Results 11 to 20 of about 14,170 (209)

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors

Pathogens, 2023
The worldwide public health and socioeconomic consequences caused by the COVID-19 pandemic highlight the importance of increasing preparedness for viral disease outbreaks by providing rapid disease prevention and treatment strategies.
Marion Schuller, Stephane De Cesco, Daren Fearon   +2 more
exaly   +6 more sources

Challenging the Roles of NSP3 and Untranslated Regions in Rotavirus mRNA Translation. [PDF]

PLoS ONE, 2016
Rotavirus NSP3 is a translational surrogate of the PABP-poly(A) complex for rotavirus mRNAs. To further explore the effects of NSP3 and untranslated regions (UTRs) on rotavirus mRNAs translation, we used a quantitative in vivo assay with simultaneous ...
Matthieu Gratia, Patrice Vende, Annie Charpilienne, Hilma Carolina Baron, Cécile Laroche, Emeline Sarot, Stéphane Pyronnet, Mariela Duarte, Didier Poncet   +8 more
doaj   +6 more sources

Interactions of Alphavirus nsP3 Protein with Host Proteins [PDF]

Frontiers in Microbiology, 2018
Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark, Forrest Keck, Aarthi Narayanan   +2 more
doaj   +3 more sources

Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

Nature Communications
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Michael T Hons, Juan Reguera, Ali Amara
exaly   +2 more sources

Involvement of PRRSV NSP3 and NSP5 in the autophagy process

Virology Journal, 2019
Background Autophagy is an essential process in eukaryotic cells in which autophagosomes form to deliver cellular organelles and long-lived proteins to lysosomes for degradation. Many studies have recently identified the regulatory mechanisms involved in
Wei Zhang, Keren Chen, Yang Guo, Yaosheng Chen, Xiaohong Liu   +4 more
doaj   +3 more sources

Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles [PDF]

mBio, 2013
Coronaviruses (CoV), like other positive-stranded RNA viruses, redirect and rearrange host cell membranes for use as part of the viral genome replication and transcription machinery.
Megan M. Angelini, Marzieh Akhlaghpour, Benjamin W. Neuman, Michael J. Buchmeier   +3 more
doaj   +2 more sources

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.

PLoS ONE, 2021
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence.
Sixue Zhang, Atefeh Garzan, Nicole Haese, Robert Bostwick, Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Daniel N Streblow, Mark T Haise, Ashish K Pathak, Corinne E Augelli-Szafran, Mousheng Wu   +10 more
doaj   +4 more sources

The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions

EMBO Reports
Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these ...
Rojelio Alvarado, Fabian Coscia, Emma Nilsson   +2 more
exaly   +2 more sources

Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation

Microorganisms, 2023
Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication.
Shangxin Yang, Ashrit Multani, Jacob M. Garrigues, Michael S. Oh, Peera Hemarajata, Taylor Burleson, Nicole M. Green, Caspian Oliai, Pryce T. Gaynor, Omer E. Beaird, Drew J. Winston, Christopher S. Seet, Joanna M. Schaenman   +12 more
doaj   +1 more source

Preparation of polyclonal antibodies and subcellular localization of non-structural protein 3 encoded by feline coronavirus

浙江大学学报. 农业与生命科学版, 2023
The non-structural protein 3 (Nsp3) of coronavirus, a component of the replication and transcription complex, is one of the potentially important antiviral targets.
WANG Ziyi, JIN Zi’an, LU Chenhe, QIAO Zhi, WANG Shengwen, YAN Yan, ZHOU Jiyong, ZHENG Xiaojuan   +7 more
doaj   +1 more source