Results 41 to 50 of about 70,909 (261)

Granule structure influences on force chain development in the slag medium

地质科技通报, 2022
The slag dumps formed by mining activities are irregular granular media. Their particle size gradations are complex and granule structures are unstable.The stress between particles is transferred through the dependently unstable force chain.
Minfeng Lu, Zhaohui Tang, Bo Chai, Ke Ning, Jiewen Zhu, Yi Fang   +5 more
doaj   +1 more source

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Stress granules, which are ubiquitous, non–membrane-bound assemblies of protein and RNA, form when translation initiation is inhibited, contribute to the regulation of gene expression, and are implicated in the pathologies of cancer and neurodegenerative disease. Understanding the mechanisms of stress
Briana, Van Treeck, David S W, Protter, Tyler, Matheny, Anthony, Khong, Christopher D, Link, Roy, Parker   +5 more
openaire   +2 more sources

Viral modulation of stress granules

Virus Research, 2012
Following viral infection, the host responds by mounting a robust anti-viral response with the aim of creating an unfavorable environment for viral replication. As a countermeasure, viruses have elaborated mechanisms to subvert the host response in order to maintain viral protein synthesis and production.
Valiente-Echeverría, Fernando, Melnychuk, Luca, Mouland, Andrew J.   +2 more
openaire   +2 more sources

Plant stress granules and mRNA processing bodies are distinct from heat stress granules [PDF]

The Plant Journal, 2008
SummarySimilar to the situation in mammalian cells and yeast, messenger ribonucleo protein (mRNP) homeostasis in plant cells depends on rapid transitions between three functional states, i.e. translated mRNPs in polysomes, stored mRNPs and mRNPs under degradation.
Christian, Weber, Lutz, Nover, Markus, Fauth   +2 more
openaire   +2 more sources

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Distinct stages in stress granule assembly and disassembly

eLife, 2016
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.
Joshua R Wheeler, Tyler Matheny, Saumya Jain, Robert Abrisch, Roy Parker   +4 more
doaj   +1 more source

Translation Landscape of Stress Granules

Science Advances
Abstract Stress granules, cytoplasmic assemblies of RNA-binding proteins and mRNAs formed during cellular stress, are implicated in translational control. However, their exact functions remain elusive. Here, we employed cryogenic correlative light and electron microscopy to visualize stress granules in their native environment and reconstructed
Yichun Wu, Xing Wang, Lingyu Meng, Zhizhao Liao, Wei Ji, Peipei Zhang, Jie Lin, Qiang Guo   +7 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Fasnall Induces Atypically Transient Stress Granules Independently of FASN Inhibition

iScience, 2020
Summary: Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule ...
Triana Amen, Daniel Kaganovich
doaj   +1 more source