Results 101 to 110 of about 4,644 (183)

Rasputin/G3BP mediates o’nyong-nyong virus subversion of antiviral immunity in Anopheles coluzzii

, 2022
Posted November 23, 2022 on bioRxiv.The G3BP proteins in vertebrates and Aedes mosquito ortholog, Rasputin, are essential for alphavirus infection, but the underlying mechanism of Rasputin/G3BP proviral activity is poorly understood.
Failloux, Anna-Bella, Blisnick, Adrien, Brito-Fravallo, Emma, Mitri, Christian, Matondo, Mariette, Vernick, Kenneth, D., Cottis, Solène   +6 more
core   +1 more source

Foot-and-Mouth Disease Virus Counteracts on Internal Ribosome Entry Site Suppression by G3BP1 and Inhibits G3BP1-Mediated Stress Granule Assembly via Post-Translational Mechanisms

Frontiers in Immunology, 2018
Foot-and-mouth disease (FMD) is a highly contagious, severe viral illness notifiable to the World Organization for Animal Health. The causative agent, FMD virus (FMDV), replicates rapidly and efficiently inhibits host translation and the innate immune ...
Xu Ye, Xu Ye, Ting Pan, Ting Pan, Dang Wang, Dang Wang, Liurong Fang, Liurong Fang, Jun Ma, Jun Ma, Xinyu Zhu, Xinyu Zhu, Yanling Shi, Yanling Shi, Keshan Zhang, Haixue Zheng, Huanchun Chen, Huanchun Chen, Kui Li, Shaobo Xiao, Shaobo Xiao   +20 more
doaj   +1 more source

Multiple Poliovirus Proteins Repress Cytoplasmic RNA Granules

Viruses, 2015
We have previously shown that poliovirus (PV) infection induces stress granule (SG) formation early in infection and then inhibits the formation of SG and disperses processing bodies (PBs) by the mid-phase of infection.
Jonathan D. Dougherty, Wei-Chih Tsai, Richard E. Lloyd   +2 more
doaj   +1 more source

The knockout of Fxr or G3bp genes differentially affects replication of alphaviruses.

, 2016
(A) Left panels: growth curves of the indicated alphaviruses in NIH 3T3, Fxr dKO and Fxr tKO cells (MOI 1). Right panels: bar graphs show titers of the indicated viruses in NIH 3T3 and Fxr tKO cells at 8 h PI (MOI 0.05, three biological repeats).
Dal Young Kim (732823), Ivan Akhrymuk (2934816), Elena I. Frolova (732826), Josephine M. Reynaud (732822), Ilya Frolov (211903), Aliaksandra Rasalouskaya (732825), James A. Mobley (365303)   +6 more
core   +1 more source

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

Cell Reports
Summary: G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibits stress ...
Zemin Yang, Bryan A. Johnson, Victoria A. Meliopoulos, Xiaohui Ju, Peipei Zhang, Michael P. Hughes, Jinjun Wu, Kaitlin P. Koreski, Jemma E. Clary, Ti-Cheng Chang, Gang Wu, Jeff Hixon, Jay Duffner, Kathy Wong, Rene Lemieux, Kumari G. Lokugamage, R. Elias Alvarado, Patricia A. Crocquet-Valdes, David H. Walker, Kenneth S. Plante, Jessica A. Plante, Scott C. Weaver, Hong Joo Kim, Rachel Meyers, Stacey Schultz-Cherry, Qiang Ding, Vineet D. Menachery, J. Paul Taylor   +27 more
doaj   +1 more source

Identification of metastasis associated gene G3BP by differential display in human cancer cell sublines with different metastatic potentials G3BP as highly expressed in non-metastatic.

Chinese medical journal, 2002
To investigate genes involved in cancer metastasis, mRNA differential display was used to compare the levels of gene expression in two cell sublines derived from human giant cell carcinoma of lung (PG) which had different metastatic potentials.Using in vivo tumorigenicity and a spontaneous metastasis assay in nude mice, two sublines (BE1, LH7) from ...
Y, Liu, J, Zheng, W, Fang, J, You, J, Wang, X, Cui, B, Wu   +6 more
openaire   +1 more source

Endogenous TDP-43 participates in arsenite-induced G3BP positive stress granules.

, 2012
(A) Endogenous TDP-43 (green) stained with an N-terminal monoclonal antibody raised against residues 1–260, and G3BP (red) in control and sodium arsenite (0.5 mM, 45 min)-treated HEK-293 cells. (B) A small fraction of endogenous TDP-43 (red) localizes to
Wilfried Rossoll (156831), Nicholas T. Seyfried (156851), Claudia Fallini (59162), James J. Lah (142808), Allan I. Levey (142805), Duc M. Duong (156825), Gary J. Bassell (156845), Yair M. Gozal (156818), Ping Xu (122619), Junmin Peng (156839), Eric B. Dammer (156812)   +10 more
core   +1 more source

SFV-F3A does not sequester G3BP, induces a stronger SG response and is attenuated in vitro.

, 2015
(A) BHK cells were infected at MOI 10 with SFV-wt or SFV-F3A. At 8 hpi, cell lysates were prepared and immunoprecipitated with G3BP-1 antisera and separated by SDS–PAGE. Lysates and IPs were probed for nsP3, G3BP-1 or actin.
Tatiana Sandalova (690366), Adnane Achour (113247), Tim Schulte (690365), Nancy Kedersha (690367), Marc D. Panas (690364), Bastian Thaa (418825), Gerald M. McInerney (250016)   +6 more
core   +1 more source

Mutagenesis of the G3BP-binding domain in SFV-nsP3 reveals a core binding motif of FGDF.

, 2015
(A) C-terminal sequences of pEGFP-C1, pEGFP-nsP3-31-wt, -T2A, -F3A, -G4A, -D5A, -F6A or -D7A. Alanine mutations are shown in bold. (B) BHK cells were mock transfected (M) or transfected with pEGFP-nsP3-31-wt, -T2A, -F3A, -G4A, -D5A, -F6A or -D7A or pEGFP-
Tatiana Sandalova (690366), Adnane Achour (113247), Tim Schulte (690365), Nancy Kedersha (690367), Marc D. Panas (690364), Bastian Thaa (418825), Gerald M. McInerney (250016)   +6 more
core   +1 more source

Differential effects of G3BP isoforms on stress granule assembly and gene expression during cellular stress [PDF]

Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these condensates is driven by the condensation of RNA and RNA-binding proteins such as G3BPs.
Liboy Lugo, Jose
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