Results 61 to 70 of about 4,644 (183)

Serum and urinary Galectin-3 binding protein (G3BP) as novel biomarkers in lupus nephritis

The Egyptian Journal of Internal Medicine
Background One potentially fatal complication of systemic lupus erythematosus (SLE) is lupus nephritis (LN) which requires invasive renal biopsy for diagnosis and monitoring. Non-invasive biomarkers are needed. Galectin-3 binding protein (G3BP) has shown
Amr Mohamed Skoot, Medhat Abd El Megied Ghazy, Nahla Abdel El Aziz Nosair, Mohamed Khaled Mohamed Abd ElAal   +3 more
doaj   +1 more source

Enhanced stress tolerance through reduction of G3BP and suppression of stress granules [PDF]

, 2020
SUMMARY Stress granules (SG) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SG act as a protective mechanism to cope with acute stress, but persistent SG have cytotoxic effects that are associated with several age-related diseases.
Lee, Anna K., Klein, Jonathon, Tacer, Klementina Fon, Lord, Tessa, Oatley, Melissa J., Oatley, Jon M., Porter, Shaina N., Pruett-Miller, Shondra M., Tikhonova, Elena B., Karamyshev, Andrey L., Yang, Peiguo, Kim, Hong Joo, Taylor, J. Paul, Potts, Patrick Ryan   +13 more
openaire   +1 more source

The Network of Interactions between the Porcine Epidemic Diarrhea Virus Nucleocapsid and Host Cellular Proteins

Viruses, 2022
Host–virus protein interactions are critical for intracellular viral propagation. Understanding the interactions between cellular and viral proteins may help us develop new antiviral strategies.
Jianwei Zhou, Yonghui Qiu, Jie Zhao, Yongxia Wang, Ning Zhu, Dedong Wang, Yongqiu Cui, Jinshuo Guo, Tong Sun, Ying Ji, Zhi Wu, Penghui Zeng, Jingyi Li, Xufei Feng, Lei Hou, Jue Liu   +15 more
doaj   +1 more source

The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli, Bünyamin Akgül   +1 more
wiley   +1 more source

Immunohistochemical co-localisation of FMRP, GW182 and G3BP in human fetal ovaries at 15 wga.

, 2016
A. Yellow signal indicates co-expression of G3BP and GW182. Cyan signal indicates co-expression of GW182 and FMRP. Magenta signal indicates co-expression of G3BP and FMRP. White signal indicates co-expression of G3BP, GW182 and FMRP. B.
Panagiotis Filis (3190431), Richard A. Anderson (64013), Hazel Kinnell (3190434), Nicola K. Gray (270672), Andrew J. Childs (218564), Victoria Tessyman (3190428), Roseanne Rosario (130971)   +6 more
core   +1 more source

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo, Yoon Dae Han, Linda Bojmar, Kyung‐A Kim, Yurin Seo, Taeyul K. Kim, Suho Lee, Yeleem Kim, Hye Bin Choi, Yujin H. Lim, Chae Hyun Kim, Alexander Sandberg, Chuanwen Fan, Pernille Lauritzen, Henrik Molina, Christopher Peralta, Jacob B. Geri, Colin Burdette, Dai Hoon Han, Heon Yung Gee, Insuk Lee, Jeon‐Soo Shin, Hyunwook Kim, Leon Li, Gabriel C. Tobias, Inbal Wortzel, Sang Joon Shin, Hyo‐Il Jung, Min Goo Lee, Soonmyung Paik, Robert E. Schwartz, Joong Bae Ahn, David Lyden, Han Sang Kim   +33 more
wiley   +1 more source

Any single FXR or G3BP protein supports virus replication.

, 2016
(A, B) A single, ectopically expressed FXR or G3BP protein supports replication of VEEV and CHIKV, respectively. Single FXR or G3BP-GFP proteins were stably expressed in Fxr tKO or G3bp dKO cells, respectively. VEEV titers were determined at 8 h PI at an
Dal Young Kim (732823), Ivan Akhrymuk (2934816), Elena I. Frolova (732826), Josephine M. Reynaud (732822), Ilya Frolov (211903), Aliaksandra Rasalouskaya (732825), James A. Mobley (365303)   +6 more
core   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

SFV nsP3, containing two FGDF repeats, binds two G3BP molecules, while USP10 binds only one.

, 2015
(A) Schematic representation of the possible binding of the two FGDF motifs in nsP3-31 (left panel) to two G3BP molecules. The right panel shows the possible binding of one G3BP molecule to one FGDF domain of USP101–40.
Tatiana Sandalova (690366), Adnane Achour (113247), Tim Schulte (690365), Nancy Kedersha (690367), Marc D. Panas (690364), Bastian Thaa (418825), Gerald M. McInerney (250016)   +6 more
core   +1 more source

Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells. [PDF]

PLoS ONE, 2017
Stress Granules (SGs) are dynamic ribonucleoprotein aggregates, which have been observed in cells subjected to environmental stresses, such as oxidative stress and heat shock (HS).
Freshteh Palangi, Samson M Samuel, I Richard Thompson, Chris R Triggle, Mohamed M Emara   +4 more
doaj   +1 more source