Results 121 to 130 of about 12,322 (192)

Recognition of eIF4G by Rotavirus NSP3 Reveals a Basis for mRNA Circularization

, 2008
Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP).
Laboratory Of Molecular Biophysics, Caroline M. Groft, Stephen K. Burley   +2 more
core  

Identification of Three Novel Linear B-Cell Epitopes in Non-Structural Protein 3 of Porcine Epidemic Diarrhea Virus Using Monoclonal Antibodies

Viruses
Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic swine coronavirus that causes diarrhea and high mortality in piglets, resulting in significant economic losses within the global swine industry.
Mingjun Ye, Huixin Zhu, Zhen Yang, Yanni Gao, Juan Bai, Ping Jiang, Xing Liu, Xianwei Wang   +7 more
doaj   +1 more source

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +1 more source

Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.

, 2008
International audienceRotavirus nonstructural protein NSP3 interacts specifically with the 3' end of viral mRNAs, with the eukaryotic translation initiation factor eIF4G, and with RoXaN, a cellular protein of yet-unknown function. By evicting cytoplasmic
Becker, Michelle M, Bolte, Susanne, Vitour, Damien, Harb, Maya, Poncet, Didier, Brown, Spencer C, Vende, Patrice, Arold, Stefan T, Baron, Carolina H   +8 more
core   +1 more source

Development of a theoretical model for the inhibition of nsP3 of Chikungunya virus using pyranooxazoles

, 2019
Chikungunya virus (CHIKV) causes Chikungunya fever (CHIKF) and till date no effective medicine for its cure is available in market. Different research groups find various possible interactions between small molecules and non-structural proteins, viz ...
Durgesh Kumar (7215056), Abhilash Jayaraj (7215062), Kamlesh Kumari (7215059), Prashant Singh (729773)   +3 more
core   +1 more source

Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex

, 2015
Through its interaction with the 5' translation initiation factor eIF4G, poly(A) binding protein (PABP) facilitates the translation of 5'-capped and 3'-poly(A)-tailed mRNAs.
Poncet, Didier, Sarot, Emeline, Vende, Patrice, Pyronnet, Stephane, Hilma Baron, Carolina, Charpilienne, Annie, Gratia, Matthieu, Duarte, Mariela   +7 more
core   +1 more source

Fluorescence microscopy analysis of nsP3, capsid and dsRNA distribution during infection of C2C12 cells with P247A/V248A mutant CHIKV.

, 2019
C2C12 cells were electroporated with ICRES-nsP3-ZsGreen-CHIKV-P247A/V248A RNA. (A) Cells were fixed at the indicated time points post-infection and stained with antibodies to capsid protein (Cp) (white) and dsRNA (red).
Yanni Gao (6250973), Joseph Ward (645977), Niluka Goonawardane (4782675), Andrew Tuplin (3163998), Mark Harris (33805)   +4 more
core   +1 more source

The importance of the initiation codon context in NSP3-dependent translation.

, 2016
BSRT7 cells expressing NSP3 (black bars) or no NSP3 (NSP3-KO) (wo. NSP3 white bar) were electroporated with the standard RNA and with capped R-RNA (lines 1–6) with 9- (lines 1–3,6) or 5- (lines 4,5) nt-long 5’UTRs with different AUG (bold and italicized)
Cécile Laroche (842228), Didier Poncet (371932), Mariela Duarte (842231), Hilma Carolina Baron (842227), Matthieu Gratia (842225), Stéphane Pyronnet (842230), Patrice Vende (842226), Annie Charpilienne (371930), Emeline Sarot (842229)   +8 more
core   +1 more source

Regulación de la traducción mediada por la proteína NSP3 de rotavirus

, 2018
The study of the mechanisms used by different viruses to control host cell translation and favor the expression of viral proteins has been very instructive to know fundamental cellular mechanisms that regulate translation.
Padilla Noriega, Luis, Contreras Treviño, Hugo I.   +1 more
core  

O'nyong-nyong virus adaptive mutations in non-structural protein 1 and 3 enhance RNA replication and overcome FHL1 requirement. [PDF]

Emerg Microbes Infect
Hick TAH, Cirksena K, Evander M, Gerold G.   +3 more
europepmc   +1 more source