Results 181 to 190 of about 7,665 (202)
Estudio sobre las asociaciones intermoleculares de la proteina NSP5 de los rotavirus
, 2000 openaire +1 more source
Porcine Deltacoronavirus nsp5 Cleaves DCP1A To Decrease Its Antiviral Activity [PDF]
Journal of Virology, 2020 Interferon (IFN)-stimulated gene (ISG) induction through IFN signaling is important to create an antiviral state and usually directly inhibits virus infection. The present study first demonstrated that PDCoV nsp5 can cleave mRNA-decapping enzyme 1a (DCP1A) to attenuate its antiviral activity.
Xinyu Zhu, Yanrong Zhou, Dang Wang
exaly +3 more sources
Conserved Rotavirus NSP5 and VP2 Domains Interact and Affect Viroplasm
Journal of Virology, 2020 Alternative treatments to combat rotavirus infection are a requirement for susceptible communities where vaccines cannot be applied. This demand is urgent for newborn infants, immunocompromised patients, adults traveling to high-risk regions, and even for the livestock industry.
Kurt Tobler +2 more
exaly +4 more sources
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Structural Organisation of the Rotavirus Nonstructural Protein NSP5
Journal of Molecular Biology, 2011Rotavirus is one of the leading agents of gastroenteritis worldwide. During infection, viral factories (viroplasms) are formed. The rotavirus nonstructural proteins NSP5 and NSP2 are the major building blocks of viroplasms; however, NSP5 function and organisation remain elusive. In this report, we present a structural characterisation of NSP5.
Davy Martin +2 more
exaly +5 more sources
An ATPase activity associated with the rotavirus phosphoprotein NSP5
Virology, 2007 Interactions between NSP5 and NSP2 drive the formation of viroplasms, sites of genome replication and packaging in rotavirus-infected cells. The serine-threonine-rich NSP5 transitions between hypo- and hyper-phosphorylated isomers during the replication cycle. In this study, we determined that purified recombinant NSP5 has a Mg2+-dependent ATP-specific
Tamara Bar-Magen, Eugenio Spencer
exaly +3 more sources
Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2 [PDF]
Journal of Virology, 2017 ABSTRACT Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The first outbreak of PDCoV was announced from the United States in 2014, followed by reports in Asia. The nonstructural protein nsp5 is a 3C-like protease of coronavirus, and our previous study showed that PDCoV nsp5 inhibits type I interferon (IFN ...
Xinyu Zhu, Dang Wang, Guiqing Peng
exaly +3 more sources
Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO
Virology, 2017 Porcine deltacoronavirus (PDCoV) causes acute enteric disease and mortality in seronegative neonatal piglets. Previously we have demonstrated that PDCoV infection suppresses the production of interferon-beta (IFN-β), while the detailed mechanisms are poorly understood.
Xinyu Zhu, Liurong Fang, Dang Wang
exaly +3 more sources
Porcine rotavirus C strains carrying human‐like NSP4 and NSP5
Zoonoses and Public Health, 2020AbstractBackgroundRotavirus C (RVC) is an enteric pathogen that affects humans and animals around the world.MethodsIn this study, we characterized the genetic diversity of RVC strains detected in asymptomatic Brazilian pigs by sequencing the NSP4, NSP5 and VP6 genes.ResultsThe results of reverse transcription polymerase chain reaction showed that 53 of
Fábio Burack Costa +4 more
openaire +2 more sources
Rotavirus NSP5: Mapping Phosphorylation Sites and Kinase Activation and Viroplasm Localization Domains [PDF]
Journal of Virology, 2002 ABSTRACT Rotavirus NSP5 is a nonstructural protein that localizes in cytoplasmic viroplasms of infected cells. NSP5 interacts with NSP2 and undergoes a complex posttranslational hyperphosphorylation, generating species with reduced polyacrylamide gel electrophoresis mobility.
Catherine Eichwald +2 more
exaly +3 more sources