Results 171 to 180 of about 5,845 (181)

Phosphorylation enables allosteric control of a viral condensate

Acker J, Wang X, Desirò D, Agarwal T, Colyer A, Haller C, Scrutton R, Sherry L, Saar KL, Murray R, Fominykh K, Chong SH, Schmit JD, Calabrese AN, Knowles TPJ, Borodavka A.   +15 more
europepmc   +1 more source

PRRSV subverts host programmed cell death network for immune evasion. [PDF]

Virulence
Ma S, Mao Q, Weng S, Lian K, Jiang Z, Hao J, Zhang K.   +6 more
europepmc   +1 more source

Rotavirus NSP5-NSP2 Interaction: biological consequences

, 2001
openaire   +1 more source

Structural Organisation of the Rotavirus Nonstructural Protein NSP5

Journal of Molecular Biology, 2011
Rotavirus is one of the leading agents of gastroenteritis worldwide. During infection, viral factories (viroplasms) are formed. The rotavirus nonstructural proteins NSP5 and NSP2 are the major building blocks of viroplasms; however, NSP5 function and organisation remain elusive. In this report, we present a structural characterisation of NSP5.
Julie Menétrey, Didier Poncet
exaly   +6 more sources

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Expression and Purification of Rotavirus Proteins NSP5 and NSP6 in Escherichia coli

Cell Biochemistry and Biophysics, 2006
Rotaviruses are one of the worldwide leading causes of gastroenteritis in children under 5 yr old. The rotavirus nonstructural NSP5 is a phosphoprotein implicated in viroplasms formation, whereas NSP6 could have a possible regulatory role of NSP5. It has been reported that N- and C-termini of NSP5 are important for their function.
Antonio De Leon-Rodriguez, Ana P Barba De La Rosa   +1 more
exaly   +3 more sources

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

Antiviral Research, 2022
International audienceEffective drugs against SARS-CoV-2 are urgently needed to treat severe cases of infection and for prophylactic use. The main viral protease (nsp5 or 3CLpro) represents an attractive and possibly broad-spectrum target for drug ...
Emna Harigua-Souiai, S Paisant, A O'Brien   +2 more
exaly   +2 more sources

Porcine rotavirus C strains carrying human‐like NSP4 and NSP5

Zoonoses and Public Health, 2020
AbstractBackgroundRotavirus C (RVC) is an enteric pathogen that affects humans and animals around the world.MethodsIn this study, we characterized the genetic diversity of RVC strains detected in asymptomatic Brazilian pigs by sequencing the NSP4, NSP5 and VP6 genes.ResultsThe results of reverse transcription polymerase chain reaction showed that 53 of
Fábio Burack Costa, Patrícia Soares Flores, Ariane Ribeiro Amorim, Gabriella da Silva Mendes, Norma Santos   +4 more
openaire   +2 more sources

The Role of nsp5 in SARS-CoV-2

Theoretical and Natural Science
SARS-CoV-2, the causative agent of the COVID-19 pandemic, is a single-stranded positive-sense RNA virus belonging to the coronavirus family. It emerged at the end of 2019 and has swiftly disseminated globally, presenting an unparalleled threat to public health worldwide.
openaire   +1 more source

Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19

Journal of General Virology, 2021
Nathan A Junod, Dia C Beachboard, Christopher C Stobart   +2 more
exaly  

SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and Interferon Antagonism than Its SARS-CoV Ortholog

Journal of Virology, 2022
Jiyao Chen, Shangen Xu, Dang Wang
exaly