Results 91 to 100 of about 152 (124)

Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression

Molecular Biomedicine
Castration-resistant prostate cancer (CRPC) poses a significant clinical challenge, characterized by limited therapeutic options and unfavorable prognosis, particularly among elderly men.
Haoran Wen, Maierhaba Maheremu, Kaidi Zhang, Liuru Bao, Mayao Luo, Yifan Zhang, Yuanpeng Liao, Manli Zhou, Chenwei Wu, Shidong Lv, Xiaofu Qiu, Qiang Wei   +11 more
doaj   +1 more source

Retract and Replace: The RasGAP-associated endoribonuclease G3BP assembles stress granules

Journal of Cell Biology, 2023
Tourrière, Hélène, Chebli, Karim, Zekri, Latifa, Courselaud, Brice, Blanchard, Jean Marie, Bertrand, Edouard, Tazi, Jamal   +6 more
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Alphavirus-host interactions : how to unravel the proviral activity of G3BP

, 2019
The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically distinguished into Old World and New World alphaviruses.
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Role(s) of G3BPs in Human Pathogenesis

The Journal of Pharmacology and Experimental Therapeutics, 2023
Ras-GTPase-activating protein (SH3 domain)-binding proteins (G3BP) are RNA binding proteins that play a critical role in stress granule (SG) formation. SGs protect critical mRNAs from various environmental stress conditions by regulating mRNA stability and translation to maintain regulated gene expression.
Chandrani Mukhopadhyay, Pengbo Zhou
openaire   +2 more sources

The expression and function of G3BPs in macrophages [PDF]

, 2023
Macrophages are highly inducible and extremely potent cells of the innate immune system. Macrophage activation by invading pathogens initiates signalling cascades and a gene expression programme that can have dire consequences for the host if left unchecked.
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Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules

Cell, 2023
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecular links remain elusive.
Qinqin, Cui, Hongyun, Bi, Zhanyun, Lv, Qigui, Wu, Jianfeng, Hua, Bokai, Gu, Chanjuan, Huo, Mingmin, Tang, Yanqin, Chen, Chongjiu, Chen, Sihan, Chen, Xinrui, Zhang, Zhangrui, Wu, Zhengkai, Lao, Nengyin, Sheng, Chengyong, Shen, Yongdeng, Zhang, Zhi-Ying, Wu, Zhigang, Jin, Peiguo, Yang, Huaqing, Liu, Jinsong, Li, Ge, Bai   +22 more
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Arabidopsis thaliana G3BP Ortholog Rescues Mammalian Stress Granule Phenotype across Kingdoms

International Journal of Molecular Sciences, 2021
Stress granules (SGs) are dynamic RNA–protein complexes localized in the cytoplasm that rapidly form under stress conditions and disperse when normal conditions are restored. The formation of SGs depends on the Ras-GAP SH3 domain-binding protein (G3BP).
Timothy Jc Tan, Marc Panas, Gerald Mcinerney   +2 more
exaly   +3 more sources

G3BP is overexpressed in human tumors and promotes S phase entry.

Cancer Letters, 2001
The expression of the human Ras-GTPase activating protein (GAP)-binding protein (G3BP) was studied in human tumors and cell lines of different origins. Northern blot analysis and immunoblotting experiments showed enhanced expression of G3BP in all tumor samples as compared to healthy tissue.
Bruno Tocque, B Tocque, F Parker
exaly   +3 more sources

Tudor‐SN interacts with and co‐localizes with G3BP in stress granules under stress conditions [PDF]

FEBS Letters, 2010
MINT‐7968768, MINT‐7968779: Tudor‐SN (uniprotkb:Q7KZF4) physically interacts (MI:0915) with G3BP (uniprotkb:Q13283) by anti bait coimmunoprecipitation (MI:0006) MINT‐7968800: Tudor‐SN (uniprotkb:Q7KZF4) and TIA‐1 (uniprotkb:P31483) colocalize (MI:0403) by fluorescence microscopy (MI:0416) MINT‐7968789: Tudor‐SN (uniprotkb:Q7KZF4) and G3BP (uniprotkb ...
Xingjie Gao, Jie Yang, Jie Shao
exaly   +3 more sources

Structure-Based Design of Peptides against G3BP with Cytotoxicity on Tumor Cells

Journal of Chemical Information and Modeling, 2010
Herein, we report a successful application of molecular modeling techniques to design two novel peptides with cytotoxicity on tumor cells. First, the interactions between the nuclear transport factor 2 (NTF2)-like domain of G3BP and the SH3 domain of RasGAP were studied by a well-designed protocol, which combines homology modeling, protein/protein ...
Wei Cui, Zhuo Wei, Quan Chen, Yuanhua Cheng, Lingling Geng, Jian Zhang 0037, Jianhua Chen, Tingjun Hou, Mingjuan Ji   +8 more
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