Results 11 to 20 of about 5,954 (200)

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP [PDF]

Molecular Neurodegeneration, 2012
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, a cell type that is intrinsically more vulnerable than other cell types to exogenous stress.
Anaïs Aulas, Christine Vande Velde
exaly   +5 more sources

The miR‐669a‐5p/G3BP/HDAC6/AKAP12 Axis Regulates Primary Cilia Length [PDF]

Advanced Science, 2023
Primary cilia are conserved organelles in most mammalian cells, acting as “antennae” to sense external signals. Maintaining a physiological cilium length is required for cilium function.
Weina Wang, Xuyao Dai, Yue Li, Mo Li, Zongqi Chi, Xiaoyu Hu, Zhenshan Wang   +6 more
doaj   +4 more sources

Comprehensive evolutionary analysis and nomenclature of plant G3BPs

Life Science Alliance, 2022
A thorough phylogenetic analysis of eukaryotic G3BPs (Rasputins) with a focus on plant G3BP proteins, classification into two subfamilies and a proposed systematic nomenclature.
Aala A Abulfaraj, Hajime Ohyanagi, Kosuke Goto, Katsuhiko Mineta, Takashi Gojobori, Heribert Hirt, Naganand Rayapuram   +6 more
doaj   +4 more sources

The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [PDF]

Journal of Virology
Stress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay.
Ayisha A. Lavender, Oreoluwa Solanke, Hsin-Yao Tang, Hannah E. Peck, Daryll Vanover, Philip J. Santangelo, Margo A. Brinton   +6 more
doaj   +2 more sources

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models [PDF]

Advanced Science
Stress granules (SGs) fulfill a pivotal role in host defense mechanisms, by sequestering both mRNA and protein via the process of liquid–liquid phase separation (LLPS).
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
doaj   +2 more sources

G3BPs in Plant Stress [PDF]

Frontiers in Plant Science, 2021
The sessile nature of plants enforces highly adaptable strategies to adapt to different environmental stresses. Plants respond to these stresses by a massive reprogramming of mRNA metabolism. Balancing of mRNA fates, including translation, sequestration, and decay is essential for plants to not only coordinate growth and development but also to combat ...
Aala A. Abulfaraj, Heribert Hirt, Heribert Hirt, Naganand Rayapuram   +3 more
openaire   +4 more sources

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling [PDF]

Cell, 2021
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (TSC) protein complex to lysosomes and suppress ...
Prentzell, Mirja Tamara, Rehbein, Ulrike, Sandoval, Marti Cadena, De Meulemeester, Ann-Sofie, Baumeister, Ralf, Brohee, Laura, Berdel, Bianca, Bockwoldt, Mathias, Carroll, Bernadette, Chowdhury, Suvagata Roy, von Deimling, Andreas, Demetriades, Constantinos, Figlia, Gianluca, de Araujo, Mariana Eca Guimaraes, Heberle, Alexander M., Heiland, Ines, Holzwarth, Birgit, Huber, Lukas A., Jaworski, Jacek, Kedra, Magdalena, Kern, Katharina, Kopach, Andrii, Korolchuk, Viktor, van't Land-Kuper, Ineke, Macias, Matylda, Nellist, Mark, Palm, Wilhelm, Pusch, Stefan, Pittol, Jose Miguel Ramos, Reil, Michele, Reintjes, Anja, Reuter, Friederike, Sampson, Julian R., Scheldeman, Chloe, Siekierska, Aleksandra, Stefan, Eduard, Teleman, Aurelio A., Thomas, Laura E., Torres-Quesada, Omar, Trump, Saskia, West, Hannah D., de Witte, Peter, Woltering, Sandra, Yordanov, Teodor E., Zmorzynska, Justyna, Opitz, Christiane A., Thedieck, Kathrin   +46 more
openaire   +9 more sources

The RasGAP-associated endoribonuclease G3BP assembles stress granules. [PDF]

The Journal of cell biology, 2003
Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents, and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are stored in an abortive translation initiation complex that can be routed to either translation initiation or degradation.
Tourrière, Hélène, Chebli, Karim, Zekri, Latifa, Courselaud, Brice, Blanchard, Jean Marie, Bertrand, Edouard, Tazi, Jamal   +6 more
openaire   +2 more sources

The RasGAP-associated endoribonuclease G3BP mediates stress granule assembly

Journal of Cell Biology, 2023
Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are stored in an abortive translation initiation complex that can be routed to either translation initiation or degradation.
Hélène Tourrière, Karim Chebli, Latifa Zekri, Brice Courselaud, Jean Marie Blanchard, Edouard Bertrand, Jamal Tazi   +6 more
openaire   +2 more sources

Phase separation of a plant virus movement protein and cellular factors support virus-host interactions.

PLoS Pathogens, 2021
Both cellular and viral proteins can undergo phase separation and form membraneless compartments that concentrate biomolecules. The p26 movement protein from single-stranded, positive-sense Pea enation mosaic virus 2 (PEMV2) separates into a dense phase ...
Shelby L Brown, Dana J Garrison, Jared P May   +2 more
doaj   +1 more source