Results 51 to 60 of about 4,657,064 (329)
EMBO Journal, 2021 Tudor staphylococcal nuclease (TSN; also known as Tudor‐SN, p100, or SND1) is a multifunctional, evolutionarily conserved regulator of gene expression, exhibiting cytoprotective activity in animals and plants and oncogenic activity in mammals.
Emilio Gutiérrez-Beltrán +7 more
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Stress granule assembly in vivo is deficient in the CNS of mutant TDP-43 ALS mice.
Human Molecular Genetics, 2022 Responding effectively to external stress is crucial for neurons. Defective stress granule dynamics has been hypothesized as one of the pathways that renders motor neurons in amyotrophic lateral sclerosis (ALS) more prone to early death. Specifically, it
Alicia Dubinski +5 more
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, 2020 The capacity of cells to organize complex biochemical reactions in intracellular space is a fundamental organizational principle of life. Key to this organization is the compartmentalization of the cytoplasm into distinct organelles, which is frequently achieved through intracellular membranes.
Min-Seok, Song, Elda, Grabocka
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Principles and Properties of Stress Granules [PDF]
Trends in Cell Biology, 2016 Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs) that form from mRNAs stalled in translation initiation. Stress granules form through interactions between mRNA-binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions as
David S W, Protter, Roy, Parker
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PLoS Pathogens, 2021 Cytoplasmic stress granules (SGs) are generally triggered by stress-induced translation arrest for storing mRNAs. Recently, it has been shown that SGs exert anti-viral functions due to their involvement in protein synthesis shut off and recruitment of ...
Bo Gao +14 more
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The deacetylase HDAC6 is an essential component of stress granules and plays a critical role in the cellular response to stress [PDF]
, 2007 The reversible acetylation of histones has a critical role in transcriptional regulation. Likewise reversible acetylation of non-histones proteins is also important for other cellular processes.
Kwon, So Hee
core +1 more source
Regulated protein aggregation: stress granules and neurodegeneration
Molecular Neurodegeneration, 2012 The protein aggregation that occurs in neurodegenerative diseases is classically thought to occur as an undesirable, nonfunctional byproduct of protein misfolding. This model contrasts with the biology of RNA binding proteins, many of which are linked to
Wolozin Benjamin
doaj +1 more source
Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation
bioRxiv, 2022 Stress granules (SGs) are cytoplasmic condensates that often form as part of the cellular antiviral response. Despite the growing interest in understanding the interplay between SGs and other biological condensates and viral replication, the role of SG ...
Stacia M. Dolliver +5 more
semanticscholar +1 more source
The Integral Role of RNA in Stress Granule Formation and Function
Frontiers in Cell and Developmental Biology, 2021 Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein (RNP) assemblies whose primary function is to promote cell survival by condensing translationally stalled mRNAs, ribosomal components, translation initiation factors ...
Danae Campos-Melo +3 more
semanticscholar +1 more source
Stress Granules and Virus Replication [PDF]
Future Virology, 2011 Viruses are dependent on the cellular translation machinery for protein synthesis. Part of the innate immune response to infection is activation of the stress kinase PKR which phosphorylates the alpha subunit of the initiation factor eIF2. This results in inhibition of translation and is intended to block virus replication.
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