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Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology [PDF]
International Journal of Molecular Sciences, 2023 The sodium-dependent organic anion transporter (SOAT, gene symbol SLC10A6) specifically transports 3′- and 17′-monosulfated steroid hormones, such as estrone sulfate and dehydroepiandrosterone sulfate, into specific target cells. These biologically inactive sulfo-conjugated steroids occur in high concentrations in the blood circulation and serve as ...
Emre Karakus +2 more
exaly +4 more sources
Cloning and Functional Characterization of Human Sodium-dependent Organic Anion Transporter (SLC10A6) [PDF]
Journal of Biological Chemistry, 2007 We have cloned human sodium-dependent organic anion transporter (SOAT) cDNA, which consists of 1502 bp and encodes a 377-amino acid protein. SOAT shows 42% sequence identity to the ileal apical sodium-dependent bile acid transporter ASBT and 33% sequence identity to the hepatic Na(+)/taurocholate-cotransporting polypeptide NTCP.
Joachim Geyer +2 more
exaly +3 more sources
Altered Bile Acid Transport in Liver Disease [PDF]
BiomedicinesBackground/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones.
Sarah Cayton, Lindsay C. Czuba
doaj +2 more sources
Journal of Steroid Biochemistry and Molecular Biology, 2018 The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis. SOAT can transport biologically inactive sulfated steroids into specific target cells, where they can be reactivated by the steroid sulfatase ...
Alberto Sánchez-Guijo +2 more
exaly +5 more sources
Molecular and Cellular Endocrinology, 2016 The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. The present study aimed to identify novel specific SOAT inhibitors for further in vitro and in vivo studies on SOAT function.
Gary Grosser +2 more
exaly +3 more sources
Pharmaceuticals, 2021 MT921 is a new injectable drug developed by Medytox Inc. to reduce submental fat. Cholic acid is the active pharmaceutical ingredient, a primary bile acid biosynthesized from cholesterol, endogenously produced by liver in humans and other mammals ...
Hyo-jeong Ryu +7 more
doaj +1 more source
JCI Insight, 2023 The pronounced choleretic properties of 24-norUrsodeoxycholic acid (norUDCA) to induce bicarbonate-rich bile secretion have been attributed to its ability to undergo cholehepatic shunting.
Jennifer K. Truong +10 more
doaj +1 more source
Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6) [PDF]
Frontiers in Pharmacology, 2018 Estrogens play a pivotal role in the development and proliferation of hormone-dependent breast cancer. Apart from free estrogens, which can directly activate the estrogen receptor of tumor cells, sulfo-conjugated steroids that maintain high plasma concentrations even after menopause first have to be imported into tumor cells by carrier-mediated uptake ...
Karakus, Emre +8 more
openaire +5 more sources
Journal of Lipid Research, 2009 In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and ...
Paul A. Dawson, Tian Lan, Anuradha Rao
doaj +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: To develop a suitable hepatocyte-like cell model that could be a substitute for primary hepatocytes with essential transporter expression and functions.
Zhi-Tao Wu +6 more
doaj +1 more source