Results 51 to 60 of about 152 (124)

The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART [PDF]

Molecular Cancer Research, 2011
Abstract The regulation of mRNA stability plays an important role in the control of gene expression during cell motility and invasion. We previously reported that GTPase-activating protein [Src homology 3 (SH3) domain] binding protein (G3BP), a marker of cytoplasmic stress granules that are formed in stressed cells and regulate mRNA ...
Keisuke, Taniuchi, Isao, Nishimori, Michael A, Hollingsworth   +2 more
openaire   +2 more sources

Different protein composition and functional properties of adeno-associated virus-6 vector manufactured from the culture medium and cell lysates

Molecular Therapy: Methods & Clinical Development, 2014
Vectors based on recombinant adeno-associated viruses (rAAV) attract a growing interest for human gene therapy. Recently, it was shown that many rAAV serotypes produced by transient transfection of human embryonic kidney 293 cell line (HEK293) are ...
Jerome Denard, Christine Jenny, Véronique Blouin, Philippe Moullier, Fedor Svinartchouk   +4 more
doaj   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Stress granule-related genes during embryogenesis of an invertebrate chordate

Frontiers in Cell and Developmental Biology
Controlling global protein synthesis through the assembly of stress granules represents a strategy adopted by eukaryotic cells to face various stress conditions.
Laura Drago, Alessandro Pennati, Ute Rothbächer, Ryuji Ashita, Seika Hashimoto, Ryota Saito, Shigeki Fujiwara, Loriano Ballarin   +7 more
doaj   +1 more source

Getah Virus in Review: An Emerging Zoonotic Arbovirus

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Getah virus (GETV), a zoonotic virus, belongs to Togaviridae, Alphavirus. GETV leads to diarrhea in piglets and dysfunction of the reproductive system in sows, with pregnant sows potentially experiencing abortion, fetal death, or weak offspring, causing a severe impact on the livestock industry and resulting in economic losses.
Zhengyi Qiu, Duo Zhang, Qingmiao Fan, Zhihao Hu, Haobin Xie, Nan Li, Pengpeng Xiao, Shao-Lun Zhai   +7 more
wiley   +1 more source

Genome-Wide Identification of G3BP Family in U’s Triangle Brassica Species and Analysis of Its Expression in B. napus

Plants
The RasGAP SH3 domain binding protein (G3BP) is a highly conserved family of proteins in eukaryotic organisms that coordinates signal transduction and post-transcriptional gene regulation and functions in the formation of stress granules.
Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue   +13 more
doaj   +1 more source

MiR-124-3p Suppresses the Dysfunction of High Glucose-Stimulated Endothelial Cells by Targeting G3BP2

Frontiers in Genetics, 2021
Background: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. MicroRNAs (miRNAs), members of non-coding RNAs, have been frequently reported to regulate various diseases including DR.
Haijun Zhao, Yanhui He
doaj   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus

Parasites & Vectors, 2015
Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros, Corinne Geertsema, Karima Zouache, Jim Baggen, Natalia Domeradzka, Daniël M. van Leeuwen, Jacky Flipse, Just M. Vlak, Anna-Bella Failloux, Gorben P. Pijlman   +9 more
doaj   +1 more source

Wnt signalling antagonizes stress granule assembly through a Dishevelled-dependent mechanism

Biology Open, 2012
Summary Cells often respond to diverse environmental stresses by inducing stress granules (SGs) as an adaptive mechanism. SGs are generally assembled as a result of aggregation of mRNAs stalled in a translational pre-initiation complex, mediated by a set
Pabitra K. Sahoo, Prayag Murawala, Pravin T. Sawale, Manas R. Sahoo, Mukesh M. Tripathi, Swati R. Gaikwad, Vasudevan Seshadri, Jomon Joseph   +7 more
doaj   +1 more source