Results 11 to 20 of about 407 (85)

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.

PLoS ONE, 2021
Of the 16 non-structural proteins (Nsps) encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. Being a large, multidomain, transmembrane protein, Nsp3 has been the most challenging Nsp to characterize.
Lee A Armstrong, Sven M Lange, Virginia Dee Cesare, Stephen P Matthews, Raja Sekhar Nirujogi, Isobel Cole, Anthony Hope, Fraser Cunningham, Rachel Toth, Rukmini Mukherjee, Denisa Bojkova, Franz Gruber, David Gray, Paul G Wyatt, Jindrich Cinatl, Ivan Dikic, Paul Davies, Yogesh Kulathu   +17 more
doaj   +1 more source

Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3

Scientific Reports, 2023
Replication of the coronavirus genome starts with the formation of viral RNA-containing double-membrane vesicles (DMV) following viral entry into the host cell.
Yunfeng Li, Yulia Pustovalova, Wuxian Shi, Oksana Gorbatyuk, Sridhar Sreeramulu, Harald Schwalbe, Jeffrey C. Hoch, Bing Hao   +7 more
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Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes

IUCrJ, 2020
Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Lucy Stols, Michael Endres, Andrzej Joachimiak   +6 more
doaj   +1 more source

Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication [PDF]

Open Biology, 2016
Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures formed upon environmental ...
Tim Schulte, Lifeng Liu, Marc D. Panas, Bastian Thaa, Nicole Dickson, Benjamin Götte, Adnane Achour, Gerald M. McInerney   +7 more
doaj   +1 more source

Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity.

PLoS Neglected Tropical Diseases, 2023
Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people.
Nathaniel M Byers, Paul L Burns, Olga Stuchlik, Matthew S Reed, Jeremy P Ledermann, Jan Pohl, Ann M Powers   +6 more
doaj   +1 more source

Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N)

Majalah Obat Tradisional, 2022
Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV.
Roihatul Mutiah, Chamlah Ayatillah, Yen yen Ari Indrawijaya, Arief Suryadinata   +3 more
doaj   +1 more source

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Viruses, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak   +13 more
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Mosquito Rasputin interacts with chikungunya virus nsP3 and determines the infection rate in Aedes albopictus

Parasites & Vectors, 2015
Background Chikungunya virus (CHIKV) is an arthritogenic alphavirus (family Togaviridae), transmitted by Aedes species mosquitoes. CHIKV re-emerged in 2004 with multiple outbreaks worldwide and recently reached the Americas where it has infected over a ...
Jelke J. Fros, Corinne Geertsema, Karima Zouache, Jim Baggen, Natalia Domeradzka, Daniël M. van Leeuwen, Jacky Flipse, Just M. Vlak, Anna-Bella Failloux, Gorben P. Pijlman   +9 more
doaj   +1 more source

A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins

Frontiers in Cell and Developmental Biology, 2021
Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee, Julian W. Bakker, Corinne Geertsema, Vera I. D. Ros, Giel P. Göertz, Jelke J. Fros, Gorben P. Pijlman   +6 more
doaj   +1 more source

Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy

Pharmaceuticals, 2022
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges (NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared.
Md. Khalid Anwer, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Muzaffar Iqbal, Vinay Kumar   +4 more
doaj   +1 more source