Results 101 to 110 of about 1,908 (177)

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Networks of pre-diagnostic circulating RNA in testicular germ cell tumour

Scientific Reports
Testicular germ cell tumour (TGCT) is a malignancy with known inherited risk factors, affecting young men. We have previously identified several hundred differentially abundant circulating RNAs in pre-diagnostic serum from TGCT cases compared to healthy ...
Joshua Burton, Trine B. Rounge, Trine B. Haugen, Marcin W. Wojewodzic   +3 more
doaj   +1 more source

Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules

Viruses, 2015
We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection.
Jonathan D. Dougherty, Wei-Chih Tsai, Richard E. Lloyd   +2 more
doaj   +1 more source

Evaluation of gene expression GTPase activating protein (SH3 domain) binding protein 2 (G3BP2), tissue factor (TF) and its isoform asHTF as possible prognostic markers in head and neck squamous cell carcinoma

, 2009
Proteína 2 ligante de SH3 ativadora da GTPase de Ras (G3BP2) parece estar envolvido em vias importantes de sobrevivência celular como a via do NF-B.
Barbeta, Lilian Pires, Lilian Pires Barbeta   +1 more
core   +1 more source

MERS-CoV infection fails to activate the stress response pathway.

, 2016
(A) Immune fluorescence images of mock-treated an MERS-CoV infected Vero cells. Cells were infected with an MOI of 1 and fixed using 3% paraformaldehyde in PBS at 10h or 24h post infection.
Isabel Sola (218107), Raoul J. de Groot (127117), Robert C. M. Knaap (3254526), Tim J. Dalebout (3254532), Huib H. Rabouw (3254538), Peter J. Bredenbeek (193182), Javier Canton (3254541), Marjolein Kikkert (270862), Luis Enjuanes (146937), Martijn A. Langereis (186265), Frank J. M. van Kuppeveld (17308)   +10 more
core   +1 more source

Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

eLife
Cells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global changes in RNA ...
Showkat Ahmad Dar, Sulochan Malla, Vlastimil Martinek, Matthew John Payea, Christopher Tai-Yi Lee, Jessica Martin, Aditya Jignesh Khandeshi, Jennifer L Martindale, Cedric Belair, Manolis Maragkakis   +9 more
doaj   +1 more source

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Nature Communications
Considerable progress has been made in understanding the molecular host-virus battlefield during SARS-CoV-2 infection. Nevertheless, the assembly and egress of newly formed virions are less understood.
Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun   +13 more
doaj   +1 more source

The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in human breast cancers

, 2002
Ras-GTPase activating protein SH3 domain-binding proteins 1 and 2 (G3BP1 and G3BP2) have recently been reported to be encoded by two separate genes on human chromosomes 5 and 4 respectively and have been implicated in Ras signalling, NFkappaB signalling,
Kennedy, H. D., French, J., Stirling, R., Walsh, M.   +3 more
core   +1 more source

ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation

Neurobiology of Disease
The cytoplasmic Ataxin-2 (ATXN2) protein associates with TDP-43 in stress granules (SG) where RNA quality control occurs. Mutations in this pathway underlie Spinocerebellar Ataxia type 2 (SCA2) and Amyotrophic Lateral Sclerosis.
Jana Key, Luis-Enrique Almaguer-Mederos, Arvind Reddy Kandi, Nesli-Ece Sen, Suzana Gispert, Gabriele Köpf, David Meierhofer, Georg Auburger   +7 more
doaj   +1 more source

Identification of atrial fibrillation-related genes through transcriptome data analysis and Mendelian randomization

Frontiers in Cardiovascular Medicine
BackgroundAtrial fibrillation (AF) is a common persistent arrhythmia characterized by rapid and chaotic atrial electrical activity, potentially leading to severe complications such as thromboembolism, heart failure, and stroke, significantly affecting ...
Yujun Zhang, Qiufang Lian, Yanwu Nie, Wei Zhao   +3 more
doaj   +1 more source