Results 21 to 30 of about 4,657,064 (329)

Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation [PDF]

Cell Reports, 2017
Most cellular stresses induce protein translation inhibition and stress granule formation. Here, using Drosophila S2 cells, we investigate the role of G3BP/Rasputin in this process.
Angelica Aguilera-Gomez, Margarita Zacharogianni, Marinke M. van Oorschot, Heide Genau, Rianne Grond, Tineke Veenendaal, Kristina S. Sinsimer, Elisabeth A. Gavis, Christian Behrends, Catherine Rabouille   +9 more
doaj   +2 more sources

Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo [PDF]

bioRxiv, 2021
Stress granules are phase separated assemblies formed around mRNAs whose identities remain elusive. The techniques available to identify the RNA content of stress granules rely on their physical purification, and are therefore not suitable for single ...
W. van Leeuwen, M. VanInsberghe, Nico Battich, Fredrik Salmén, A. van Oudenaarden, C. Rabouille   +5 more
semanticscholar   +2 more sources

Distinct stages in stress granule assembly and disassembly

eLife, 2016
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell.
Joshua R Wheeler, Tyler Matheny, Saumya Jain, Robert Abrisch, Roy Parker   +4 more
doaj   +2 more sources

In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model

Brain, 2020
Many RNA-binding proteins, including TDP-43, FUS, and TIA1, are stress granule components, dysfunction of which causes amyotrophic lateral sclerosis (ALS).
Fengchao Wang, Runze Chen, Dawei Meng
exaly   +2 more sources

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

Cell, 2018
Summary Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common ...
Ke Zhang, Kathleen M Cunningham, Alyssa N Coyne   +2 more
exaly   +2 more sources

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

Molecular Cell, 2018
Summary In amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD), cytoplasmic aggregates of hyperphosphorylated TDP-43 accumulate and colocalize with some stressgranule components, but how pathological TDP-43 aggregation is nucleated ...
Leeanne Mcgurk, Lin Guo, Jelena Mojsilovic-Petrovic   +2 more
exaly   +2 more sources

ULK1/2 Regulates Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

Molecules and Cells, 2019
Summary Disturbances in autophagy and stress granule dynamics have been implicated as potential mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet, the roles of core autophagy proteins in IBM and stress granule dynamics remain
Bo Wang, Brian A. Maxwell, J. Joo, Youngdae Gwon, James Messing, A. Mishra, T. Shaw, Amber L. Ward, Honghu Quan, S. Sakurada, S. Pruett-Miller, Tulio E. Bertorini, P. Vogel, Hong-Joo Kim, Junmin Peng, J. Taylor, M. Kundu   +16 more
semanticscholar   +2 more sources

eIF5A promotes translation elongation, polysome disassembly and stress granule assembly.

PLoS ONE, 2010
Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed to environmental stress. We have identified ornithine decarboxylase (ODC), an enzyme required for polyamine synthesis, and eIF5A, a polyamine (hypusine ...
Chi Ho Li, Takbum Ohn, Pavel Ivanov, Sarah Tisdale, Paul Anderson   +4 more
doaj   +2 more sources

Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13

Nature Communications
Non-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear.
Shang-Jung Cheng, Temitope Gafaar, Jijin R. A. Kuttiyatveetil, Aleksandr Sverzhinsky, Carla Chen, Minghui Xu, Allison Lilley, John M. Pascal, Anthony K. L. Leung   +8 more
doaj   +2 more sources

RNF144A-VRK2-G3BP1 axis regulates stress granule assembly [PDF]

Cell Death Discovery
Under the cellular stress, stress granules (SGs) help survival and proliferation of the cell. Unfortunately, the same SGs help unwanted cancer cells under stressful environment, including anti-cancer chemotherapy treatment.
Sung Wook Kim, Jae Lee, Kyung Won Jo, Young-Hun Jeong, Won Sik Shin, Kyong-Tai Kim   +5 more
doaj   +2 more sources