Results 11 to 20 of about 9,079 (162)

The DMV pore-forming TM2–Y region of SARS-CoV-2 nsp3 exhibits structural conservation beyond the coronavirus family [PDF]

Journal of Virology
Positive-strand RNA viruses remodel host intracellular membranes to form replication organelles in the cytoplasm. SARS-CoV-2 and other coronaviruses, members of the Nidovirales order, replicate within double-membrane vesicles (DMVs) derived from the ...
Alexandra Pozhidaeva, Jeffrey C. Hoch, Yulia Pustovalova   +2 more
doaj   +2 more sources

SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactions [PDF]

Microbiology Spectrum
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), triggered a global pandemic with a significant impact on human health. The molecular basis of its pathogenicity remains incompletely
Hui Yang, Daxin Peng, Luis Martinez-Sobrido, Chengjin Ye   +3 more
doaj   +2 more sources

Involvement of PRRSV NSP3 and NSP5 in the autophagy process

Virology Journal, 2019
Background Autophagy is an essential process in eukaryotic cells in which autophagosomes form to deliver cellular organelles and long-lived proteins to lysosomes for degradation. Many studies have recently identified the regulatory mechanisms involved in
Wei Zhang, Keren Chen, Yang Guo, Yaosheng Chen, Xiaohong Liu   +4 more
doaj   +3 more sources

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research [PDF]

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +2 more sources

Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulation for the Discovery of Novel SARS-CoV-2 NSP3 Mac1 Domain Inhibitors

Viruses, 2023
Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs).
Behnaz Yazdani, Hajar Sirous, Simone Brogi   +2 more
exaly   +3 more sources

Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis Virus

Molecules, 2020
In recent years, intrinsically disordered proteins (IDPs) and disordered domains have attracted great attention. Many of them contain linear motifs that mediate interactions with other factors during formation of multicomponent protein complexes.
Tatiana Agback, Andrey V Shernyukov, FRANCISCO Dominguez   +2 more
exaly   +3 more sources

Structural and functional analyses of SARS-CoV-2 Nsp3 and its specific interactions with the 5’ UTR of the viral genome [PDF]

Microbiology Spectrum
Non-structural protein 3 (Nsp3) is the largest open reading frame encoded in the SARS-CoV-2 genome, essential for the formation of double-membrane vesicles (DMV) wherein viral RNA replication occurs.
Sofia Lemak, Tatiana Skarina, Deepak T. Patel, Peter J. Stogios, Alexei Savchenko   +4 more
doaj   +2 more sources

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription [PDF]

Journal of Virology
Coronavirus replication is understood to occur within double membrane vesicles (DMVs) that arise during viral infection. Prior work has determined that these DMVs have characteristic pores formed from the non-structural viral proteins nsp3 and nsp4 ...
Jason K. Perry, Samuel Itskanov, John P. Bilello, Eric B. Lansdon   +3 more
doaj   +2 more sources

Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

Nature Communications
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L. Thienel, Beate M. Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera   +16 more
doaj   +5 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1 [PDF]

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +2 more sources