Results 181 to 190 of about 14,170 (209)

A conserved motif within the NSP2 of SARS-CoV-2 is required for processing of the distal NSP1/NSP2 junction by NSP3. [PDF]

Sci Rep
Kristensen T, Normann P, Belsham GJ.
europepmc   +1 more source

A murine coronavirus infection platform identifies proviral and proinflammatory activities of SARS-CoV-2 accessory protein 7a. [PDF]

J Virol
Hawkins GM, Qing E, Salgado J, Chan P, Campbell EM, Perlman S, Gallagher T.   +6 more
europepmc   +1 more source

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2. [PDF]

Elife
Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, Kongpracha P, Bali S, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS.   +30 more
europepmc   +1 more source

Nsp3-N interactions are critical for SARS-CoV-2 fitness and virulence

Proceedings of the National Academy of Sciences of the United States of America, 2023
SARS-CoV-2, the causative agent of COVID-19 encodes at least 16 nonstructural proteins of variably understood function. Nsp3, the largest nonstructural protein contains several domains, including a SARS-unique domain (SUD), which occurs only in Sarbecovirus .
Nicholas J Schnicker, Lok-Yin Roy Wong, David K Meyerholz   +2 more
exaly   +3 more sources

Recognition of eIF4G by Rotavirus NSP3 Reveals a Basis for mRNA Circularization [PDF]

Molecular Cell, 2002
Rotaviruses, segmented double-stranded RNA viruses, co-opt the eukaryotic translation machinery with the aid of nonstructural protein 3 (NSP3), a rotaviral functional homolog of the cellular poly(A) binding protein (PABP). NSP3 binds to viral mRNA 3' consensus sequences and circularizes mRNA via interactions with eIF4G.
Stephen K Burley
exaly   +3 more sources

Recognition of the Rotavirus mRNA 3′ Consensus by an Asymmetric NSP3 Homodimer [PDF]

Cell, 2002
Rotaviruses, the cause of life-threatening diarrhea in humans and cattle, utilize a functional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for translation of viral mRNAs. NSP3 binds to viral mRNA 3' consensus sequences and circularizes the mRNA via interactions with eIF4G.
Rahul C Deo, Stephen K Burley, Mariana Gomes de Pinho   +2 more
exaly   +3 more sources

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

Antiviral Research, 2018
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various domains, the organization of which differs between CoV genera, due to duplication or absence of ...
Jian Lei, Rolf Hilgenfeld
exaly   +3 more sources

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Structure and function of rotavirus nonstructural protein NSP3

1996
The genomes of viruses in the family Reoviridae consist of segmented double-stranded RNA. There are 10 to 12 segments depending on the genus. The 5' ends and the 3' ends of the RNAs present conserved motifs for each virus genus. These conserved motifs have been hypothesized to play a role in genomic segment assortment during virus morphogenesis.
Poncet, Didier, Aponte, C., Cohen, J.
openaire   +3 more sources

Phosphorylation of sindbis virus nsP3 in vivo and in vitro

Virology, 1990
nsP3 is one of four viral nonstructural proteins required for RNA replication of Sindbis virus. In this report, post-translational modifications of nsP3 which occur in both vertebrate and mosquito cell cultures have been examined. In pulse-chase experiments, analyzed by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis ...
Li, Guangpu, La Starza, Mark W., Hardy, W. Reef, Strauss, James H., Rice, Charles M.   +4 more
openaire   +3 more sources