Results 101 to 110 of about 152 (124)

Abstract 1246: Role of PKCα and G3BP in stress granule formation

Cancer Research, 2011
Abstract Cells exposed to environmental stress protect themselves from damage by regulation of protein synthesis. Translation of certain proteins is being inhibited at mRNA level in order to influence repair mechanisms. The untranslated mRNAs are assembled into cytoplasmic complexes known as stress granules and will be stalled in this ...
Sofia Winslow, Tamae Kobayashi, Lovisa Sunesson, Christer Larsson   +3 more
openaire   +1 more source

[G3BP: a promising target for cancer therapy].

Yao xue xue bao = Acta pharmaceutica Sinica, 2012
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation.
Hao, Zhang, Rong-guang, Shao
openaire   +1 more source

Reduced mRNA for G3BP in fragile X cells: Evidence of FMR1 gene regulation

American Journal of Medical Genetics, 1999
Although fragile X syndrome is caused by the absence of fragile X gene expression, little is known about the pathogenic processes underlying the mental retardation. Recent findings that the fragile X protein, FMRP, contains RNA binding motifs and nuclear transport signals and associates with ribosomes suggest that FMRP may be involved in either mRNA ...
N, Zhong, W, Ju, D, Nelson, C, Dobkin, W T, Brown   +4 more
openaire   +2 more sources

Intracellular CD24 Inhibits Cell Invasion by Posttranscriptional Regulation of BART through Interaction with G3BP

Cancer Research, 2011
Abstract We report a novel function for the CD24 molecule in pancreatic cancer cells. Intracellular CD24 is associated with stress granules that contain specific mRNAs and RNA-binding proteins that regulate mRNA stability and translation.
Keisuke, Taniuchi, Isao, Nishimori, Michael A, Hollingsworth   +2 more
openaire   +2 more sources

Characterisation of the G3BP family of proteins

Human ras-GAP120 SH3 domain-binding protein (G3BP) was first identified by its co-immunoprecipitation with rasGAP120, a key regulatory molecule in the ras signalling pathway. Around the same time, a second gene with high homology to G3BP was identified during a general screen for RNA-binding proteins.
openaire   +2 more sources

Nuclear Localization of G3BP6 Is Essential for the Flowering Transition in Arabidopsis

Biomolecules, 2023
Jiansheng Liang, Yeling Zhou, Li Zhiyong   +2 more
exaly  

Localized G3BP aggregation in axonal regeneration

2015
Pabitra Kumar Sahoo, A. Sharaf, C. Gomes, S.J. Lee, S.M. Randolph, R.B. Perry, M. Fainzilber, J.L. Twiss   +7 more
openaire   +1 more source

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Cell, 2020
Julia Mahamid, Sina Wittmann, Andrii Kopach   +2 more
exaly  

In silico identification of MicroRNAs targeting the key nucleator of stress granules, G3BP: Promising therapeutics for SARS-CoV-2 infection

Saudi Journal of Biological Sciences, 2021
Nemat Ali, Md Khalid Anwer, Bjad Almutairy   +2 more
exaly  

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance

Molecular Cell, 2020
Jon Oatley, Yong-Dong Wang, Andrey Karamyshev   +2 more
exaly