Results 71 to 80 of about 4,657,064 (329)

m6A-binding YTHDF proteins promote stress granule formation

Nature Chemical Biology, 2020
Diverse RNAs and RNA-binding proteins form phase-separated, membraneless granules in cells under stress conditions. However, the role of the prevalent mRNA methylation, m6A, and its binding proteins in stress granule (SG) assembly remain unclear.
Ye Fu, X. Zhuang
semanticscholar   +1 more source

Inhibition of HSF1 and SAFB Granule Formation Enhances Apoptosis Induced by Heat Stress [PDF]

, 2021
Stress resistance mechanisms include upregulation of heat shock proteins (HSPs) and formation of granules. Stress-induced granules are classified into stress granules and nuclear stress bodies (nSBs).
Ohtsuki, Takashi, Watanabe, Kazunori, Kazunori Watanabe, Takashi Ohtsuki   +3 more
core   +2 more sources

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism

iScience, 2020
Summary: Maintaining a balance between protein degradation and protein synthesis is necessary for neurodevelopment. Although the E3 ubiquitin ligase anaphase promoting complex and its regulatory subunit Cdh1 (Cdh1-APC) has been shown to regulate learning
Arielle N. Valdez-Sinon, Austin Lai, Liang Shi, Carly L. Lancaster, Avanti Gokhale, Victor Faundez, Gary J. Bassell   +6 more
doaj   +1 more source

Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2010
The regulation of translation and mRNA degradation in eukaryotic cells involves the formation of cytoplasmic mRNP granules referred to as P-bodies and stress granules.
Kylie D Swisher, Roy Parker
doaj   +1 more source

Hsp90‐mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

EMBO Reports, 2021
Stress granules (SGs) are dynamic condensates associated with protein misfolding diseases. They sequester stalled mRNAs and signaling factors, such as the mTORC1 subunit raptor, suggesting that SGs coordinate cell growth during and after stress. However,
L. Mediani, Francesco Antoniani, Veronica Galli, J. Vinet, A. Carrá, Ilaria Bigi, Vadreenath Tripathy, Tatiana Tiago, Marco Cimino, G. Leo, Triana Amen, Daniel Kaganovich, Cristina Cereda, O. Pansarasa, J. Mandrioli, P. Tripathi, D. Troost, E. Aronica, J. Buchner, A. Goswami, J. Sterneckert, S. Alberti, Serena Carra   +22 more
semanticscholar   +1 more source

A switch for stress granule assembly [PDF]

Journal of Cell Biology, 2016
![Figure][1] Cells overexpressing USP10 (green) fail to form stress granules (magenta) when translation initiation is inhibited. [Kedersha et al.][2] describe how phosphorylation and the competition between mutually exclusive binding partners regulate G3BP’s ability to mediate ...
openaire   +2 more sources

A novel G3BP1-GFP reporter human lung cell system enabling real-time monitoring of stress granule dynamics for in vitro lung toxicity assessment

Ecotoxicology and Environmental Safety
Under various cellular stress conditions, including exposure to toxic chemicals, RNA-binding proteins (RBPs), including Ras GTPase-activating protein-binding protein 1 (G3BP1), aggregate and form stress granule complexes, which serve as hallmarks of ...
Sangsoo Lee, Seung-Yeon Kim, Eunhye Kwon, Sunkyung Choi, Da-Min Jung, Kee K. Kim, Eun-Mi Kim   +6 more
doaj   +1 more source

Granule structure influences on force chain development in the slag medium

地质科技通报, 2022
The slag dumps formed by mining activities are irregular granular media. Their particle size gradations are complex and granule structures are unstable.The stress between particles is transferred through the dependently unstable force chain.
Minfeng Lu, Zhaohui Tang, Bo Chai, Ke Ning, Jiewen Zhu, Yi Fang   +5 more
doaj   +1 more source

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Nature Cell Biology, 2021
Cells respond to stress by blocking translation, rewiring metabolism and forming transient messenger ribonucleoprotein assemblies called stress granules (SGs). After stress release, re-establishing homeostasis and disassembling SGs requires ATP-consuming
Gea Cereghetti, C. Wilson-Zbinden, V. Kissling, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, P. Picotti, D. Drummond, U. Sauer, Reinhard Dechant, M. Peter   +12 more
semanticscholar   +1 more source

Stress granules: Guardians of cellular health and triggers of disease

Neural Regeneration Research
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs (mRNAs) and regulating protein synthesis.
Meghal Desai, Keya Gulati, Manasi Agrawal, Shruti Ghumra, Pabitra K. Sahoo   +4 more
doaj   +1 more source