Results 81 to 90 of about 14,170 (209)

New insights on the role of paired membrane structures in coronavirus replication [PDF]

, 2015
The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to the formation of membrane-bound replicative organelles inside infected cells. The proteins responsible for rearranging cellular membranes to form the organelles
Al-Mulla, Angelini, Angelini, Barajas, Belov, Benjamin W. Neuman, Bernasconi, Bestebroer, Calì, Chatterjee, Cottam, Cottam, Deng, Edwardson, Egger, Fontana, Gadlage, Gillespie, Gosert, Guix, Hagemeijer, Hagemeijer, Hagemeijer, Hawaa Al-Mulla, Hsu, Hurst, Imbert, Johnson, Kanjanahaluethai, Knoops, Knoops, Knoops, Kopek, Kopek, Krogh, Lauber, Lesemann, Lundin, Magliano, Maier, Maier, Maier, Manolaridis, Medina, Mendez, Miller, Monastyrska, Moreira, Neuman, Neuman, Neuman, Noack, Oostra, Oostra, Pan, Pedersen, Philip V’kovski, Pol, Posthuma, Prentice, Ratia, Reggiori, Richards, Richards, Roberts, Romero-Brey, Romero-Brey, Roosendaal, Rudzinska-Langwald, Saikatendu, Salonen, Sawicki, Schwartz, Schwartz, Serrano, Serrano, Sharma, Snijder, Snijder, Spann, Sparks, Stokes, Suhy, Tan, Teterina, Thuy, Ulasli, van Kasteren, Verheije, Volker Thiel, von Brunn, Welsch, Wojdyla, Wojdyla, Wood, Xu, Xu, Zhao, Zhong, Zirkel   +99 more
core   +1 more source

Whole‐Genome Characterization of Rare Artiodactyl‐Like G10P [14] and G8P [14] Rotavirus A Strains Detected in Pediatric Gastroenteritis Cases in Hokkaido Prefecture, Japan

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT Rotavirus alphagastroenteritidis (RVA) is the leading cause of acute gastroenteritis in young children worldwide, as well as in a wide range of animal species. In 2020 and 2022, we identified three unusual RVA strains in pediatric gastroenteritis patients in Hokkaido Prefecture, Japan, using next‐generation sequencing: one G10P[14] strain ...
Akira Takebayashi, Yuya Fukuda, Yoshiki Fujii, Hiroshi Nihira, Minako Kihara, Yoshimasa Kudou, Shuhei Adachi, Noritaka Shintani, Takeshi Tsugawa   +8 more
wiley   +1 more source

Persistent Replication of a Chikungunya Virus Replicon in Human Cells is Associated with Presence of Stable Cytoplasmic Granules Containing Non-structural Protein 3

, 2018
Chikungunya virus (CHIKV), a mosquito-borne human pathogen, causes a disabling disease characterized by severe joint pain that can persist for weeks, months or even years in patients. The non-structural protein 3 (nsP3) plays essential roles during acute
Curd, A, Gao, Y, Harris, M, Hughes, RE, Merits, A, Peckham, M, Remenyi, R, Zothner, C   +7 more
core   +1 more source

Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans [PDF]

, 2009
The Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is ...
Hon, CC, Lam, TTY, Leung, FCC, Li, Y, Poon, LLM, Shi, Z, Wang, D, Xu, G, Yuan, J, Zhang, H, Zhou, P   +10 more
core   +3 more sources

Enhancing the Outcome of Crystallographic Fragment Screening by Choosing the Optimal Protein Crystal Form

Small Science, Volume 6, Issue 3, March 2026.
The selection of the crystal form impacts crystallographic fragment screening (CFS) hit rates. Almost identical CFS campaigns using monoclinic versus orthorhombic crystals of SARS‐CoV‐2 main protease yield hit rates of 3% and 16%. The higher hit rate correlates with larger solvent channels and a less constrained active site in the orthorhombic form ...
Tatjana Barthel, Jan Wollenhaupt, Laila S. Benz, Patrick Reinke, Linlin Zhang, Melanie Oelker, Frank Lennartz, Helena Taberman, Uwe Mueller, Alke Meents, Rolf Hilgenfeld, Manfred S. Weiss   +11 more
wiley   +1 more source

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

mBio, 2017
Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals.
Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena   +7 more
doaj   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, Volume 7, Issue 2, February 2026.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, Volume 13, Issue 4, 19 January 2026.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

hnRNP A1 interacts with the genomic and subgenomic RNA promoters of Sindbis virus and is required for the synthesis of G and SG RNA [PDF]

, 2010
Background Sindbis virus (SV) is the prototype of alphaviruses which are a group of widely distributed human and animal pathogens. Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an RNA-binding protein that shuttles between the nucleus ...
Hongxin Gui, Chi-Wei Lu, Sandra Adams, Victor Stollar, Mei-Ling Li   +4 more
core   +2 more sources