Results 41 to 50 of about 5,954 (200)

Antibody response in vaccinated pregnant mares to recent G3BP[12] and G14P[12] equine rotaviruses

Acta Veterinaria Scandinavica, 2012
Background Both the G3P[12] and the G14P[12] type of equine group A rotavirus (RVA) have recently become predominant in many countries, including Japan. G3 types are classified further into G3A and G3B.
Nemoto Manabu, Tsunemitsu Hiroshi, Murase Harutaka, Nambo Yasuo, Sato Shinsuke, Orita Yasuhiro, Imagawa Hiroshi, Bannai Hiroshi, Tsujimura Koji, Yamanaka Takashi, Matsumura Tomio, Kondo Takashi   +11 more
doaj   +1 more source

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly [PDF]

, 2014
Stress granules (SGs) are mRNA-protein aggregates induced during stress, which accumulate in many neurodegenerative diseases. Previously, the autophagy-lysosome pathway and valosin-containing protein (VCP), key players of the protein quality control (PQC)
A Kuma, A Poletti, B Bukau, B Ossareh-Nazari, BK Saha, C Boyault, C Dargemont, C Kraft, CJ Rodriguez-Ortiz, D Amore, D C Rubinsztein, D Seigneurin-Berny, DJ Klionsky, F F Morelli, GD Watts, H Meyer, H Richly, H Tourriere, HJ Kim, HL Zhou, J Liu, J Vinet, JO Johnson, JR Buchan, JS Ju, JS Ju, JS Ju, K Fujii, K Moreau, K Thedieck, LC Reineke, M Takahashi, ME Lindquist, N Gilks, N Hosokawa, N Kedersha, NG Farny, P Anderson, P Anderson, Q Defenouillere, Q Ding, R Mazroui, R Verma, RC Piper, S Carra, S De Biasi, S J Seguin, S Kwon, SR Kimball, T Jacobson, T Ohn, TF Chou, TH Clausen, U Schubert, V Athanasopoulos, V Cherkasov, V Kirkin, VI Korolchuk, WJ Kim, Y Kabeya, Y Kawaguchi, Y Nishida, YE Kim, YR Li   +63 more
core   +2 more sources

The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation [PDF]

Biochemical Journal, 2010
MK-STYX [MAPK (mitogen-activated protein kinase) phospho-serine/threonine/tyrosine-binding protein] is a pseudophosphatase member of the dual-specificity phosphatase subfamily of the PTPs (protein tyrosine phosphatases). MK-STYX is catalytically inactive due to the absence of two amino acids from the signature motif that are essential for phosphatase ...
Hinton, S. D., Myers, M. P., Roggero, V. R., Allison, L. A., Tonks, N. K.   +4 more
openaire   +3 more sources

Selenite Targets eIF4E-Binding Protein-1 to Inhibit Translation Initiation and Induce the Assembly of Non-Canonical Stress Granules [PDF]

, 2012
Stress granules (SGs) are large cytoplasmic ribonucleoprotein complexes that are assembled when cells are exposed to stress. SGs promote the survival of stressed cells by contributing to the reprogramming of protein expression as well as by blocking pro ...
Anderson, Paul Joseph, Fujimura, Ken, Sasaki, Atsuo T.   +2 more
core   +1 more source

Rasputin, more promiscuous than ever: a review of G3BP

The International Journal of Developmental Biology, 2004
In this review, we highlight what G3BP's domain structure initially suggested; that G3BPs are "scaffolding" proteins linking signal transduction to RNA metabolism. Whilst it is most attractive to hypothesise about G3BP's role in signalling to mRNA metabolism, it is not known whether all G3BP functions impinge on their RNA-binding activities, so any ...
Irvine, K., Stirling, R., Hume, D., Kennedy, D.   +3 more
openaire   +4 more sources

A review of studies of the proteomes of circulating microparticles: key roles for galectin-3-binding protein-expressing microparticles in vascular diseases and systemic lupus erythematosus

Clinical Proteomics, 2017
Subcellular microvesicles (MVs) have attracted increasing interest during the past decades. While initially considered as inert cellular debris, several important roles for MVs in physiological homeostasis, cancer, cardiovascular, and autoimmune diseases
Christoffer T. Nielsen, Ole Østergaard, Niclas S. Rasmussen, Søren Jacobsen, Niels H. H. Heegaard   +4 more
doaj   +1 more source

The Role of Ubiquitin in Regulating Stress Granule Dynamics

Frontiers in Physiology, 2022
Stress granules (SGs) are dynamic, reversible biomolecular condensates, which assemble in the cytoplasm of eukaryotic cells under various stress conditions.
Laura J. Krause, Laura J. Krause, Maria G. Herrera, Konstanze F. Winklhofer, Konstanze F. Winklhofer   +4 more
doaj   +1 more source

Analysis of subcellular G3BP redistribution during rubella virus infection

Journal of General Virology, 2012
Rubella virus (RUBV) replicates slowly and to low titre in vertebrate cultured cells, with minimal cytopathology. To determine whether a cellular stress response is induced during such an infection, the formation of Ras-GAP-SH3 domain-binding protein (G3BP)-containing stress granules (SGs) in RUBV-infected cells was examined.
Jason D, Matthews, Teryl K, Frey
openaire   +2 more sources

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy [PDF]

, 2017
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...
A Gautier, A Ivanova, A Salonen, A Utt, AC Register, AE Firth, B Meason, B Thaa, BM Kummerer, C Li, C Schilte, C Smalley, CB Muller, CJ Sheppard, D Moradpour, D Ross-Thriepland, DY Kim, E Born van den, E Frolova, E Herker, E Park, EI Frolova, F Chaumont de, FE Scholte, FE Scholte, G Camus, G Lukinavicius, G Shi, G Shin, G Yang, GP Li, H Gong, H Malet, H Nakabayashi, H Tourriere, H Vihinen, H Vihinen, H Wang, HJ Yang, I De, I Frolov, IM Cristea, J Peranen, JE Snyder, JH Strauss, JJ Fros, JJ Fros, K Bojkowska, K Onomoto, K Tsetsarkin, KM Dean, L Eckei, L Pohjala, M Eckhardt, M Neuvonen, M Neuvonen, M Ruiz-Guillen, MD Panas, MD Panas, MD Panas, ML Rajamaki, MW LaStarza, N Tamberg, NF Rose, NJ Foy, P Bieling, P Laakkonen, P Targett-Adams, R Abdelnabi, R Gorchakov, RL McPherson, S Martin, S Mueller, SC Weaver, T Ahola, T Fujimoto, T Klein, WR Hardy, Y Fujimoto, Y Miyanari, YF Wang   +80 more
core   +1 more source

Control of Fetal Growth and Neonatal Survival by the RasGAP-Associated Endoribonuclease G3BP [PDF]

Molecular and Cellular Biology, 2005
The regulation of mRNA stability plays a major role in the control of gene expression during cell proliferation, differentiation, and development. Here, we show that inactivation of the RasGAP-associated endoribonuclease (G3BP)-encoding gene leads to embryonic lethality and growth retardation.
Latifa, Zekri, Karim, Chebli, Hélène, Tourrière, Finn C, Nielsen, Thomas V O, Hansen, Abdelhaq, Rami, Jamal, Tazi   +6 more
openaire   +2 more sources