Results 151 to 160 of about 14,750 (231)

Crystallisation protocol for SARS-CoV-2 nsp3 macrodomain in P43 v2

The COVID-19 pandemic has demonstrated the need for novel therapeutic interventions and improved pandemic preparedness strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This protocol details an optimized crystallization method for the SARS-CoV-2 nsp3 macrodomain, a potential drug target. Using sitting drop vapor diffusion,
Jasmin Aschenbrenner, Peter Marples, Charlie Tomlinson, Lizbé Koekemoer, Daren Fearon   +4 more
openaire   +1 more source

SARS-CoV-2 nsp3 C-terminal region: Conserved beyond coronavirus with potential role in DMV pore formation [PDF]

Yulia Pustovalova, Alexandra Pozhidaeva, Jeffrey C. Hoch   +2 more
openalex   +1 more source

NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation

, 2021
Francisco Domínguez, Nikita Shiliaev, Tetyana Lukash, Peter Agback, Oksana Palchevska, Joseph R. Gould, Chetan D. Meshram, Peter E. Prevelige, Todd J. Green, Tatiana Agback, Elena I. Frolova, Ilya Frolov   +11 more
openalex   +2 more sources

SARS-CoV-2 polyprotein expression and the induction of double-membrane vesicles. [PDF]

J Virol
Zhao M, Zhang Y, Liang Y, Lei F, Han Y, Yuan Z, Yi Z.   +6 more
europepmc   +1 more source

Crystallisation protocol for SARS-CoV-2 nsp3 macrodomain in P43 v1

The COVID-19 pandemic has demonstrated the need for novel therapeutic interventions and improved pandemic preparedness strategies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This protocol details an optimized crystallization method for the SARS-CoV-2 nsp3 macrodomain, a potential drug target. Using sitting drop vapor diffusion,
Jasmin Aschenbrenner, Peter Marples, Charlie Tomlinson, Lizbé Koekemoer, Daren Fearon   +4 more
openaire   +1 more source

Trans-complementation of chikungunya virus replicase mutants reveals alphavirus replication complexity and supports antiviral tool development. [PDF]

PLoS Pathog
Wang S, Naumenko K, Mirzajani Sarvandani M, Lello LS, Makhotina A, Claesson HC, Žusinaite E, Merits A.   +7 more
europepmc   +1 more source

Autoassemblage de la partie C-terminale transmembranaire de la protéine nsp3 du virus SARS-CoV-2 [PDF]

Marion Babot, Stéphane Bressanelli, Virginie Gervais   +2 more
openalex   +1 more source

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

, 2023
Stefan Gahbauer, G.J. Correy, M. Schuller, Matteo P. Ferla, Yagmur U. Doruk, Moira Rachman, Taiasean Wu, Morgan E. Diolaiti, Siyi Wang, R. Jeffrey Neitz, D. Fearon, Dmytro S. Radchenko, Yurii S. Moroz, John J. Irwin, Adam R. Renslo, Jenny C. Taylor, Jason E. Gestwicki, F. von Delft, Alan Ashworth, Ivan Ahel, Brian K. Shoichet, James S. Fraser   +21 more
openalex   +1 more source

Chikungunya in 2025: Comprehensive Insights into Virology, Diagnostics, Vaccines, and Antiviral Therapies. [PDF]

Viruses
Zheng Z, Ji H, Shan Z, Xu J, Li J, Zhang X, Zheng J, Jiang S, Zhang N.   +8 more
europepmc   +1 more source

Reprogramming of lipid metabolism by ORF3a-induced microlipophagy enhances biogenesis of SARS-CoV-2 replication organelle. [PDF]

PLoS Pathog
Li Z, Hui X, Zheng M, He Z, Huai W, Ding B, Jin M, Qin Y, Chen M.   +8 more
europepmc   +1 more source