Results 41 to 50 of about 13,748 (197)
Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors
Oncotarget, 2018 Merestinib is an oral multi-kinase inhibitor targeting a limited number of oncokinases including MET, AXL, RON and MKNK1/2. Here, we report that merestinib inhibits neurotrophic receptor tyrosine kinases NTRK1/2/3 which are oncogenic drivers in tumors bearing NTRK fusion resulting from chromosomal rearrangements.Konicek, Bruce W., Capen, Andrew R., Credille, Kelly M., Ebert, Philip J., Falcon, Beverly L., Heady, Gary L., Patel, Bharvin K.R., Peek, Victoria L., Stephens, Jennifer R., Stewart, Julie A., Stout, Stephanie L., Timm, David E., Um, Suzane L., Willard, Melinda D., Wulur, Isabella H., Zeng, Yi, Wang, Yong, Walgren, Richard A., Betty Yan, Sau-Chi +18 moreopenaire +3 more sourcesStealth multiboson signals
, 2017 We introduce the `stealth bosons' $S$, light boosted particles with a decay
$S \to AA \to q \bar q q \bar q$ into two daughter bosons $A$, which
subsequently decay into four quarks that are reconstructed as a single fat jet.Aguilar-Saavedra, J. A.core +1 more sourceProbing the "$\mu$ from $\nu$" supersymmetric standard model with
displaced multileptons from the decay of a Higgs boson at the LHC [PDF]
, 2013 The "$\mu$ from $\nu$" supersymmetric standard model ($\mu\nu$SSM) cures the
$\mu$-problem and concurrently reproduces measured neutrino data by using a set
of usual right-handed neutrino superfields. Recently, the LHC has revealed the
first scalar boson de Austri, Roberto Ruiz, Ghosh, Pradipta, Lopez-Fogliani, Daniel E., Mitsou, Vasiliki A., Munoz, Carlos +4 morecore +5 more sourcesMolecular and clinicopathologic features of gliomas harboring NTRK fusions
Acta Neuropathologica Communications, 2020 Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in ≤2% of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK inhibitors, which are among the first Food and Drug Administration-approved ...Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Anne-Florence Blandin, Melanie Pages, Azra H. Ligon, Fei Dong, David M. Meredith, MacLean P. Nasrallah, Craig Horbinski, Sonika Dahiya, Keith L. Ligon, Mariarita Santi, Shakti H. Ramkissoon, Mariella G. Filbin, Matija Snuderl, Sanda Alexandrescu +18 moredoaj +1 more sourceCollectivity in small systems - Initial state vs. final state effects [PDF]
, 2017 Observations of long rang azimuthal correlations in small collision systems
(p+p/A) have triggered an enormous excitement in the heavy-ion community.Greif, Moritz, Greiner, Carsten, Schenke, Björn, Schlichting, Sören, Xu, Zhe +4 morecore +2 more sourcesNTRK fusions in osteosarcoma are rare and non‐functional events
The Journal of Pathology: Clinical Research, 2020 Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation Baptiste Ameline, Karim H Saba, Michal Kovac, Linda Magnusson, Olaf Witt, Stefan Bielack, Michaela Nathrath, Karolin H Nord, Daniel Baumhoer +8 moredoaj +1 more sourceNTRK rearranged sarcoma of the bone. Role for larotrectinib in the neoadjuvant setting of an ultra-rare tumor: a case report
