Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity. [PDF]
J VirolAntagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early ...
Alvarado RE +13 more
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NEDDylation promotes stress granule assembly [PDF]
Nature Communications, 2016 Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan +8 more
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Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
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Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes. [PDF]
Cell RepSummary: Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ∼200 nm ...
Demeshkina NA, Ferré-D'Amaré AR.
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Stress granule-defective mutants deregulate stress responsive transcripts.
PLoS Genetics, 2014 To reduce expression of gene products not required under stress conditions, eukaryotic cells form large and complex cytoplasmic aggregates of RNA and proteins (stress granules; SGs), where transcripts are kept translationally inert.
Xiaoxue Yang +9 more
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DEAD-Box Helicase 3 Modulates the Non-Coding RNA Pool in Ribonucleoprotein Condensates During Stress Granule Formation. [PDF]
Noncoding RNAStress granule formation is a type of liquid–liquid phase separation in the cytoplasm, leading to RNA–protein condensates that are associated with various cellular stress responses and implicated in numerous pathologies, including cancer ...
Korunova E +7 more
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13. [PDF]
Nat CommunNon-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear.
Cheng SJ +8 more
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Frontiers in Cell and Developmental Biology, 2021 Metabolic regulation is a necessary component of all stress response pathways, because all different mechanisms of stress-adaptation place high-energy demands on the cell.
Triana Amen +2 more
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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A Hybrid-Body Containing Constituents of Both P-Bodies and Stress Granules Forms in Response to Hypoosmotic Stress in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2016 The cytoplasm of the eukaryotic cell is a highly compartmentalized space that contains a variety of ribonucleoprotein (RNP) granules in addition to its complement of membrane-bound organelles.
Khyati H Shah +3 more
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