Results 81 to 90 of about 152 (124)

The G3BP stress-granule proteins reinforce the integrated-stress-response translation program

Nature Cell Biology
ABSTRACT When mammalian cells are exposed to stress, they coordinate the condensation of stress granules (SGs) through the action of proteins G3BP1 and G3BP2 (G3BPs) and, simultaneously, undergo a massive reduction in translation. Although SGs and G3BPs have been linked to this translation response, their overall impact has been unclear.
Jarrett Smith, David P. Bartel
openaire   +3 more sources

Foot-and-Mouth Disease Virus Counteracts on Internal Ribosome Entry Site Suppression by G3BP1 and Inhibits G3BP1-Mediated Stress Granule Assembly via Post-Translational Mechanisms

Frontiers in Immunology, 2018
Foot-and-mouth disease (FMD) is a highly contagious, severe viral illness notifiable to the World Organization for Animal Health. The causative agent, FMD virus (FMDV), replicates rapidly and efficiently inhibits host translation and the innate immune ...
Xu Ye, Xu Ye, Ting Pan, Ting Pan, Dang Wang, Dang Wang, Liurong Fang, Liurong Fang, Jun Ma, Jun Ma, Xinyu Zhu, Xinyu Zhu, Yanling Shi, Yanling Shi, Keshan Zhang, Haixue Zheng, Huanchun Chen, Huanchun Chen, Kui Li, Shaobo Xiao, Shaobo Xiao   +20 more
doaj   +1 more source

Pseudorabies virus IE180 protein hijacks G3BPs into the nucleus to inhibit stress granule formation

Journal of Virology
Pseudorabies virus (PRV) is a porcine alphaherpesvirus that can infect different animal species and cause pruritus and lethal encephalitis. Stress granules (SGs) are membrane-free cytoplasmic structures formed by liquid-liquid phase separation of G3BP ...
Ruihan Zhao, Zhenbang Zhu, Wenqiang Wang, Wei Wen, Zhendong Zhang, Herman W. Favoreel, Xiangdong Li   +6 more
doaj   +1 more source

Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules

Viruses, 2015
We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection.
Jonathan D. Dougherty, Wei-Chih Tsai, Richard E. Lloyd   +2 more
doaj   +1 more source

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

Cell Reports
Summary: G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibits stress ...
Zemin Yang, Bryan A. Johnson, Victoria A. Meliopoulos, Xiaohui Ju, Peipei Zhang, Michael P. Hughes, Jinjun Wu, Kaitlin P. Koreski, Jemma E. Clary, Ti-Cheng Chang, Gang Wu, Jeff Hixon, Jay Duffner, Kathy Wong, Rene Lemieux, Kumari G. Lokugamage, R. Elias Alvarado, Patricia A. Crocquet-Valdes, David H. Walker, Kenneth S. Plante, Jessica A. Plante, Scott C. Weaver, Hong Joo Kim, Rachel Meyers, Stacey Schultz-Cherry, Qiang Ding, Vineet D. Menachery, J. Paul Taylor   +27 more
doaj   +1 more source

Research Progress on the Biological Function, Disease-Driving Mechanism and Clinical Targeting Strategies of G3BP2

Molecules
G3BP2 is an important RNA-binding protein that belongs to the mammalian Ras-GAP SH3 domain-binding protein (G3BP) family. Its structure enables it to bind to RNA or proteins, regulate nuclear–cytoplasmic shuttling, and participate in various functions ...
Yao Chen, Qi Deng, Li-Ling Yang, Ai-Ling Jiang, Rong Zhang, Qi-Bing Yan, Yong-Kang Wu   +6 more
doaj   +1 more source

Stress-specific 14-3-3–client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance

Cancer Biology & Therapy
14-3-3 proteins are phosphoserine- and phosphothreonine-binding adaptors that regulate client localization, stability and activity under cellular stress.
Rudong Li, Zhipeng Zhao, Xudong Wang
doaj   +1 more source

Identification of metastasis associated gene G3BP by differential display in human cancer cell sublines with different metastatic potentials G3BP as highly expressed in non-metastatic.

Chinese medical journal, 2002
To investigate genes involved in cancer metastasis, mRNA differential display was used to compare the levels of gene expression in two cell sublines derived from human giant cell carcinoma of lung (PG) which had different metastatic potentials.Using in vivo tumorigenicity and a spontaneous metastasis assay in nude mice, two sublines (BE1, LH7) from ...
Y, Liu, J, Zheng, W, Fang, J, You, J, Wang, X, Cui, B, Wu   +6 more
openaire   +1 more source

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Nature Communications
Considerable progress has been made in understanding the molecular host-virus battlefield during SARS-CoV-2 infection. Nevertheless, the assembly and egress of newly formed virions are less understood.
Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun   +13 more
doaj   +1 more source

USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling

Oncogenesis
Lacking effective therapeutic targets heavily restricts the improvement of clinical prognosis for patients diagnosed with esophageal squamous cell carcinoma (ESCC).
Jiazhong Guo, Yunpeng Zhao, Huacong Sui, Lei Liu, Fanrong Liu, Lingxiao Yang, Fengyuan Gao, Jinfu Wang, Yilin Zhu, Lingbing Li, Xiangqing Song, Peng Li, Zhongxian Tian, Peichao Li, Xiaogang Zhao   +14 more
doaj   +1 more source