Frontiers in Oncology, 2023 Background: Neurotrophic tyrosine receptor kinase (NTRK) gene-fusion targeted molecules revolutionized the paradigm of treatment of a limited subgroup of cancers of various histologies.Emanuela Palmerini, Giorgio Frega, Marco Gambarotti, Tommaso Frisoni, Marilena Cesari, Alberto Bazzocchi, Marco Miceli, Davide Maria Donati, Davide Maria Donati, Stefano Fanti, Cristina Nanni, Stefania Benini, Alessandra Longhi, Anna Paioli, Andrea Marrari, Rossella Hakim, Alberto Righi, Toni Ibrahim +17 moredoaj +1 more sourceJet Production via Strongly-Interacting Color-Singlet Exchange in
$p\bar{p}$ Collisions
, 1995 A study of the particle multiplicity between jets with large rapidity
separation has been performed using the D{\O}detector at the Fermilab Tevatron
$p\bar{p}$ Collider operating at $\sqrt{s}=1.8$ TeV.A. A. Mayorov, A. A. Volkov, A. Baden, A. Bischoff, A. Boehnlein, A. Brandt, A. Brandt, A. Brandt, A. Bross, A. Goldschmidt, A. Jonckheere, A. K. A. Maciel, A. Kernan, A. Klatchko, A. L. Lyon, A. L. Read, A. L. Spadafora, A. Leflat, A. Milder, A. Mincer, A. N. Galyaev, A. Narayanan, A. P. Heinson, A. P. Vorobiev, A. Para, A. Peryshkin, A. Pluquet, A. R. Clark, A. S. Ito, A. Santoro, A. Smith, A. Sznajder, A. Taketani, A. V. Kostritskiy, A. V. Kozelov, A. White, A. Zieminski, A. Zylberstejn, B. Abbott, B. Baldin, B. C. Choudhary, B. G. Pope, B. Gibbard, B. Gobbi, B. Gómez, B. Hoeneisen, B. I. Klochkov, B. Klima, B. Mansoulié, B. May, B. S. Acharya, C. Boswell, C. Cretsinger, C. E. Gerber, C. H. Park, C. K. Jung, C. Klopfenstein, C. L. Kim, C. Murphy, C. S. Mishra, C. Shaffer, C. T. Murphy, C. Yanagisawa, C. Yoshikawa, D. A. Stoianova, D. Buchholz, D. Casey, D. Chakraborty, D. Claes, D. Cullen-Vidal, D. Cutts, D. Denisov, D. Edmunds, D. Fein, D. H. Zhang, D. Hedin, D. Koltick, D. L. Adams, D. Lincoln, D. Nešić, D. Norman, D. Owen, D. Pušeljić, D. R. Green, D. R. Wood, D. Stewart, D. Stoker, D. Vititoe, D. Zieminska, E. A. Kozlovski, E. Amidi, E. Flattum, E. Gallas, E. Gotsman, E. James, E. Neis, E. Oltman, E. Shabalina, E. W. Anderson, E. W. Varnes, E. Won, F. Abe, F. Borcherding, F. Hsieh, F. Lobkowicz, F. Nang, F. Wen, G. A. Alves, G. Blazey, G. Di Loreto, G. E. Forden, G. Eppley, G. Finocchiaro, G. Griffin, G. Guglielmo, G. Kalbfleisch, G. Landsberg, G. Marchesini, G. R. Snow, G. Wang, G. Álvarez, H. A. Neal, H. Aihara, H. B. Prosper, H. C. Shankar, H. Castilla-Valdez, H. D. Wahl, H. E. Fisk, H. E. Montgomery, H. Gordon, H. Greenlee, H. Haggerty, H. Johari, H. Johnstad, H. Jöstlein, H. L. Melanson, H. Li, H. Miettinen, H. N. Chehime, H. Piekarz, H. S. Mao, H. Schellman, H. T. Diehl, H. Weerts, H. Xu, H.-U. Bengtsson, I. Adam, I. Bertram, I. V. Mandrichenko, J-F. Lebrat, J. A. Guida, J. A. Wightman, J. Alitti, J. B. Singh, J. Balderston, J. Bantly, J. Bendich, J. Borders, J. Cochran, J. D. Bjorken, J. D. Hobbs, J. Drinkard, J. Ellison, J. F. Bartlett, J. Featherly, J. G. R. Lima, J. Green, J. H. Christenson, J. Jaques, J. Kotcher, J. Kourlas, J. L. González Solís, J. Li, J. Linnemann, J. M. Butler, J. M. de Miranda, J. M. Guida, J. M. Hauptman, J. M. Kohli, J. McKinley, J. P. Negret, J. Perkins, J. Pumplin, J. Qian, J. R. T. de Mello Neto, J. Rutherfoord, J. S. Hoftun, J. S. Kang, J. Sculli, J. Solomon, J. T. White, J. Tarazi, J. Teiger, J. Thompson, J. V. D. Wirjawan, J. Warchol, J. Wilcox, J. Womersley, J. Yang, J. Yu, J. Z.