Results 41 to 50 of about 4,657,064 (329)
A bending rigidity parameter for stress granule condensates
Science Advances, 2023 Interfacial tension plays an important role in governing the dynamics of droplet coalescence and determining how condensates interact with and deform lipid membranes and biological filaments.
Jack O. Law +6 more
semanticscholar +1 more source
RNA G-quadruplex organizes stress granule assembly through DNAPTP6 in neurons
Science Advances, 2023 Consecutive guanine RNA sequences can adopt quadruple-stranded structures, termed RNA G-quadruplexes (rG4s). Although rG4-forming sequences are abundant in transcriptomes, the physiological roles of rG4s in the central nervous system remain poorly ...
Sefan Asamitsu +10 more
semanticscholar +1 more source
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication
Cell Discovery, 2021 The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood.
Zhou-Qin Zheng +4 more
semanticscholar +1 more source
Human Molecular Genetics, 2023 Stress granules are membrane-less ribonucleoprotein organelles that assemble upon exposure to stress conditions, but rapidly disassemble upon removal of stress.
Ricardo Gutiérrez-García +6 more
semanticscholar +1 more source
Stress granule formation helps to mitigate neurodegeneration
, 2023 Cellular stress pathways that inhibit translation initiation lead to transient formation of cytoplasmic RNA/protein complexes known as stress granules.
Barmada, SJ +9 more
core +1 more source
Journal of Hematology & Oncology, 2022 Background Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs are expected to be potential diagnostic biomarkers and therapeutic targets for a variety of malignancies.
Xiaolong Wang +12 more
semanticscholar +1 more source
Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Mendelian susceptibility to mycobacterial disease (MSMD) is defined by selective vulnerability to weakly virulent mycobacteria. The 32 known inborn errors of IFN-γ immunity account for MSMD in about half of the patients, and for a smaller ...
Tom Le Voyer +39 more
semanticscholar +1 more source
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress [PDF]
, 2017 Hexanucleotide repeat expansions in the C9ORF72 gene are causally associated with frontotemporal lobar dementia (FTLD) and/or amyotrophic lateral sclerosis (ALS). The physiological function of the normal C9ORF72 protein remains unclear. In this study, we
Maharjan, Niran +3 more
core +1 more source
mRNPs meet stress granules [PDF]
FEBS Letters, 2017 Stress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA‐binding proteins, and have been studied in connection to major cellular events such as protein synthesis as well as disease. Despite the well‐known fact that stress granules encapsulate
Jonathan Sheinberger, Yaron Shav‐Tal
openaire +2 more sources
Bidirectional GABAergic control of AP firing in newly-generated young granule cells of the adult hippocampus [PDF]
, 2015 Gamma-aminobutyric acid (GABA) is the first transmitter which provides synaptic input to newly generated neurons. In the first 2-3 weeks after mitosis, young neurons show an elevated intracellular chloride concentration due to the expression of the NKCC1
Heigele, Stefanie
core +1 more source