stroke. Here, we revealed that plant-derived extracellular vesicle-like nanoparticles (PEVs) offer a promising ...
Yuanyuan Yu, Na Tan, Zhifeng Xu, Zhijian Tan, Tao Wang, Huimin Liu, Le Xu, Dan Lu, Yamei Tang, Hongcheng Mai   +9 more
doaj   +1 more source

TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation

Scientific Reports
Stress granules (SGs) are dense aggregates of RNA and proteins that form in response to various cellular stresses. Virus-induced SGs, known as antiviral SGs (avSGs), play a crucial role in regulating retinoic acid-inducible gene I-like receptors (RLRs ...
Koji Onomoto, Monami Sakai, Miyu Watanabe, Akira Fukao, Yurika Sakamura, Mai Miyao, Takumi Tomohiro, Akio Yamashita, Toshinobu Fujiwara, Tomoko Takahashi, Kumiko Ui-Tei, Mitsutoshi Yoneyama   +11 more
doaj   +1 more source

ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation

Neurobiology of Disease
The cytoplasmic Ataxin-2 (ATXN2) protein associates with TDP-43 in stress granules (SG) where RNA quality control occurs. Mutations in this pathway underlie Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis.
Jana Key, Luis-Enrique Almaguer-Mederos, Arvind Reddy Kandi, Nesli-Ece Sen, Suzana Gispert, Gabriele Köpf, David Meierhofer, Georg Auburger   +7 more
doaj   +1 more source

Identification of atrial fibrillation-related genes through transcriptome data analysis and Mendelian randomization

Frontiers in Cardiovascular Medicine
BackgroundAtrial fibrillation (AF) is a common persistent arrhythmia characterized by rapid and chaotic atrial electrical activity, potentially leading to severe complications such as thromboembolism, heart failure, and stroke, significantly affecting ...
Yujun Zhang, Qiufang Lian, Yanwu Nie, Wei Zhao   +3 more
doaj   +1 more source

ZNF692 promotes the migration and response to immunotherapy of clear cell renal cell carcinoma cells by targeting metabolic pathway

Discover Oncology
Clear cell renal cell carcinoma (ccRCC), with high mortality and poor prognosis, is the most common type of renal malignancy. It is necessary to identify new biomarkers that can serve as indicators for the detection of ccRCC at its early stages.
Yuming Liu, Dehua Zeng, Yunzhen Gao
doaj   +1 more source

Hyperglycemia facilitates EV71 replication: Insights into miR-206-mediated regulation of G3BP2 promoting EV71 IRES activity

Theranostics
Background: Neurotropic virus infections actively manipulate host cell metabolism to enhance virus neurovirulence. Although hyperglycemia is common during severe infections, its specific role remains unclear. This study investigates the impact of hyperglycemia on the neurovirulence of enterovirus 71 (EV71), a neurovirulent virus relying on internal ...
Lai, Rai-Hua, Chow, Yen-Hung, Lin, Yi-Wen, Chung, Nai-Hsiang, Nien, Shu-Wei, Juang, Jyh-Lyh   +5 more
openaire   +2 more sources

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Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE mice

Atherosclerosis, 2020
Atherosclerosis is mainly caused by stress in arterial microenvironments, which results in the formation of stress granules as a consequence of the stress response. As the core protein of stress granules, GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) is known to play pivotal roles in tumour initiation, viral infection and Alzheimer's
Kang Zhang, Richard Daniel, Guixue Wang   +2 more
exaly   +4 more sources