Results 81 to 90 of about 12,322 (192)

Ferritinophagy Rewires Carnitine‐Dependent Lipid Metabolism to Inhibit PRRSV and IAV Replication

Advanced Science, Volume 13, Issue 45, 13 August 2026.
NCOA4‐mediated ferritinophagy reprograms carnitine metabolism by disrupting Fe‐S cluster biogenesis, thereby establishing an iron‐lipid axis that suppresses various viruses, including PRRSV and IAV. However, viruses counteract this mechanism by degrading NCOA4.
Kaifeng Guan, Chenyang Yuan, Zekun Meng, Yanan Wang, Xueying Zhai, Chunjie Huang, Xiang Zhou, Gaiping Zhang   +7 more
wiley   +1 more source

CHIKV genome RNA association with nsP3 during virus replication.

, 2019
C2C12 cells were electroporated with ICRES nsP3-TST or untagged ICRES RNAs (wildtype (WT) and P247A/V248A). (A) Supernatants were harvested at 48 h.p.e and titrated by plaque assay on BHK-21 cells. Data are displayed as the means ± S.E.
Yanni Gao (6250973), Joseph Ward (645977), Niluka Goonawardane (4782675), Andrew Tuplin (3163998), Mark Harris (33805)   +4 more
core   +1 more source

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy

Scientific Reports, 2017
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle and joint pain, which can become chronic in some individuals. The non-structural protein 3 (nsP3) plays essential roles during infection, but a complete understanding ...
Roland Remenyi, Grace C. Roberts, Carsten Zothner, Andres Merits, Mark Harris   +4 more
doaj   +1 more source

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Viruses, 2021
Venezuelan equine encephalitis virus (VEEV) is a new world alphavirus and a category B select agent. Currently, no FDA-approved vaccines or therapeutics are available to treat VEEV exposure and resultant disease manifestations. The C-terminus of the VEEV
Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan   +5 more
doaj   +1 more source

Two Lineages of DS‐1‐Like G3P[8] Human Rotaviruses in Sabah, Malaysia: Genetic Diversity and Evidence of Reassortment

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Group A rotavirus (RVA) genotype G3P[8] strains typically carry a Wa‐like genomic backbone, but DS‐1‐like G3P[8] reassortants have disseminated globally since 2013. In Sabah, Malaysia, surveillance in 2018–2019 identified frequent G3P[8] strains with a short RNA electropherotype, consistent with DS‐1‐like backbones.
Yuki Akari, Lia Natasha Amit, Jecelyn Leaslie John, Daisuke Mori, Abraham Zefong Chin, Andau Konodan Mosiun, Saori Fukuda, Maurine Mumo Mutua, Ibuki Sato, Yoshimasa Maeno, Kamruddin Ahmed, Satoshi Komoto   +11 more
wiley   +1 more source

Interspecies recombination in NSP3 gene in the first porcine rotavirus H in Russia identified using nanopore-based metagenomic sequencing

Frontiers in Veterinary Science, 2023
During the last decade, porcine rotavirus H was detected in the USA, Asian regions, South Africa, Brazil, and a couple of European countries. In the presented study, the virus was identified in piglets on a farrow-to-finish farm in Russia during ...
N. Krasnikov, A. Yuzhakov
semanticscholar   +1 more source

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Cell & Bioscience, 2021
Background Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex.
Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin, Liubing Du, Yunyun Jin, Liu Cao, Jingquan Tan, Xing-Ding Zhang, Deyin Guo, Ji-An Pan, Xiaoxue Peng   +12 more
doaj   +1 more source

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

bioRxiv
A strategy for pandemic preparedness is the development of antivirals against a wide set of viral targets with complementary mechanisms of action. SARS-CoV-2 nsp3-mac1 is a viral macrodomain with ADP-ribosylhydrolase activity, which counteracts host ...
Alpha A. Lee, Isabelle Amick, J. C. Aschenbrenner, H. Barr, Jared Benjamin, Alexander Brandis, Galit Cohen, Randy Diaz-tapia, Shirly Duberstein, J. Dixon, David Cousins, Michael Fairhead, D. Fearon, James M Frick, James Gayvert, A. S. Godoy, Ed J. Griffin, Kilian V. M. Huber, L. Koekemoer, Noa Lahav, P. Marples, B. McGovern, Tevie Mehlman, Matthew C. Robinson, Usha Singh, T. Szommer, C. Tomlinson, Thomas R. Vargo, F. von Delft, Si-Yi Wang, Kris M. White, E. Williams, M. Winokan   +32 more
semanticscholar   +1 more source

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo

bioRxiv, 2023
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target. To determine the therapeutic potential
Taha Y. Taha, R. Suryawanshi, Irene P. Chen, G. Correy, P. O'Leary, Manasi P. Jogalekar, Maria McCavitt-Malvido, Morgan E. Diolaiti, Gabriella R Kimmerly, Chia-Lin Tsou, L. Martínez-Sobrido, N. Krogan, A. Ashworth, J. Fraser, M. Ott   +14 more
semanticscholar   +1 more source

Experience from an HTS campaign: Investigation of susceptibility and rescue of SARS-CoV-2 nsp3 protease assay from metal contamination

SLAS Technology
Different biochemical assays yield different rates of false positives than others either due to the nature of the enzyme, the technology associated with the bioassay, or properties of the compounds being screened.
Irene Georgiou, Sandra O’Neill, Colin Robinson, Fraser Cunningham, Sean N. O’Byrne, David Gray, Ian H. Gilbert, Duncan E. Scott   +7 more
doaj   +1 more source