Results 81 to 90 of about 4,644 (183)

Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus

Parasites & Vectors, 2015
Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros, Corinne Geertsema, Karima Zouache, Jim Baggen, Natalia Domeradzka, Daniël M. van Leeuwen, Jacky Flipse, Just M. Vlak, Anna-Bella Failloux, Gorben P. Pijlman   +9 more
doaj   +1 more source

New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes.

PLoS Pathogens, 2016
The positive-strand RNA viruses initiate their amplification in the cell from a single genome delivered by virion. This single RNA molecule needs to become involved in replication process before it is recognized and degraded by cellular machinery.
Dal Young Kim, Josephine M Reynaud, Aliaksandra Rasalouskaya, Ivan Akhrymuk, James A Mobley, Ilya Frolov, Elena I Frolova   +6 more
doaj   +1 more source

Rasputin functions as a positive regulator of orb in Drosophila oogenesis. [PDF]

PLoS ONE, 2013
The determination of cell fate and the establishment of polarity axes during Drosophila oogenesis depend upon pathways that localize mRNAs within the egg chamber and control their on-site translation. One factor that plays a central role in regulating on-
Alexandre Costa, Cecilia Pazman, Kristina S Sinsimer, Li Chin Wong, Ian McLeod, John Yates, Susan Haynes, Paul Schedl   +7 more
doaj   +1 more source

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis

MedComm, Volume 6, Issue 11, November 2025.
During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial complex I subunits (Ndufa12), leading to suppressed cap‐dependent translation, reduced mitochondrial activity, and impaired innate immune responses.
Jaewhan Kim, Sang‐Hun Son, Ji‐Ae Choi, Junghwan Lee, Seoyeon Jo, Soo‐Na Cho, Doan Tam Nguyen, Doyi Son, Kee K. Kim, Chang‐Hwa Song   +9 more
wiley   +1 more source

The deacetylase HDAC6 is an essential component of stress granules and plays a critical role in the cellular response to stress [PDF]

, 2007
The reversible acetylation of histones has a critical role in transcriptional regulation. Likewise reversible acetylation of non-histones proteins is also important for other cellular processes.
Kwon, So Hee
core   +1 more source

Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay   +4 more
wiley   +1 more source

G3BP-binding enhances translation initiation in SFV-infected cells.

, 2019
A. BHK-21 cells were infected with SFV WT or SFV F3ANC at MOI 10. At 8 hpi cells were treated with cycloheximide and lysates analysed on 5%–50% sucrose gradients. Absorbance at 254 nm is shown as a function of sedimentation and fractions representing 40S,
Kirsi Hellström (399912), Lifeng Liu (164546), Marc D. Panas (690364), Ola Larsson (15776), Benjamin Götte (6843608), Tero Ahola (191447), Baila Samreen (6843611), Gerald M. McInerney (250016)   +7 more
core   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Revisiting G3BP-S149 phosphorylation and its impact on stress granule assembly [PDF]

, 2019
Abstract Stress granules (SGs) are cytoplasmic, non-membranous RNA/protein structures that assemble in response to environmental stress. G3BP is a critical SG-nucleating protein, and its ability to regulate SGs has been reported to be regulated by serine 149 phosphorylation.
Panas, Marc D., Kedersha, Nancy, Schulte, Tim, Branca, Rui M., Ivanov, Pavel, Anderson, Paul   +5 more
openaire   +1 more source

Cancer Cell‐Secreted miR‐33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Tumour progression depends on the bidirectional interactions between cancer and stroma in the heterogeneous tumour microenvironment (TME) partially through extracellular vesicles (EVs). However, the secretary mechanism and biological effect of cancer cell derived EVs on tumour survival under starvation is poorly defined.
Sheng Hu, Xu Li, Qixin Hu, Chenyu Wang, Ao Hua, Gang Deng, Wenda Huang, Xiaoyu Fu, Haifeng Zhou, Xiaohui Zhang, Meixin Li, Juan Wu, Mingzhou Chen, Xiaolu Zhao, Lianyun Li, Zifu Li, Min Wu, Juanjuan Li, Wei Yan   +18 more
wiley   +1 more source