FAM69C functions as a kinase for eIF2α and promotes stress granule assembly
EMBO Reports, 2023 Stress granules are dynamic cytoplasmic ribonucleoprotein granules that assemble in response to cellular stress. Aberrant formation of stress granules has been linked to neurodegenerative diseases.
Zhongyan Wu, Fan Mei, Yuxin Yin
exaly +2 more sources
Cell, 2020 Summary Stressed cells shut down translation, release mRNA molecules from polysomes, and form stress granules (SGs) via a network of interactions that involve G3BP. Here we focus on the mechanistic underpinnings of SG assembly.
Jordina Guillén-Boixet +2 more
exaly +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Metabolic regulation is a necessary component of all stress response pathways, because all different mechanisms of stress-adaptation place high-energy demands on the cell.
Triana Amen +2 more
doaj +3 more sources
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs. [PDF]
Mol CellStress-induced mRNP condensation is conserved across eukaryotes, resulting in stress granule formation under intense stresses, yet the mRNA composition and function of these condensates remain unclear.
Glauninger H +11 more
europepmc +2 more sources
TRIM26-mediated NKRF degradation drives Osimertinib resistance through SNRPD2-dependent stress granule formation in lung adenocarcinoma [PDF]
Cell Death and DiseaseOsimertinib is the standard first-line therapy for EGFR-mutant lung adenocarcinoma; however, the inevitable development of acquired resistance leads to disease progression and treatment failure.
Tao Wang +7 more
doaj +2 more sources
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner
Science, 2021 Tailoring stress responses When faced with environmental stress, cells respond by shutting down cellular processes such as translation and nucleocytoplasmic transport.
Youngdae Gwon +2 more
exaly +2 more sources
Cell, 2015 SUMMARY Stress granules are membrane-less organelles composed of RNA-binding proteins (RBPs) and RNA. Functional impairment of stress granules has been implicated in amyotrophic lateral sclerosis, frontotemporal dementia and multisystem proteinopathy ...
Jamshid Temirov +2 more
exaly +2 more sources
Differential effect of SARS-CoV-2 infection on stress granule formation in Vero and Calu-3 cells
Frontiers in Microbiology, 2022 Stress granule formation is induced by numerous environmental stressors, including sodium arsenite treatment and viral infection. Accordingly, stress granules can inhibit viral propagation and function as part of the antiviral host response to numerous ...
Dongbum Kim +11 more
doaj +3 more sources
Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity [PDF]
Journal of VirologyAntagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early ...
R. Elias Alvarado +13 more
doaj +2 more sources
The prion-like protein kinase Sky1 is required for efficient stress granule disassembly
Nature Communications, 2019 The factors regulating stress granule dissolution are not fully understood. Here, the authors identify Sky1 as a stress granule component in yeast, and show that Sky1 kinase activity is required for timely stress granule disassembly during stress ...
Jenifer E. Shattuck +3 more
doaj +2 more sources