Interactions of Alphavirus nsP3 Protein with Host Proteins
Frontiers in Microbiology, 2018 Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Forrest Keck, Aarthi Narayanan
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Species A rotavirus NSP3 acquires its translation inhibitory function prior to stable dimer formation. [PDF]
PLoS ONE, 2017 Species A rotavirus non-structural protein 3 (NSP3) is a translational regulator that inhibits or, under some conditions, enhances host cell translation.
Hugo I Contreras-Treviño +6 more
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SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication. [PDF]
PLoS Pathogens, 2011 Among the four non-structural proteins of alphaviruses the function of nsP3 is the least well understood. NsP3 is a component of the viral replication complex, and composed of a conserved aminoterminal macro domain implicated in viral RNA synthesis, and ...
Maarit Neuvonen +5 more
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Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus [PDF]
Parasites & Vectors, 2015 Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros +9 more
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The transmembrane segments of SARS-CoV-2 nsp3 govern viral intracellular trafficking [PDF]
Cell & BioscienceAfter entry, coronaviruses deliver their genomic RNA to the ER-Golgi intermediate compartment to build replication organelles, yet how the RNA first contacts membranes is unclear.
Manqi Cao +16 more
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mBioChikungunya virus (CHIKV) poses a severe threat to global public health. The interaction between CHIKV nsP3 and host G3BP1 is critical for viral replication. However, the exact structural mechanism of the nsP3–G3BP1 interaction is scarce. Here, we report
Yuanzhi Liu +8 more
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Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus [PDF]
Viruses, 2018 Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Margit Mutso +13 more
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VPS33A and VPS18 orchestrate porcine epidemic diarrhea virus replication by modulating autophagic flux [PDF]
VirulenceCompletion of autophagy through autophagosome-lysosome fusion represents a critical regulatory checkpoint that is frequently manipulated during viral infection, however, how coronaviruses exploit this terminal step remains incompletely understood ...
Liang Guo +7 more
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Correction to "Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication". [PDF]
Adv Sci (Weinh)Advanced Science, Volume 13, Issue 41, 22 July 2026.
europepmc +2 more sources
Heliyon, 2020 Literature reported that nsp3 of CHIKV is an important target for the designing of drug as it involves in the replication, survival etc. Herein, about eighteen million molecules available in the ZINC database are filtered against nsp3 using RASPD.
Prashant Singh +2 more
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