Results 11 to 20 of about 152 (124)

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP [PDF]

Molecular Neurodegeneration, 2012
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, a cell type that is intrinsically more vulnerable than other cell types to exogenous stress.
Aulas Anaïs, Stabile Stéphanie, Vande Velde Christine   +2 more
doaj   +3 more sources

G3BPs in Plant Stress [PDF]

Frontiers in Plant Science, 2021
The sessile nature of plants enforces highly adaptable strategies to adapt to different environmental stresses. Plants respond to these stresses by a massive reprogramming of mRNA metabolism. Balancing of mRNA fates, including translation, sequestration, and decay is essential for plants to not only coordinate growth and development but also to combat ...
Aala A. Abulfaraj, Heribert Hirt, Heribert Hirt, Naganand Rayapuram   +3 more
openaire   +4 more sources

The miR‐669a‐5p/G3BP/HDAC6/AKAP12 Axis Regulates Primary Cilia Length

Advanced Science, 2023
Primary cilia are conserved organelles in most mammalian cells, acting as “antennae” to sense external signals. Maintaining a physiological cilium length is required for cilium function.
Weina Wang, Xuyao Dai, Yue Li, Mo Li, Zongqi Chi, Xiaoyu Hu, Zhenshan Wang   +6 more
doaj   +3 more sources

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling [PDF]

Cell, 2021
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (TSC) protein complex to lysosomes and suppress ...
Prentzell, M., Rehbein, U., Cadena Sandoval, M., De Meulemeester, A., Baumeister, R., Brohée, L., Berdel, B., Bockwoldt, M., Carroll, B., Chowdhury, S., von Deimling, A., Demetriades, C., Figlia, G., Genomics England Research, C., de Araujo, M., Heberle, A., Heiland, I., Holzwarth, B., Huber, L., Jaworski, J., Kedra, M., Kern, K., Kopach, A., Korolchuk, V., van 't Land-Kuper, I., Macias, M., Nellist, M., Palm, W., Pusch, S., Ramos Pittol, J., Reil, M., Reintjes, A., Reuter, F., Sampson, J., Scheldeman, C., Siekierska, A., Stefan, E., Teleman, A., Thomas, L., Torres-Quesada, O., Trump, S., West, H., de Witte, P., Woltering, S., Yordanov, T., Zmorzynska, J., Opitz, C., Thedieck, K.   +47 more
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The RasGAP-associated endoribonuclease G3BP assembles stress granules. [PDF]

The Journal of cell biology, 2003
Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents, and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are stored in an abortive translation initiation complex that can be routed to either translation initiation or degradation.
Tourrière, Hélène, Chebli, Karim, Zekri, Latifa, Courselaud, Brice, Blanchard, Jean Marie, Bertrand, Edouard, Tazi, Jamal   +6 more
openaire   +2 more sources

The RasGAP-associated endoribonuclease G3BP mediates stress granule assembly

Journal of Cell Biology, 2023
Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are stored in an abortive translation initiation complex that can be routed to either translation initiation or degradation.
Hélène Tourrière, Karim Chebli, Latifa Zekri, Brice Courselaud, Jean Marie Blanchard, Edouard Bertrand, Jamal Tazi   +6 more
openaire   +2 more sources

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells [PDF]

Journal of Visualized Experiments, 2014
SGs can be visualized in cells by immunostaining of specific protein components or polyA+ mRNAs. SGs are highly dynamic and the study of their assembly and fate is important to understand the cellular response to stress. The deficiency in key factors of SGs like G3BP (RasGAP SH3 domain Binding Protein) leads to developmental defects in mice and ...
Martin, S., Chebli, K., Tazi, J.
openaire   +3 more sources

Identification of small molecule inhibitors of G3BP-driven stress granule formation

Journal of Cell Biology, 2023
ABSTRACT Stress granule formation is triggered by the release of mRNAs from polysomes and is promoted by the action of the paralogs G3BP1 and G3BP2. G3BP1/2 proteins bind mRNAs and thereby promote the condensation of mRNPs into stress granules.
Brian D. Freibaum, James Messing, Haruko Nakamura, Ugur Yurtsever, Jinjun Wu, Hong Joo Kim, Jeff Hixon, Rene Marc Lemieux, Jay Duffner, Walter Huynh, Kathy Wong, Michael White, Christina Lee, Rachel E. Meyers, Roy Parker, J. Paul Taylor   +15 more
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Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis [PDF]

World Journal of Gastroenterology, 2007
To investigate the expression and significance of G3BP and RhoC proteins in esophageal squamous carcinoma (ESC).The expression of G3BP and Rhoc proteins in 80 cases of ESC was detected by immunohistochemistry. The relationship was studied between the expression of the two proteins and tumor size, differentiation degree, TNM stage, lymph node metastasis
Hui-Zhong, Zhang, Jin-Geng, Liu, Yi-Ping, Wei, Cheng, Wu, Yong-Ke, Cao, Mei, Wang   +5 more
openaire   +2 more sources

Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formation.

PLoS Pathogens, 2015
The Ras-GAP SH3 domain-binding proteins (G3BP) are essential regulators of the formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced upon cellular stress, such as virus infection.
Marc D Panas, Tim Schulte, Bastian Thaa, Tatiana Sandalova, Nancy Kedersha, Adnane Achour, Gerald M McInerney   +6 more
doaj   +1 more source