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NTRK gene fusion testing and management in lung cancer

Cancer Treatment Reviews
Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are recurrent oncogenic drivers found in a variety of solid tumours, including lung cancer. Several tropomyosin receptor kinase (TRK) inhibitors have been developed to treat tumours with NTRK gene fusions.
Matteo Repetto
exaly   +5 more sources

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Identification of NTRK fusions in pediatric mesenchymal tumors

Pediatric Blood & Cancer, 2017
AbstractBackgroundNTRK fusions are known oncogenic drivers and have recently been effectively targeted by investigational agents in adults. We sought to assess the frequency of NTRK fusions in a large series of pediatric and adolescent patients with advanced cancers.ProcedureGenomic profiles from 2,031 advanced cancers from patients less than 21 years ...
Dean, Pavlick, Alexa B, Schrock, Denise, Malicki, Philip J, Stephens, Dennis J, Kuo, Hyunah, Ahn, Brian, Turpin, Justin M, Allen, Mark, Rosenzweig, Kamran, Badizadegan, Jeffrey S, Ross, Vincent A, Miller, Victor, Wong, Siraj M, Ali   +13 more
openaire   +2 more sources

173P Entrectinib in NTRK fusion-positive (NTRK-fp) breast cancer

2022
BackgroundFusions in the neurotrophic tyrosine receptor kinase (NTRK) genes act as oncogenic drivers in many solid tumours, including secretory and non-secretory breast cancers. In the phase 2 STARTRK-2 clinical trial (NCT02568267), entrectinib (a TRK inhibitor with CNS activity) induced objective responses in 83.3% of patients (pts) with NTRK-fp ...
Lu, J., Blakely, C.M., Barve, M., Chung, C.H., Waqar, S.N., Hu, X., Delord, J-P., Krzakowski, M.J., Yonemori, K., Chen, D.T., Klingbiel, D., Heinzmann, S., Le Tourneau, C.   +12 more
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NTRK fusions and Trk proteins: what are they and how to test for them

Human Pathology, 2021
The NTRK genes include a family of three genes, NTRK1, NTRK2, and NTRK3, which are associated with fusions with a variety of partner genes, leading to upregulation of three proteins, TrkA, TrkB, and TrkC. NTRK fusions occur in a variety of solid tumors: at high incidence in secretory carcinoma of the breast and salivary glands, congenital mesoblastic ...
Lawrence M, Weiss, Vincent A, Funari
openaire   +2 more sources

NTRK fusion genes in thyroid cancer

Endocrine Abstracts, 2021
Barbora Pekova, Vlasta Sykorova, Karolina Mastnikova, Eliska Vaclavikova, Jitka Moravcova, Vlcek Petr, Petr Lastuvka, Milos Taudy, Rami Cisel, Petr Bavor, Daniela Kodetova, Martin Kodetova, Jana Drozenova, Jaromir Kodetova, Petr Hrabal, Josef Vcelak, Bela Bendlova   +16 more
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Cost-effectiveness of NTRK testing strategies for detecting NTRK fusions in solid tumors in China.

Journal of Clinical Oncology
3131 Background: Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are oncogenic drivers in many solid tumors. With the inclusion of the targeted drug Entrectinib in China's national reimbursement drug list, the demand for NTRK testing has also increased.
Jian Wang, Lifeng Wang, Shenglei Li, Wen Chen   +3 more
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NTRK Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis

Cancers, 2021
Bela Bendlova, Rami Katra, Martin Chovanec   +2 more
exaly  

Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer

Lung Cancer, 2021
Hans Brunnström, Patrick Micke, Hedvig Elfving   +2 more
exaly  

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Frontiers in Oncology, 2023
Takumi Kawaguchi, Sachiko Nagasu
exaly   +2 more sources