Results 101 to 110 of about 12,322 (192)

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication

mBio, 2017
Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals.
Diede Oudshoorn, Kevin Rijs, Ronald W. A. L. Limpens, Kevin Groen, Abraham J. Koster, Eric J. Snijder, Marjolein Kikkert, Montserrat Bárcena   +7 more
doaj   +1 more source

Adapted Live SARS‐CoV‐2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5

European Journal of Immunology, Volume 56, Issue 5, May 2026.
An attenuated live vaccine (OTS‐300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination.
Jana Kochmann, Tobias Britzke, Nico Joël Halwe, Lorenz Ulrich, Angele Breithaupt, G. Tuba Barut, Nadine Ebert, Bettina Salome Trüeb, Volker Thiel, Anca Dorhoi, Martin Beer, Donata Hoffmann, Björn Corleis, Jacob Schön   +13 more
wiley   +1 more source

Computational Insights for Interactions between nsP2 and nsP3 of CHIKV and Hormones through DFT Computations and Molecular Dynamics Simulations

Chemistry and Biodiversity
The non‐structural protein (nsP2 & nsP3) of the Chikungunya virus (CHIKV) is responsible for the transmission of viral infection. The main role of non‐structural proteins are involved in the transcription process at an early stage of the infection.
A. Raman, Durgesh Kumar, K. Kumari, P. Jain, I. Bahadur, Oyirwoth P. Abedigamba, Amreeta Preetam, Prashant Singh   +7 more
semanticscholar   +1 more source

SFV nsP3, containing two FGDF repeats, binds two G3BP molecules, while USP10 binds only one.

, 2015
(A) Schematic representation of the possible binding of the two FGDF motifs in nsP3-31 (left panel) to two G3BP molecules. The right panel shows the possible binding of one G3BP molecule to one FGDF domain of USP101–40.
Tatiana Sandalova (690366), Adnane Achour (113247), Tim Schulte (690365), Nancy Kedersha (690367), Marc D. Panas (690364), Bastian Thaa (418825), Gerald M. McInerney (250016)   +6 more
core   +1 more source

Knockout TMEM41B inhibits the formation of DMVs induced by NSP3 and NSP4 from SARS-CoV-2.

, 2021
(A) Schematic illustration of the backbone of SARS-CoV-2 Nsps plasmids. First, we generated TMEM41B KO HEK293T cell lines. Subsequently, we constructed PLV-mCherry-SARS-CoV-2-NSP3 and PLV-eGFP-SARS-CoV-2-NSP4 lentiviral expression vectors.
Limeng Sun (9321756), Jinfu Zhang (709197), Jingjin Li (4172617), Xiongwei Nie (9321744), Guiqing Peng (90055), Zhelin Su (11797970), Changzhi Zhao (1647001), Yanan Fu (4422967), Yuan Zhou (179597), Shengsong Xie (582082), Yubei Tan (11797973), Shuhong Zhao (48168), Yangyang Li (554659), Zhen Fu (669777), Yixin Xiang (11797976), Fei Liu (21082)   +15 more
core   +1 more source

Viral Mechanisms and Drug Influences on Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) Pathway in Human Coronaviruses Infection: A Systematic Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie, Ruth Oyawole Sikeola, Caleb Koranteng Kwayisi‐Darkwah, Gabriel Atampugbire, Emmanuel Ayitey Tagoe, Elijah Paintsil, Kwasi Torpey, Osbourne Quaye   +7 more
wiley   +1 more source

Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region

, 2010
The functions of the alphavirus-encoded nonstructural protein nsP3 during infection are poorly understood. In contrast, nsP1, nsP2, and nsP4 have known enzymatic activities and functions.
Zusinaite, Eva, Merits, Andres, Varjak, Margus   +2 more
core   +1 more source

Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis. [PDF]

, 2012
BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments.
Roy Polly, Boyce, Mark, Roy, Polly, Celma, Cristina CP, Cristina C P Celma, Boyce Mark, Mark Boyce, Polly Roy, Celma Cristina C P   +8 more
core   +1 more source

Recent Increase in Rotavirus Gastroenteritis After Five Years of Low Activity in Hokkaido Prefecture, Japan, Associated With Equine‐Like G3P[8] and G8P[8] Strains, 2025

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Rotavirus gastroenteritis decreased substantially worldwide during the COVID‐19 pandemic, and activity remained minimal in Hokkaido Prefecture, Japan, for 5 years after 2020. Hospital‐based surveillance in Hokkaido since July 2019 identified the first resurgence of rotavirus gastroenteritis in 2025.
Yuya Fukuda, Yoshiki Fujii, Atsuo Togashi, Tomohiro Nawa, Satoshi Nakamura, Ryoma Kimura, Jun Kunizaki, Yuuki Ando, Kouhei Nishino, Toshitaka Kizawa, Dai Yamamoto, Yoshiyuki Iizuka, Yuta Sasaoka, Masayoshi Kikuchi, Kousuke Nishikawa, Kazushige Nagai, Hirofumi Asakura, Shoya Shimokawa, Hiroyuki Kabutoya, Seiji Kobayashi, Takeshi Tsugawa   +20 more
wiley   +1 more source

Old World alphavirus nsP3 forms a complex with 40S ribosomal subunits via G3BP.

, 2019
A. Indicated cell lines were infected with WT SFV at MOI 10. At 7 hpi, cell lysates were prepared, immunoprecipitated using GFP-Trap (ChromoTek) and separated by SDS–PAGE. Lysates and IPs were probed for GFP, nsP3, rpS3, rpS6, rpL4 or β-tubulin. B.
Kirsi Hellström (399912), Lifeng Liu (164546), Marc D. Panas (690364), Ola Larsson (15776), Benjamin Götte (6843608), Tero Ahola (191447), Baila Samreen (6843611), Gerald M. McInerney (250016)   +7 more
core   +1 more source