Results 41 to 50 of about 4,644 (183)

Control of Fetal Growth and Neonatal Survival by the RasGAP-Associated Endoribonuclease G3BP [PDF]

Molecular and Cellular Biology, 2005
The regulation of mRNA stability plays a major role in the control of gene expression during cell proliferation, differentiation, and development. Here, we show that inactivation of the RasGAP-associated endoribonuclease (G3BP)-encoding gene leads to embryonic lethality and growth retardation.
Latifa, Zekri, Karim, Chebli, Hélène, Tourrière, Finn C, Nielsen, Thomas V O, Hansen, Abdelhaq, Rami, Jamal, Tazi   +6 more
openaire   +2 more sources

p26 is sorted into G3BP phase separations that restrict PEMV2 accumulation.

, 2021
(A) Graphical representation of predicted intrinsic disorder in A. thaliana G3BP using IUPRED [53]. G3BP contains an N-terminal NTF2 domain and C-terminal RNA Recognition Motif (RRM). (B) Following agroinfiltration, G3BP or ΔNTF2 expression patterns were
Dana J. Garrison (11457791), Jared P. May (5988455), Shelby L. Brown (11457788)   +2 more
core   +1 more source

Contrasting Pathology of the Stress Granule Proteins TIA-1 and G3BP in Tauopathies [PDF]

Journal of Neuroscience, 2012
Stress induces aggregation of RNA-binding proteins to form inclusions, termed stress granules (SGs). Recent evidence suggests that SG proteins also colocalize with neuropathological structures, but whether this occurs in Alzheimer's disease is unknown.
Tara, Vanderweyde, Haung, Yu, Megan, Varnum, Liqun, Liu-Yesucevitz, Allison, Citro, Tsuneya, Ikezu, Karen, Duff, Benjamin, Wolozin   +7 more
openaire   +2 more sources

The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation [PDF]

Biochemical Journal, 2010
MK-STYX [MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein] is a pseudophosphatase member of the dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases). MK-STYX is catalytically inactive due to the absence of two amino acids from the signature motif that are essential for phosphatase ...
Hinton, Shantá D., Myers, Michael P., Roggero, Vincent R., Allison, Lizabeth A., Tonks, Nicholas K.   +4 more
openaire   +2 more sources

Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner

Frontiers in Immunology, 2019
Background: Microvesicles (MVs) expressing the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP) may play a pathogenic role in systemic lupus erythematosus (SLE).
Niclas Stefan Rasmussen, Niclas Stefan Rasmussen, Christoffer Tandrup Nielsen, Søren Jacobsen, Claus Henrik Nielsen   +4 more
doaj   +1 more source

Crystal structures of the human G3BP1 NTF2-like domain visualize FxFG Nup repeat specificity. [PDF]

PLoS ONE, 2013
Ras GTPase Activating Protein SH3 Domain Binding Protein (G3BP) is a potential anti-cancer drug target implicated in several cellular functions. We have used protein crystallography to solve crystal structures of the human G3BP1 NTF2-like domain both ...
Tina Vognsen, Ingvar Runár Møller, Ole Kristensen   +2 more
doaj   +1 more source

G3BP isoforms differentially affect stress granule assembly and gene expression during cellular stress. [PDF]

Mol Biol Cell
Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these membraneless organelles is driven by the condensation of RNA and RNA-binding proteins such as G3BPs.
Liboy-Lugo JM, Espinoza CA, Sheu-Gruttadauria J, Park JE, Xu A, Jowhar Z, Gao AL, Carmona-Negrón JA, Wittmann T, Jura N, Floor SN.   +10 more
europepmc   +2 more sources

Large G3BP-induced granules trigger eIF2α phosphorylation

Molecular Biology of the Cell, 2012
Stress granules are large messenger ribonucleoprotein (mRNP) aggregates composed of translation initiation factors and mRNAs that appear when the cell encounters various stressors. Current dogma indicates that stress granules function as inert storage depots for translationally silenced mRNPs until the cell signals for renewed translation and stress ...
Reineke, Lucas C., Dougherty, Jon D., Pierre, Philippe, Lloyd, Richard E.   +3 more
openaire   +2 more sources

A review of studies of the proteomes of circulating microparticles: key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus

Clinical Proteomics, 2017
Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, cancer, cardiovascular, and autoimmune diseases
Christoffer T. Nielsen, Ole Østergaard, Niclas S. Rasmussen, Søren Jacobsen, Niels H. H. Heegaard   +4 more
doaj   +1 more source

Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing

Journal of Virology, 2020
Old World alphaviruses comprise several medically relevant viruses, including chikungunya virus and Ross River virus. Recurrent outbreaks and the lack of antivirals and vaccines demand ongoing research to fight the emergence of these infectious diseases. In this context, a thorough investigation of virus-host interactions is critical.
Benjamin Götte, Age Utt, Rennos Fragkoudis, Andres Merits, Gerald M. McInerney   +4 more
openaire   +3 more sources