Results 1 to 10 of about 70,767 (258)
Frontiers in Cell and Developmental Biology, 2021 Metabolic regulation is a necessary component of all stress response pathways, because all different mechanisms of stress-adaptation place high-energy demands on the cell.
Triana Amen +2 more
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TRIM26-mediated NKRF degradation drives Osimertinib resistance through SNRPD2-dependent stress granule formation in lung adenocarcinoma [PDF]
Cell Death and DiseaseOsimertinib is the standard first-line therapy for EGFR-mutant lung adenocarcinoma; however, the inevitable development of acquired resistance leads to disease progression and treatment failure.
Tao Wang +7 more
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Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells
Frontiers in Microbiology, 2022 Stress granule formation is induced by numerous environmental stressors, including sodium arsenite treatment and viral infection. Accordingly, stress granules can inhibit viral propagation and function as part of the antiviral host response to numerous ...
Dongbum Kim +11 more
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The prion-like protein kinase Sky1 is required for efficient stress granule disassembly
Nature Communications, 2019 The factors regulating stress granule dissolution are not fully understood. Here, the authors identify Sky1 as a stress granule component in yeast, and show that Sky1 kinase activity is required for timely stress granule disassembly during stress ...
Jenifer E. Shattuck +3 more
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Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity [PDF]
Journal of VirologyAntagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early ...
R. Elias Alvarado +13 more
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Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
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RNF144A-VRK2-G3BP1 axis regulates stress granule assembly [PDF]
Cell Death DiscoveryUnder the cellular stress, stress granules (SGs) help survival and proliferation of the cell. Unfortunately, the same SGs help unwanted cancer cells under stressful environment, including anti-cancer chemotherapy treatment.
Sung Wook Kim +5 more
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PARP10 is critical for stress granule initiation. [PDF]
Life Sci Alliance, 2023 Stress granules (SGs) are cytoplasmic biomolecular condensates enriched with RNA and translation factors. They form in response to stress, in part through phosphorylation of the translation initiation factor eIF2α, and are implicated in viral infection, tumorigenesis, and neurodegeneration. Although ADP-ribosylation plays a key role in SG assembly, the
Jayabalan AK, Bhambhani K, Leung AK.
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The autophagy of stress granules
FEBS Letters, 2023 Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One of the proposed mechanisms by which SGs and any associated protein aggregates may become pathological is based upon defects in their autophagic
Ryan, Laura, Rubinsztein, David C
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
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