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A Method to Monitor Activity of SARS-CoV-2 Nsp3 from Cells
2022SARS-CoV-2 protease Nsp3 is a therapeutic target for developing anti-SARS-CoV-2 drugs. Nsp3 is a large multi-spanning membrane protein, and its characterization in vitro has been challenging. Here we describe an in vitro assay to characterize the biochemical activity of full-length Nsp3 isolated from cells.
Christopher, Rainville +2 more
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Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus [PDF]
Journal of Molecular Modeling, 2014 The recent emergence and re-emergence of alphaviruses, in particular the chikungunya virus (CHIKV), in numerous countries has invoked a worldwide threat to human health, while simultaneously generating an economic burden on affected countries. There are currently no vaccines or effective drugs available for the treatment of the CHIKV, and with few lead
Paul A Keller, Hai-Bo Yu
exaly +4 more sources
Function and structure of rotavirus NSP3
2008International ...
Becker, Mm +6 more
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Getah virus Nsp3 binds G3BP to block formation of bona fide stress granules
International Journal of Biological MacromoleculesStress granules (SGs) are cytoplasmic aggregates of proteins and mRNA that form in response to diverse environmental stressors, including viral infections. Several viruses possess the ability to block the formation of stress granules by targeting the SGs marker protein G3BP.
Xiaoyi, Qi +8 more
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[Construction and expression of virus-like particles containing rotavirus NSP3 gene].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2014To construct and express ribonuclease-resistant virus-like particles containing rotavirus NSP3 gene by changing the affinity of MS2 bacteriophage coat protein pac site and to discuss the stability.In the study, 1 049 bp rotavirus NSP3 gene fragments were amplified by PCR using the primers containing PvuI and KpnI restriction enzyme sites and the ...
Le, Chang +5 more
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