-Y. Jiang, K. Bazizi, K. C. Frame, K. De, K. Denisenko, K. Genser, K. Johns, K. S. Hahn, K. Streets, K. W. Merritt, L. Chevalier, L. Kerth, L. Lueking, L. Markosky, L. Oesch, L. Rasmussen, L. Sawyer, L. T. Goss, L.-P. Chen, M. A. C. Cummings, M. Abolins, M. Adams, M. Bhattacharjee, M. Chung, M. Demarteau, M. Derrick, M. Diesburg, M. Fatyga, M. Fortner, M. Goforth, M. I. Martin, M. Johnson, M. Jones, M. K. Fatyga, M. L. Kelly, M. L. Stevenson, M. Marx, M. Mohammadi-Baarmand, M. Mudan, M. Narain, M. Nicola, M. Pang, M. Paterno, M. Peters, M. R. Krishnaswamy, M. Rijssenbeek, M. Shupe, M. Sosebee, M. Souza, M. Strovink, M. Tartaglia, M. V. S. Rao, M. Wayne, N. A. Roe, N. Amos, N. Biswas, N. Denisenko, N. Graf, N. Grossman, N. I. Bojko, N. J. Hadley, N. K. Mondal, N. Mokhov, N. Oshima, N. Parua, N. Varelas, O. I. Dahl, O. Ramirez, O. V. Eroshin, P. A. Rapidis, P. Bloom, P. C. Bhat, P. D. Grannis, P. Draper, P. Ermolov, P. Franzini, P. Grudberg, P. Gutierrez, P. I. Goncharov, P. M. Sood, P. M. Tuts, P. Mooney, P. Nemethy, P. Padley, P. R. G. Virador, P. Rubinov, P. Tamburello, P. Yamin, P. Z. Quintas, Ph. Mangeot, Q. Z. Li-Demarteau, Q. Zhu, R. Astur, R. Brock, R. D. Schamberger, R. Demina, R. Dixon, R. E. Avery, R. E. Hall, R. Engelmann, R. Hatcher, R. Hernández-Montoya, R. Hirosky, R. J. Genik II, R. J. Madaras, R. K. Shivpuri, R. Kehoe, R. Lipton, R. Madden, R. Markeloff, R. McCarthy, R. P. Smith, R. Partridge, R. Raja, R. Ruchti, R. S. Fletcher, R. Snihur, R. W. Stephens, R. Yamada, S. A. Jerger, S. Abachi, S. Abachi, S. Abachi, S. Ahn, S. B. Beri, S. Blessing, S. C. Loken, S. Chopra, S. Durston-Johnson, S. Eno, S. Fahey, S. Feher, S. Fuess, S. Glenn, S. Grünendahl, S. H. Aronson, S. Hagopian, S. Hansen, S. Igarashi, S. J. Wimpenny, S. K. Kim, S. Kahn, S. Krzywdzinski, S. Kunori, S. L. Linn, S. Lami, S. Lökös, S. Mani, S. Margulies, S. N. Gurzhiev, S. P. Denisov, S. Protopopescu, S. R. Dugad, S. Rajagopalan, S. Reucroft, S. Rusin, S. Snyder, S. V. Chekulaev, S. Willis, S. Y. Jun, S. Youssef, S.-M. Chang, T. Ahmed, T. Fahland, T. Ferbel, T. G. Trippe, T. Heuring, T. Huehn, T. Joffe-Minor, T. L. Geld, T. L. Taylor, T. Marshall, T. McKibben, T. McMahon, T. Rockwell, T. Yasuda, Tao Hu, Ting Hu, Tong Hu, U. Heintz, V. A. Bezzubov, V. Balamurali, V. Bhatnagar, V. D. Elvira, V. Del Duca, V. Glebov, V. Hagopian, V. I. Klyukhin, V. I. Kochetkov, V. M. Podstavkov, V. N. Evdokimov, V. Oguri, V. S. Burtovoi, V. S. Narasimham, V. Sirotenko, W. Carvalho, W. Chen, W. E. Cooper, W. G. Cobau, W. Guryn, W. Smart, W. X. Gu, Y. C. Liu, Y. Ducros, Y. E. Gutnikov, Y. Fisyak, Y. K. Li, Y. M. Park, Y. Pischalnikov, Y. Y. Shao, Y. Yu, Yu. L. Dokshitzer, Z. H. Zhu +412 morecore +1 more sourceBrain Metastases From Differentiated Thyroid Cancer in the Era of Targeted Therapies: A Multi‐Center Retrospective Cohort
Head &Neck, EarlyView.ABSTRACT Background
Brain metastases (BM) of differentiated thyroid carcinoma (DTC) are associated with unfavorable prognosis. This study evaluated BM management strategies and patients' outcomes. Methods
A retrospective review of patients diagnosed with DTC and BM at Tel Aviv Sourasky and Rabin Medical Centers between 1985 and 2024. Clinical features, Liyona Kampel, Shaun Edalati, Eyal Yosefof, Anton Warshavsky, Gilad Horowitz, Nidal Muhanna, Hagit Shoffel‐Havakuk, Eyal Robenshtok, Aron Popovtzer, Inbar Finkel +9 morewiley +1 more source
