Results 61 to 70 of about 4,657,064 (329)

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics [PDF]

, 2017
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules.
Bogaert, E., Kedersha, Nancy, Daelemans, D, Mathias De Decker, Ryan, Veronica H, Tompa, Péter, Jaspers, Tom, Konijnenberg, A., Frank Sobott, Kovács, D., Boeynaems, S., Rousseau, Frederic, Elke Bogaert, Pieter Baatsen, Fawzi, Nicolas L, Bogaert, E, Guharoy, Mainak, Baatsen, Pieter, Van Den Bosch, L, Taylor, JP, Schymkowitz, J, Kolaitis, R-M, Rousseau, F, Schymkowitz, Joost, Thomas Vercruysse, Taylor, J. Paul, De Decker, Mathias, Janke, Abigail M, Nicolas L. Fawzi, Veronica H. Ryan, Impens, Francis, Janke, Abigail M., Timmerman, E., Frederic Rousseau, Van Damme, Philip, Tom Jaspers, Decker, MD, Fawzi, NL, Daelemans, Dirk, Robberecht, Wim, Volkov, A, Van Den Bosch, Ludo, Kovacs, Denes, Kolaitis, Regina-Maria, Regina-Maria Kolaitis, Steven Boeynaems, Robberecht, W, Alex Volkov, Peter Tompa, Ryan, Veronica H., Dirk Daelemans, Baatsen, P, Tompa, P, Volkov, Alex, Wim Robberecht, Joost Schymkowitz, Timmerman, Evy, Boeynaems, S, Sobott, F, Vercruysse, T, Ryan, VH, Mainak Guharoy, Bogaert, Elke, J. Paul Taylor, Konijnenberg, A, Anderson, P, Vercruysse, Thomas, Kovacs, D, Impens, F, Taylor, J Paul, Jaspers, T, Janke, AM, Denes Kovacs, Paul Anderson, Kedersha, N, Evy Timmerman, Francis Impens, Anderson, Paul, Konijnenberg, Albert, Sobott, Frank, Albert Konijnenberg, Guharoy, M, Van Damme, P, Ludo Van Den Bosch, Nancy Kedersha, Philip Van Damme, Timmerman, E, Boeynaems, Steven, Abigail M. Janke, Fawzi, Nicolas L.   +89 more
core   +1 more source

Editorial: Biology of Stress Granules in Plants

Frontiers in Plant Science, 2022
Eukaryotic cells have developed sophisticated mechanisms to survive under ever-changing environments which include compartmentalization of translationally arrested mRNA molecules and proteins into a type of membraneless cytoplasmic foci called stress granules (SGs).
Monika Chodasiewicz, J. C. Jang, Emilio Gutierrez-Beltran, Emilio Gutierrez-Beltran   +3 more
openaire   +6 more sources

Getting stress out of stressed‐out stress granules [PDF]

The EMBO Journal, 2017
Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal , Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase ...
Pratibha Siwach, Daniel Kaganovich
openaire   +3 more sources

Expression of human G3BP1 in E. coli [PDF]

E3S Web of Conferences, 2021
G3BP1 (Ras-GTPase-activating protein SH3 domain-binding protein) is responsible for normal RNA stress granule (SG) assembly and overexpressed in many cancer cells. Deletion of G3BP1 decreases the number and size of SGs.
Yang Ziwei
doaj   +1 more source

Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Alphaviruses are mosquito-borne RNA viruses that cause rash, arthritis, and neurologic disease. Despite a continued risk of outbreaks, there are no licensed interventions for any alphavirus.
A. Jayabalan, Srivathsan Adivarahan, Aakash Koppula, Rachy Abraham, M. Batish, Daniel Zenklusen, D. Griffin, A. Leung   +7 more
semanticscholar   +1 more source

Aspergillus oryzae AoSO is a novel component of stress granules upon heat stress in filamentous fungi. [PDF]

PLoS ONE, 2013
Stress granules are a type of cytoplasmic messenger ribonucleoprotein (mRNP) granule formed in response to the inhibition of translation initiation, which typically occurs when cells are exposed to stress.
Hsiang-Ting Huang, Jun-ichi Maruyama, Katsuhiko Kitamoto   +2 more
doaj   +1 more source

Stress‐induced mRNP granules: Form and function of processing bodies and stress granules [PDF]

WIREs RNA, 2019
In response to stress, cells must quickly reprogram gene expression to adapt and survive. This is achieved in part by altering levels of mRNAs and their translation into proteins. Recently, the formation of two stress‐induced messenger ribonucleoprotein (mRNP) assemblies named stress granules and processing bodies has been postulated to directly impact
Anna R. Guzikowski, Yang S. Chen, Brian M. Zid   +2 more
openaire   +4 more sources

Plant Stress Granules: Trends and Beyond [PDF]

Frontiers in Plant Science, 2021
Stress granules (SGs) are dynamic membrane-less condensates transiently assembled through liquid–liquid phase separation (LLPS) in response to stress. SGs display a biphasic architecture constituted of core and shell phases. The core is a conserved SG fraction fundamental for its assembly and consists primarily of proteins with intrinsically disordered
Maruri Lopez, Israel, Figueroa, Nicolas E., Hernandez-Sanchez, Itzell E., Chodasiewicz, Monika   +3 more
openaire   +4 more sources

The Role of Ubiquitin in Regulating Stress Granule Dynamics

Frontiers in Physiology, 2022
Stress granules (SGs) are dynamic, reversible biomolecular condensates, which assemble in the cytoplasm of eukaryotic cells under various stress conditions.
Laura J Krause, Maria Georgina Herrera, K. Winklhofer   +2 more
semanticscholar   +1 more source

Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery

Cell Reports, 2018
Summary: How cells adapt to varying environmental conditions is largely unknown. Here, we show that, in budding yeast, the RNA-binding and stress granule protein Pub1 has an intrinsic property to form condensates upon starvation or heat stress and that ...
Sonja Kroschwald, Matthias C. Munder, Shovamayee Maharana, Titus M. Franzmann, Doris Richter, Martine Ruer, Anthony A. Hyman, Simon Alberti   +7 more
doaj   +1 more source