Results 11 to 20 of about 4,657,064 (329)
The stress granule transcriptome reveals principles of mRNA accumulation in stress granules [PDF]
Molecular Cell, 2017 SUMMARY Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases.
A. Khong +5 more
semanticscholar +5 more sources
Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]
Cell Stress, 2019 Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
doaj +4 more sources
RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Stress granules, which are ubiquitous, non–membrane-bound assemblies of protein and RNA, form when translation initiation is inhibited, contribute to the regulation of gene expression, and are implicated in the pathologies of cancer and neurodegenerative disease. Understanding the mechanisms of stress
Briana Van Treeck +5 more
semanticscholar +4 more sources
SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. [PDF]
PLoS Genetics, 2015 The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that,
Siqi Hu +10 more
doaj +2 more sources
Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2017 Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required ...
Meaghen Rollins +7 more
doaj +2 more sources
Nature Precedings, 2010 AbstractOverexpressed EGFP-FMRP has been used as a substitute for endogenous fragile X mental retardation protein (FMRP) in protein-protein interaction studies, and in studies concerning the composition, the formation and the localization of neuronal granules.
Robert Denman, Robert Denman
core +4 more sources
The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner [PDF]
Life Science Alliance, 2019 PI3K and p38 act in a hierarchical manner to enhance mTORC1 activity and stress granule formation; although PI3K is the main driver, the impact of p38 gets apparent as PI3K activity declines.
Alexander Martin Heberle +12 more
doaj +2 more sources
Stress granule formation helps to mitigate neurodegeneration
Nucleic Acids ResearchCellular stress pathways that inhibit translation initiation lead to transient formation of cytoplasmic RNA/protein complexes known as stress granules.
M. R. Glineburg +10 more
semanticscholar +3 more sources
Cell Reports, 2017 Summary: Low-complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases.
Marie C. Lechler +8 more
doaj +2 more sources
Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling
Viruses, 2020 Viruses must hijack cellular translation machinery to express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses result in the global inhibition of translation and the storage of stalled mRNAs, into RNA ...
Matthew J. Brownsword +4 more
doaj +2 more sources