Results 171 to 180 of about 12,322 (192)

Lineage replacement accompanying duplication and rapid fixation of an RNA element in the nsP3 gene in a species of alphavirus [PDF]

Virology, 2011
A sequence of thirty-six nucleotides in the nsP3 gene of Ross River virus (RRV), coding for the amino acid sequence HADTVSLDSTVS, was duplicated some time between 1969 and 1979 coinciding with the appearance of a new lineage of this virus and with a ...
Wilson Choi, John Aaskov, Kym Lowry
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Phenol and chromone compounds for in silico inhibition of nsP2 and nsP3 of Chikungunya virus

Pharmaceutical Science Advances
The rising concern about neglected tropical diseases imposes a global challenge, in this sense, this work brings 12 potential candidates based on chromone and phenol compounds to inhibit nsP2 and nsP3 of the Chikungunya virus (CHIKV), through molecular ...
Joan Petrus Oliveira Lima, Caio Henrique Alexandre Roberto, Matheus Nunes da Rocha, Victor Moreira de Oliveira, R. M. Freire, Ralph Santos-Oliveira, E. S. Marinho, Pedro de Lima, Pierre Basílio Almeida Fechine   +8 more
semanticscholar   +1 more source

Optimum level of NEDD4 and its interaction with nsP3 are crucial to facilitate efficient Chikungunya virus (CHIKV) infection

Journal of General Virology
Chikungunya is a febrile infection caused by the Chikungunya virus (CHIKV), an alphavirus which has emerged as a serious public health problem globally. Despite extensive research, our understanding of different host factors facilitating effective CHIKV ...
Suchanda Verma, Sanchari Chatterjee, S. S. Keshry, A. Dhal, Bijita Bhowmick, Janu Newar, Soma Chattopadhyay, Archana Ghatak   +7 more
semanticscholar   +1 more source

PACT inhibits the replication of SARS‐CoV‐2 through the blockage of GSK‐3β‐N‐nsp3 cascade

Journal of Medical Virology, 2023
The protein activator of protein kinase R (PKR) (PACT) has been shown to play a crucial role in stimulating the host antiviral response through the activation of PKR, retinoic acid‐inducible gene I, and melanoma differentiation‐associated protein 5 ...
Yingru Lin, R. Yao, Jiaxin Zhuang, Bo Wang, Liubing Du, Deyin Guo, Jia-Yu Pan, Xiao-Xue Peng   +7 more
semanticscholar   +1 more source

Allosteric Inhibitors of the SARS-COV-2 Papain-like Protease Domain Induce Proteasomal Degradation of Its Parent Protein NSP3.

ACS Chemical Biology, 2023
The papain-like protease of SARS-COV-2 is essential for viral replication and pathogenesis. Its location within a much larger multifunctional protein, NSP3, makes it an ideal candidate for a targeted degradation approach capable of eliminating multiple ...
Peter E Cockram, Benjamin T. Walters, Aaron Lictao, Frances Shanahan, I. Wertz, S. Foster, Joachim Rudolph   +6 more
semanticscholar   +1 more source

Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules.

International Journal of Biological Macromolecules
Stress granules (SGs) are cytoplasmic aggregates of proteins and mRNA that form in response to diverse environmental stressors, including viral infections. Several viruses possess the ability to block the formation of stress granules by targeting the SGs
Xiaoyi Qi, Rui-Han Zhao, Xiao-Hui Yao, Qinqiu Liu, Panrao Liu, Zhen-Bang Zhu, Chang-Chun Tu, W. Gong, Xiangdong Li   +8 more
semanticscholar   +1 more source

Cellular uptake of metal oxide-based nanocomposites and targeting of chikungunya virus replication protein nsP3.

Journal of Trace Elements in Medicine and Biology, 2023
Emergence of new pathogenic viruses along with adaptive potential of RNA viruses has become a major public health concern. Therefore, it is increasingly crucial to investigate and assess the antiviral potential of nanocomposites, which is constantly ...
P. Bhatia, Vedita Anand Singh, R. Rani, M. Nath, S. Tomar   +4 more
semanticscholar   +1 more source

The CoV-Y domain of SARS-CoV-2 Nsp3 interacts with BRAP to stimulate NF-κB signaling and induce host inflammatory responses.

International Journal of Biological Macromolecules
Non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome. It consists of multiple domains that perform critical functions during the viral life cycle.
Kai Wang, X. Ni, Xinyue Deng, Jie Nan, Yue Ma-Lauer, A. von Brunn, Rui Zeng, J. Lei   +7 more
semanticscholar   +1 more source

The SARS‐unique domain (SUD) of SARS‐CoV‐2 nsp3 protein inhibits the antiviral immune responses through the NF‐κB pathway

Journal of Medical Virology
Nuclear factor κB (NF‐κB) plays a crucial role in various cellular processes, including inflammatory and immune responses. Its activation is tightly regulated by the IKK (IκB kinase) complex. Upon severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐
Siyi Xie, Zheng Song, Ran Chen, Xu Zhang, Shuangxin Wu, Jingliang Chen, Peiming Huang, Hanxin Liu, Kaixin Yu, Yixin Zhang, Si-Yi Tan, Jun Liu, Xiancai Ma, Hui Zhang, Xin He, Ting Pan   +15 more
semanticscholar   +1 more source

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

bioRxiv
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months 1,2or even years. Millions of people have been infected with CHIKV, mostly in low and middle-income countries, and the virus continues to spread into
J. C. Aschenbrenner, A. S. de Godoy, Michael Fairhead, C. Tomlinson, M. Winokan, Blake H. Balcomb, E. Capkin, Anu V. Chandran, M. Golding, L. Koekemoer, R. Lithgo, P. Marples, Xiao-Min Ni, W. Thompson, Conor Wild, Mary-Ann Xavier, D. Fearon, F. von Delft   +17 more
semanticscholar   +1 more source