Results 51 to 60 of about 70,909 (261)

Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. [PDF]

PLoS ONE, 2011
Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear.
Twila A Mason, Elena Kolobova, Jiang Liu, Joseph T Roland, Chin Chiang, James R Goldenring   +5 more
doaj   +1 more source

Stress granules, P-bodies and cancer [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2015
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize post-transcriptional control mechanisms to re-program gene expression in ways that enhance cell survival. Stress granules and processing bodies are RNA-containing granules that contribute to this process by modulating cellular signaling pathways, metabolic ...
Paul, Anderson, Nancy, Kedersha, Pavel, Ivanov   +2 more
openaire   +2 more sources

Stress granules: functions and mechanisms in cancer

Cell & Bioscience, 2023
AbstractStress granules (SGs) are non-enveloped structures formed primarily via protein and RNA aggregation under various stress conditions, including hypoxia and viral infection, as well as oxidative, osmotic, and heat-shock stress. SGs assembly is a highly conserved cellular strategy to reduce stress-related damage and promote cell survival.
Huan Zhou, Jing Luo, Kelin Mou, Lin Peng, Xiaoyue Li, Yulin Lei, Jianmei Wang, Sheng Lin, Yuhao Luo, Li Xiang   +9 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Dynamics of mRNA entry into stress granules [PDF]

Nature Cell Biology, 2019
Stressed eukaryotic cells store mRNAs in protein-rich condensates called stress granules. Using single-molecule tracking techniques to examine how mRNAs enter stress granules, a new study shows that mRNAs make transient contacts with the granule surface before stable association, and become largely immobile after entry.
Chih-Yung, Lee, Geraldine, Seydoux
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The p97 adaptor p47/NSFL1C is necessary for stress granule dissolution after heat stressThe p97 adaptor p47/NSFL1C is necessary for stress granule dissolution after heat stress [PDF]

Open Biology
Stress granules form in response to diverse cellular perturbations to sequester translation components until the stress is resolved. Stress granules are composed of RNA–protein assemblies in membrane-delimited structures and must be rapidly disassembled ...
Michelle A. Johnson, Richa Khanna, Sirisha Mukkavalli, Ly Nguyen, Malavika Raman   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Cytoplasmic circular dsDNA is a key constituent of stress granules

eLife
Stress granules are large cytoplasmic bodies formed in response to environmental insults by eukaryotic cells. Stress granule formation is key for post-stress recovery, and many diseases and infections are characterized by dysregulation of these ...
Natalia A Demeshkina, Adrian R Ferré-D'Amaré   +1 more
doaj   +1 more source

Hypoxia-induced mitochondrial stress granules

Cell Death & Disease, 2023
AbstractPerturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia-induced mitochondrial protein aggregation in C. elegans, we found that sublethal hypoxia, sodium azide, or heat shock-induced abundant ethidium bromide staining mitochondrial granules
Chun-Ling Sun, Marc Van Gilst, C. Michael Crowder   +2 more
openaire   +3 more sources