Crystallisation protocol for SARS-CoV-2 nsp3 macrodomain in P43 v2
The COVID-19 pandemic has demonstrated the need for novel therapeutic interventions and improved pandemic preparedness strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This protocol details an optimized crystallization method for the SARS-CoV-2 nsp3 macrodomain, a potential drug target. Using sitting drop vapor diffusion,
Jasmin Aschenbrenner +4 more
openaire +1 more source
The current two-step VP7 and VP4 genotyping RT-PCR assays for rotaviruses have been linked consistently to genotyping failure in an estimated 30% of RVA positive samples worldwide.
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Crystallisation protocol for SARS-CoV-2 nsp3 macrodomain in P43 v1
The COVID-19 pandemic has demonstrated the need for novel therapeutic interventions and improved pandemic preparedness strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This protocol details an optimized crystallization method for the SARS-CoV-2 nsp3 macrodomain, a potential drug target. Using sitting drop vapor diffusion,
Jasmin Aschenbrenner +4 more
openaire +1 more source
Simultaneous expression of three G genotypes of VP7 proteins in a recombinant porcine rotavirus confers protective immunity against multiple rotavirus infections. [PDF]
J VirolCheng X +11 more
europepmc +1 more source
Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction. [PDF]
Life Sci AllianceEdich M, Gao Y, Briggs DC, Thorn A.
europepmc +1 more source
Whole-genome characterisation of G12P[6] rotavirus strains possessing two distinct genotype constellations co-circulating in Blantyre, Malawi, 2008 [PDF]
, 2017 Agbemabiese, CA +10 more
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The non-vesicular cholesterol transporter GRAMD1C is a pan-coronavirus antiviral target. [PDF]
PLoS BiolSu Z +11 more
europepmc +1 more source
Antagonism of RNA silencing in the yellow fever mosquito, <i>Aedes aegypti</i>, by the nsP2 protein of the prototype alphavirus. [PDF]
Proc Natl Acad Sci U S AGupta AK, Wiley MR, Myles KM.
europepmc +1 more source
Chikungunya virus (CHIKV) inhibitors from natural sources: a medicinal chemistry perspective [PDF]
, 2015 core +1 more source
BACKGROUNDAlthough first detected in animals, the rare rotavirus strain G10P[14] has been sporadically detected in humans in Slovenia, Thailand, United Kingdom and Australia among other countries.
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