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Is neurotrophin-3 (NT-3): a potential therapeutic target for depression and anxiety?
Expert opinion on therapeutic targets, 2020Introduction: Neurotrophin-3 (NT-3) is thought to play a role in the neurobiological processes implicated in mood and anxiety disorders. NT-3 is a potential pharmacological target for mood disorders because of its effects on monoamine neurotransmitters ...
A. S. Miranda, J. L. Barros, A. Teixeira
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Antidiabetic Effect of a New Original NT-3 Dipeptide Mimetic
Doklady Biochemistry and Biophysics, 2023It was previously established that the original dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-monosuccinyl-L-asparaginyl-L-asparagine) (GTS-301), has a pronounced neuroprotective effect in vitro at concentrations of 10–5–10–12 М.
S S, Yagubova +4 more
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Signal and Data Authentication Experiments on NTS-3
ION GNSS+, The International Technical Meeting of the Satellite Division of The Institute of Navigation, 2021The need for GNSS (Global Navigation Satellite System) signal and data authentication for civilian users and infrastructure has been well-documented, and various methods have been investigated for two decades, notably the work of Scott. This need has recently been stressed in Space Policy Directive 7, which points towards implementation of ...
Joanna Hinks +6 more
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Gene sequences of chicken BDNF and NT-3
DNA Sequence, 1992The respective amino acid sequences of mature brain-derived neurotrophic factor (BDNF) and of mature neurotrophin-3 (NT-3) are identical among mammals, making these among the structurally conserved factors known. Here we show that only a single conservative amino acid substitution distinguishes the chicken mature NT-3 protein from its mammalian ...
P C, Maisonpierre +3 more
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Early BDNF, NT-3, and NT-4 Signaling Events
Experimental Neurology, 1999Much more is known about nerve growth factor (NGF) signaling than that initiated by brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or NT-4. We sought to study early BDNF, NT-3, and NT-4 signaling events. Using TrkB-expressing cells, we found that BDNF and NT-4 individually induced tyrosine phosphorylation of TrkB in a dose-dependent ...
E C, Yuen, W C, Mobley
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Two Promoters Direct Transcription of the Mouse NT‐3 Gene
European Journal of Neuroscience, 1994AbstractThe structure of the mouse neurotrophin‐3 (NT‐3) gene has been analysed using genomic cloning and the rapid amplification of cDNA ends (RACE) method. The gene consists of two small upstream exons (exons IA and IB) and a larger downstream exon (exon II) that encodes the mature protein. Two classes of NT‐3 transcripts, termed transcripts A and B,
A, Leingärtner, D, Lindholm
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Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity
Biochemical and Biophysical Research Communications, 2004Brn-3c is a transcription factor necessary for maturation and survival of hair cells in the inner ear. Mutations in Brn-3c are associated with deafness in mice and with hearing loss in humans. Mice lacking Brn-3c also show reduced innervation and loss of sensory neurons presumed to be an indirect effect of hair cell loss potentially through lower BDNF ...
R Lee, Clough +6 more
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Regulatory role of monoamine neurotransmitters in astrocytic NT‐3 synthesis
International Journal of Developmental Neuroscience, 2009AbstractAstrocytes actively control neuronal activity and synaptic transmission and by producing various neurotrophic factors represent an important local cellular source of trophic support in the normal and diseased brain. Our present study showed the ability of astrocytes to synthesize neurotrophin‐3 (NT‐3) and the active involvement of the monoamine
Tina, Mele +2 more
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NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival
Neuron, 1993Although proliferation is fundamental to the generation of neuronal populations, little is known about the function of trophic mechanisms during neurogenesis. We now describe a novel role for neurotrophin-3 (NT-3): the neurotrophin stimulates proliferation of sympathetic neuroblasts through trophic mechanisms.
E, DiCicco-Bloom +2 more
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NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults
Brain Research, 1994Neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) were recently shown to have biological activity in central neurons. In the present study, NT-3 and BDNF attenuated glucose deprivation-induced neuronal damage dose-dependently in rat hippocampal, septal and cortical cultures.
B, Cheng, M P, Mattson
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