Results 81 to 90 of about 332,491 (297)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Radiochemistry and nuclear chemistry workforce in the United States. [PDF]

J Appl Clin Med Phys, 2022
Tolmachev SY, Auxier JD, Nilsson M, Powell BA, Rucker TL, Sudowe R.   +5 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

An introduction to serious nuclear accident chemistry

, 2015
A review of the chemistry occurring inside a nuclear power plant during a serious reactor accident is presented. This includes some aspects of the behavior of nuclear fuel, its cladding, cesium and iodine.
Foreman, Mark,
core  

Characterization of Ku70(2)-NLS as bipartite nuclear localization sequence for non-viral gene delivery. [PDF]

, 2012
Several barriers have to be overcome in order to achieve gene expression in target cells, e.g. cellular uptake, endosomal release and translocation to the nucleus.
Maucksch, Christof, Mittal, Rashmi, Rudolph, Carsten, Rashmi Mittal, Mittal Rashmi, Christof Maucksch, Alexander Bohla, Maucksch Christof, Carsten Rudolph, Joseph Rosenecker, Bohla, Alexander, Matschke, Johannes, Rosenecker Joseph, Bohla Alexander, Matschke Johannes, Rosenecker, Joseph, Rudolph Carsten, Johannes Matschke   +17 more
core   +1 more source

Separation Chemistry for the Nuclear Industry

Analytical Sciences, 1991
A review of the actinide and lanthanide extraction chemistry by N, N-dialkylamides and N, N'- tetraalkylamides is given. It includes the extraction equilibria of inorganic acids. The prospects of using. these completely incinerable extractants in the nuclear fuels cycle is discussed.
MUSIKAS, CLAUDE, CONDAMINES, NICOLE, CUILLERDIER, CHRISTINE   +2 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Uso da espectroscopia de ressonância magnética nuclear de 1He 13C na análise de uvas e vinhos brasileiros [PDF]

, 2005
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências e Matemáticas. Programa de Pós-Graduação em QuímicaUm dos objetivos da química analítica moderna é o desenvolvimento de técnicas capazes de identificar e quantificar diferentes
Amaral, Fabiana Mortimer
core  

New methods and applications in solid-state NMR spectroscopy of quadrupolar nuclei

, 2014
The authors acknowledge the EPSRC for the award of a studentship to S.S. Accepted Oct 8th 2014Solid-state nuclear magnetic resonance (NMR) spectroscopy has long been established as offering unique atomic-scale and element-specific insight into the ...
Ashbrook, Sharon E, Sneddon, Scott
core   +1 more source