Results 91 to 100 of about 5,954 (200)

Rasputin functions as a positive regulator of orb in Drosophila oogenesis. [PDF]

PLoS ONE, 2013
The determination of cell fate and the establishment of polarity axes during Drosophila oogenesis depend upon pathways that localize mRNAs within the egg chamber and control their on-site translation. One factor that plays a central role in regulating on-
Alexandre Costa, Cecilia Pazman, Kristina S Sinsimer, Li Chin Wong, Ian McLeod, John Yates, Susan Haynes, Paul Schedl   +7 more
doaj   +1 more source

Drug-induced stress granule formation protects sensory hair cells in mouse cochlear explants during ototoxicity [PDF]

, 2019
Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation caused by mutation or ageing is associated with neurodegenerative disease.
Dawson, Sally J., Gale, Jonathan E., Gonçalves, Ana Cláudia, Haq, Naila, Pelletier, Jerry, Porco, John A., Towers, Emily R.   +6 more
core   +2 more sources

Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay   +4 more
wiley   +1 more source

Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection [PDF]

, 2015
The mosquito-transmitted bunyavirus, Rift Valley fever virus (RVFV), is a highly successful pathogen for which there are no vaccines or therapeutics. Translational arrest is a common antiviral strategy used by hosts.
Cherry, S., Hackett, B. A., Herrmann, C., Hopkins, K. C., Menghani, S. V., Panda, D., Sabin, L. R., Tartell, M. A., Taschuk, F.   +8 more
core   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

Enhanced stress tolerance through reduction of G3BP and suppression of stress granules [PDF]

, 2020
SUMMARYStress granules (SG) are membrane-less ribonucleoprotein condensates that form in response to various stress stimuli via phase separation. SG act as a protective mechanism to cope with acute stress, but persistent SG have cytotoxic effects that are associated with several age-related diseases.
Lee, Anna K., Klein, Jonathon, Tacer, Klementina Fon, Lord, Tessa, Oatley, Melissa J., Oatley, Jon M., Porter, Shaina N., Pruett-Miller, Shondra M., Tikhonova, Elena B., Karamyshev, Andrey L., Yang, Peiguo, Kim, Hong Joo, Taylor, J. Paul, Potts, Patrick Ryan   +13 more
openaire   +1 more source

SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin. [PDF]

, 2011
International audienceHP1 enrichment at pericentric heterochromatin is considered important for centromere function. Although HP1 binding to H3K9me3 can explain its accumulation at pericentric heterochromatin, how it is initially targeted there remains ...
Almouzni, Geneviève, Bailly, Delphine, Dingli, Florent, Loew, Damarys, Lombard, Bérengère, Maison, Christèle, Montes de Oca, Rocio, Probst, Aline V, Quivy, Jean-Pierre, Roche, Danièle, Vassias, Isabelle   +10 more
core   +3 more sources

Cancer Cell‐Secreted miR‐33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Tumour progression depends on the bidirectional interactions between cancer and stroma in the heterogeneous tumour microenvironment (TME) partially through extracellular vesicles (EVs). However, the secretary mechanism and biological effect of cancer cell derived EVs on tumour survival under starvation is poorly defined.
Sheng Hu, Xu Li, Qixin Hu, Chenyu Wang, Ao Hua, Gang Deng, Wenda Huang, Xiaoyu Fu, Haifeng Zhou, Xiaohui Zhang, Meixin Li, Juan Wu, Mingzhou Chen, Xiaolu Zhao, Lianyun Li, Zifu Li, Min Wu, Juanjuan Li, Wei Yan   +18 more
wiley   +1 more source

Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes [PDF]

, 2006
Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light.
Millard, Stephen A., Wood, Susan M.
core   +2 more sources

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, Volume 15, Issue 7, Page 1054-1067, July 2025.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source