Results 181 to 190 of about 16,210 (241)

NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization

Journal of Virology, 2021
Hepatitis B virus (HBV) infection is mediated by a specific interaction with sodium taurocholate-cotransporting polypeptide (NTCP), a viral entry receptor. Although the virus-receptor interactions are believed to trigger viral internalization into host cells, the exact molecular mechanisms of HBV internalization are not understood.
Kento Fukano, Mizuki Oshima, Senko Tsukuda   +2 more
exaly   +4 more sources

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Clinical effects of NTCP‐inhibitor myrcludex B

Journal of Viral Hepatitis, 2021
AbstractWith extensive research on the pathogenesis and treatment of hepatitis B virus (HBV) and hepatitis D virus (HDV) infections, the current treatment of interferon and nucleoside or nucleotide analogues provides reasonable control of viral replication in chronic hepatitis B (CHB).
Dongliang Cheng, Bing Han, Wei Zhang, Wei Wu   +3 more
openaire   +3 more sources

Structure of the bile acid transporter and HBV receptor NTCP

Nature, 2022
Chronic infection with hepatitis B virus (HBV) affects more than 290 million people worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an estimated 820,000 deaths annually1,2. For HBV infection to be established, a molecular interaction is required between the large glycoproteins of the virus envelope (known as LHBs ...
Jinta Asami, Kanako Terakado Kimura, Yoko Fujita-Fujiharu, Hanako Ishida, Zhikuan Zhang, Yayoi Nomura, Kehong Liu, Tomoko Uemura, Yumi Sato, Masatsugu Ono, Masaki Yamamoto, Takeshi Noda, Hideki Shigematsu, David Drew, So Iwata, Toshiyuki Shimizu, Norimichi Nomura, Umeharu Ohto   +17 more
openaire   +3 more sources

NTCP opens the door for hepatitis B virus infection

Antiviral Research, 2015
A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a ...
Huan Yan, Jianhua Sui, Wenhui Li
exaly   +3 more sources

Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics.

Biochemical Pharmacology, 2023
Hepatitis B is an infectious disease caused by the HBV virus. It presents a significant challenge for treatment due to its chronic nature and the potential for developing severe complications, including hepatocirrhosis and hepatocellular carcinoma. These
Zhentao Zhang, Qi Zhang, Yiwen Zhang, Yutao Lou, Luqi Ge, Wanli Zhang, Wen Zhang, Feifeng Song, Ping Huang   +8 more
semanticscholar   +1 more source

Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell

Biochimica Et Biophysica Acta - General Subjects, 2022
BACKGROUND Sodium taurocholate co-transportering polypeptide (NTCP, SLC10A1) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus.
Lushan Yu, Su Zeng
exaly   +2 more sources