Results 51 to 60 of about 4,644 (183)
The Role of Ubiquitin in Regulating Stress Granule Dynamics
Frontiers in Physiology, 2022 Stress granules (SGs) are dynamic, reversible biomolecular condensates, which assemble in the cytoplasm of eukaryotic cells under various stress conditions.
Laura J. Krause +4 more
doaj +1 more source
Rasputin a decade on and more promiscuous than ever? A review of G3BPs
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019 Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BPs, also known as Rasputin) are a family of RNA binding proteins that regulate gene expression in response to environmental stresses by controlling mRNA stability and translation. G3BPs appear to facilitate this activity through their role in stress granules for which they are considered a
Alam, Umber, Kennedy, Derek
openaire +3 more sources
, 2012 Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Schwarz, Kerstin +8 more
core +1 more source
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH
Open Biology, 2023 G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation ...
Tim Schulte +16 more
doaj +1 more source
G3BP-nsP3 complexes bind viral G RNA in CHIKV-infected cells.
, 2016 (A) Colocalization of CHIKV nsP3-Cherry (pseudocolored in green) fusion proteins with CHIKV G RNA. Images are presented as MIP of 6 x-y sections (1 μm) through the middle plane of nucleus. Bars: 10 and 3 μm.
Dal Young Kim (732823) +6 more
core +1 more source
Molecular model of G3BP/FGDF interaction.
, 2015 (A) G3BP-NTF2 (PDB ID: 4FCM) with modelled peptide LTFGDFDE (yellow sticks). The protein is shown as the surface colored according to the electrostatic potential (red: acidic, blue: basic).
Tatiana Sandalova (690366) +6 more
core +1 more source
Arthritis Research & Therapy, 2022 Objective There is an urgent need to identify novel biomarkers of LN to reflect renal histological changes. This study aims to investigate urinary G3BP levels in LN patients and their association with renal disease activity both clinically and ...
Huihua Ding +9 more
doaj +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization [PDF]
Molecular and Cellular Biology, 2001 Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not quiescent cells. G3BP exclusively cleaves between cytosine and adenine (CA) after a specific interaction with RNA through the carboxyl-terminal RRM-type RNA ...
H, Tourrière +6 more
openaire +2 more sources
USP10 binds G3BP via a conserved FGDF motif.
, 2015 (A) Alignment of the N-terminal 80 amino acid residues of higher eukaryote USP10. Human (NM_005153.2), mouse (NP_033488.1), naked mole rat (XP_004842781.1), frog (NP_001080643.1), zebrafish (XP_685621.5).
Tatiana Sandalova (690366) +6 more
core +1 more source