Results 31 to 40 of about 4,657,064 (329)
PARP10 is critical for stress granule initiation. [PDF]
Life Sci Alliance, 2023 Stress granules (SGs) are cytoplasmic biomolecular condensates enriched with RNA and translation factors. They form in response to stress, in part through phosphorylation of the translation initiation factor eIF2α, and are implicated in viral infection, tumorigenesis, and neurodegeneration. Although ADP-ribosylation plays a key role in SG assembly, the
Jayabalan AK, Bhambhani K, Leung AK.
europepmc +4 more sources
The autophagy of stress granules
FEBS Letters, 2023 Our understanding of stress granule (SG) biology has deepened considerably in recent years, and with this, increased understanding of links has been made between SGs and numerous neurodegenerative diseases. One of the proposed mechanisms by which SGs and any associated protein aggregates may become pathological is based upon defects in their autophagic
Ryan, Laura, Rubinsztein, David C
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Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules
Biomedicines, 2022 Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste +5 more
doaj +1 more source
Identification of small molecule inhibitors of G3BP-driven stress granule formation
bioRxiv, 2023 Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the paralogs G3BP1 and G3BP2. G3BP1/2 proteins bind mRNAs and thereby promote the condensation of mRNPs into stress granules.
Brian D. Freibaum +15 more
semanticscholar +1 more source
A Hybrid-Body Containing Constituents of Both P-Bodies and Stress Granules Forms in Response to Hypoosmotic Stress in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2016 The cytoplasm of the eukaryotic cell is a highly compartmentalized space that contains a variety of ribonucleoprotein (RNP) granules in addition to its complement of membrane-bound organelles.
Khyati H Shah +3 more
doaj +1 more source
Stress granules and neurodegeneration [PDF]
Nature Reviews Neuroscience, 2019 Recent advances suggest that the response of RNA metabolism to stress has an important role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral sclerosis, frontotemporal dementias and Alzheimer disease. RNA-binding proteins (RBPs) control the utilization of mRNA during stress, in part through the formation of ...
Benjamin Wolozin, Pavel Ivanov
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Biomolecular phase separation in stress granule assembly and virus infection
Acta Biochimica et Biophysica Sinica, 2023 Liquid-liquid phase separation (LLPS) has emerged as a crucial mechanism for cellular compartmentalization. One prominent example of this is the stress granule.
Yi Liu +3 more
semanticscholar +1 more source
Current Biology, 2023 Cytoplasmic stress granules (SGs) are phase-separated membrane-less organelles that form in response to various stress stimuli. SGs are mainly composed of non-canonical stalled 48S preinitiation complexes. In addition, many other proteins also accumulate
Daichi Fujikawa +9 more
semanticscholar +1 more source
Cell Cycle, 2012 Cell growth and proliferation are fundamental processes in living organisms and are dynamically controlled by environmental cues. TOR complex 1 (TORC1) is a central protein kinase involved in the regulation of cell growth in response to a wide variety of cellular states and is the target of the immunosuppressant and anticancer drug rapamycin.
Takahara, Terunao, Maeda, Tatsuya
openaire +2 more sources
Nature Immunology, 2022 Interleukin-33 (IL-33), an epithelial cell-derived cytokine that responds rapidly to environmental insult, has a critical role in initiating airway inflammatory diseases.
Wen Chen +25 more
semanticscholar +1 more source