Results 71 to 80 of about 3,270,734 (378)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

High-Field Dynamic Nuclear Polarization.

open access: yesAnnual review of physical chemistry (Print), 2020
Dynamic nuclear polarization (DNP) is one of the most prominent methods of sensitivity enhancement in nuclear magnetic resonance (NMR). Even though solid-state DNP under magic-angle spinning (MAS) has left the proof-of-concept phase and has become an ...
B. Corzilius
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Electrochemistry of cobalt ethylenediamine complexes at high pH [PDF]

open access: yesJournal of the Serbian Chemical Society, 2015
In this work the electrochemical behavior of cobalt ethylendiamine complexes (Co(en)), at pH 12 has been investigated by cyclic voltammetry (CV), potentiostatic pulse technique and polarization curve measurements at stationary and rotating ...
Miulović Snežana M.   +5 more
doaj   +1 more source

Classical Trajectories for two Ring-Shaped Potentials

open access: yes, 1998
This paper deals with the classical trajectories for two super-integrable systems: a system known in quantum chemistry as the Hartmann system and a system of potential use in quantum chemistry and nuclear physics.
Kibler, M.   +2 more
core   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Spin-Mediated Consciousness Theory: Possible Roles of Neural Membrane Nuclear Spin Ensembles and Paramagnetic Oxygen [PDF]

open access: yes, 2004
A novel theory of consciousness is proposed in this paper. We postulate that consciousness is intrinsically connected to quantum spin since the latter is the origin of quantum effects in both Bohm and Hestenes quantum formulism and a fundamental quantum ...
Hu, Huping, Wu, Maoxin
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Nuclear Astrophysics [PDF]

open access: yes, 1998
Nuclear astrophysics is that branch of astrophysics which helps understanding some of the many facets of the Universe through the knowledge of the microcosm of the atomic nucleus.
Arnould, M., Takahashi, K.
core   +3 more sources

Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals.

open access: yesInorganic Chemistry, 2014
Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics.
Brian M. Zeglis   +4 more
semanticscholar   +1 more source

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